Acute neutrophilic dermatosis with diffuse histiocytic lymphoma

Sweet’s Syndrome with Myelofibrosis and Leukemia: Partial Response to Interferon

“…AND or Sweet's syndrome has been associated with myelofibrosis in a few patients, usually in association with myeloid metaplasia [2][3][4], The hematologic abnormalities in these patients may progress to frank leukemia. The resemblance of so-called atypical or bullous pyoderma gangraenosum to Sweet's syndrome [17][18][19][20] was noted in the discussion by Pegum [21J after presentation of a patient labeled as having 'bullous pyoderma gangraenosum' and chronic myeloid leukemia.…”

“…The resemblance of so-called atypical or bullous pyoderma gangraenosum to Sweet's syndrome [17][18][19][20] was noted in the discussion by Pegum [21J after presentation of a patient labeled as having 'bullous pyoderma gangraenosum' and chronic myeloid leukemia. These neutrophilic dermatoses are pail of the same spectrum, often without fever or neu trophilia, hence the unifying name AND -as the histologic pattern in these patients consistently displays an extensive diffuse dermal infiltrate of neutrophils often with leukocytoclasia 11,3], There have been over 60 patients reported with AND and myeloproliferative disease [6, 13-16, 22, 23]; the latter was usually detected months after the onset of the skin changes, although in some patients they were detected simultaneously [2,22]; a few patients with AND have been first observed after the malignant diagnosis was established. The course of the skin lesions has been noted to parallel the leukemia, with the original observation of the rapid demise of the patient occurring in most cases so far reported, usually from myelogenous leukemia [19,24], AND has also been reported in association with myeloma, T-cell lymphoma, histiocytic lymphoma and over 40 solid tumors [1, 2, 13-15, 24-27], These solid tumors include carci noma of the ovary, testes, breast, uterus, stomach, vagina, colon, prostate, rectum, kidney and thyroid [13-15, 25, 27], Extracutaneous manifestations of Sweet's syndrome are varied.…”

“…The course of the skin lesions has been noted to parallel the leukemia, with the original observation of the rapid demise of the patient occurring in most cases so far reported, usually from myelogenous leukemia [19,24], AND has also been reported in association with myeloma, T-cell lymphoma, histiocytic lymphoma and over 40 solid tumors [1, 2, 13-15, 24-27], These solid tumors include carci noma of the ovary, testes, breast, uterus, stomach, vagina, colon, prostate, rectum, kidney and thyroid [13-15, 25, 27], Extracutaneous manifestations of Sweet's syndrome are varied. Beside the fever and neutrophilia, which may or may not be present, there may be a nondeforming asymme tric large joint arthritis, coinjunctivitis, episcleritis, mesangiocapillary glomerulonephritis, hepatitis and pulmonitis [2,14,25]. The latter may be manifest as an infiltration by neutrophils within the lung parenchyma evident on a chest roentgenogram; it is culture negative [28].…”

Sweet’s Syndrome: Association with Accelerated Phase of Chronic Myeloid Leukemia

“…22 [21] 58/M NHLdiffuse histiocytic not specified cleared with corticotherapy 23 [11] 32/M MF not specified cleared with corticotherapy 24 [18] 6 6 /F MF arms, axillas, breast triamcinolone (90% healed) 25 [19] 19/F CML blast crisis not specified cleared with corticotherapy 26 [7] 4 6 /F CML blast crisis not specified cleared with corticotherapy 27 [this article] 33/F CML accelerated phase shoulders, face, neck prednisone (reduction 60%) AML = Acute myeloid leukemia; AL = acute leukemia (not specified); AProL = acute promyelocytic leukemia; AMMoL = acute myelomonocytic leukemia; RAEB = refractory anemia with excess of blasts; NHL -non-Hodgkin's lymphoma; MF = idiopathic myelofibrosis; CML = chronic myeloid leukemia. the deep underlying dermis were detected and a diagnosis of AFND was made ( fig.…”

“…However, up to now, perhaps 20 cases have been described in association with acute nonlymphocytic leukemia [2-6, 8-10, 13-18]; another 6 cases have been described in asso ciation either with refractory anemia [16], non-Hodg kin's lymphomas [20,21] or myelofibrosis [11,18]. To our knowledge only 2 cases have been reported in as sociation with chronic myeloid leukemia (CML) in blast crisis [7,19] (table 1).…”