Sweet’s Syndrome: Association with Accelerated Phase of Chronic Myeloid Leukemia

Abstract

The authors describe a case of Sweet’s syndrome in a woman affected with chronic myeloid leukemia. They emphasize the association of the syndrome with a progression of the disease and the complete disappearance of it for 3 years until the present time after allogeneic bone marrow transplantation.

Neutrophilic Pustulosis Associated with Chronic Myeloid Leukemia: A Special Form of Sweet’s Syndrome

“…Among the latter, acute myeloblastic leuke mia is the most frequently associated disease, but some pa tients with CML have also been reported [4][5][6], Indeed, in a recent review of the world literature, Cohen et al [4] col lected 6 such instances, to which 2 further cases must be added [5,6], In all subjects with CML and Sweet's syn drome, the latter disorder appeared coincidently or fol lowing diagnosis, as it occurred in our 2 patients.…”

“…The dis order typically shows a rapid response to corticosteroids and is associated in about 20% of instances with a solid tu mor or a hematologic malignancy, mainly acute myeloblastic leukemia [2]. Paraneoplastic Sweet's syndrome has also been observed in some patients with chronic myelo proliferative disorders [3], including 8 subjects suffering from chronic myeloid leukemia (CML) [4][5][6].…”

Sweet’s Syndrome during the Chronic Phase of Chronic Myeloid Leukaemia

“…Sweet's syndrome had been reported in some cases of chronic myeloid leukaemia in the accelerated phase or concomitantly with blast crisis [4]. When Sweet's syndrome was diagnosed in our patient, he was in the chronic phase of the disease, as indicated by the analysis of bone marrow and karyotype.…”

“…Only a few cases of this syndrome have been reported in association with chronic myeloid leu kaemia, occurring simultaneously with the progres sion of the leukaemia (accelerated phase or blast cri sis) [4], We report the case of a 52-year-old male, referred to us in June 1987 with a history of asthenia. Physical examination revealed splenomegaly that extended 3 cm below the costal margin.…”

Hyperfunction of neutrophils in a patient with BCR/ABL negative chronic myeloid leukemia

“…However, hyperresponsiveness of myeloid progenitor cells to G-CSF and enhanced neutrophil functions in the terminal phase, including fMLP-stimulated superoxide production and in vitro production of IL-8 might be strongly related to the pathogenesis of PAP as well as Sweet syndrome and be some clues to elucidate at least a part of BCR/ABL negative CML. 24 1998 CML (1) SS Pertusi et al 25 1996 CML (1) SS Kannan et al 26 1995 CML (1) SS Brodkin and Schwartz 27 1995 CML (1) SS Dieguez et al 28 1993 CML (1) SS Torri et al 29 1993 CML (1) SS Feliu et al 30 1992 CML (2) SS Sanchez-Yus and Palou 31 1992 CML (1) SS Gonzalez-Castro et al 32 1991 CML (1) SS Mijovic et al 33 1991 CML (1) SS Elovaara et al 34 1990 CML (1) SS Bello Lopez et al 35 1990 CML (1) SS Cohen and Kurzrock 36 1989 CML (1) SS Hatch et al 37 1989 CML (1) SS Rauh et al 38 1989 CML (1) SS Visani et al 39 1988 CML (1) SS Marcos Sanchez et al 40 1985 CML (1) SS Odeh 41 1981 CML (1) SS Chmel and Armstrong 42 1978 CML (1) SS Rodriguez-Luaces et al 43 1997 CML (1) PAP Cordonnier et al 3 1994 CML (4) PAP Ito et al 44 1994 CML (1) PAP Miyake et al 45 1992 CML (1) PAP Watanabe et al 46 1990 CML (1) PAP Magy et al 47 1985 CML (1) PAP Aymard et al 48 1984 CML (1) PAP Green et al 49 1980 CML (1) PAP Miyashita et al 50 1977 CML (1) PAP Yamamoto et al 51 1975 CML (1) PAP Nakamura et al 52 1988 Graves (1) SS CML: chronic myeloid leukemia; PAP: pulmonary alveolar proteinosis; SS: Sweet syndrome.…”