Acute Necrotizing Ulcerative Gingivitis in Children With Cancer

Ryan, Michael E.; Hopkins, Kenneth P.; Wilbur, Richard B.

doi:10.1001/archpedi.1983.02140320068015

Cited by 5 publications

(5 citation statements)

References 15 publications

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“…HCMV can prime metabolic abnormalities in macrophages and lymphocytes (36,88) and suppress antigen-specific cytotoxic T-lymphocyte functions, leading to a decrease in circulating CD4"^ cells and increase in CD8"ĉ ells, resulting in a global decrease in cell-mediated immunity (36,42,71,88). Acute necrotizing ulcerative gingivitis patients seem to experience a similar inversion in T-cell ratios (32,49,72,92,93), which is also a consistent immunological finding in protein-energy deficient children (14,27).…”

Section: Discussionmentioning

confidence: 59%

“…Bacterial invasion of gingival tissues in acute necrotizing ulcerative gingivitis is associated with the impairment of host defenses. Predisposing factors for acute necrotizing ulcerative gingivitis may include poor oral hygiene and preexisting gingivitis (25,58,80,81,84), emotional stress (17,35,79), cigarette smoking (43,46), low socioeconomic status (25,58,62,80,84), malnutrition with associated immune suppression (25,27,29,40,58), altered inflammatory response (16,27,32) and systemic diseases (26,34,72,74,92). The decrease in host resistance may stem from a disruption in cellular immune protective functions (27,92) and in alterations in cytokine profiles (32,49,54).…”

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confidence: 99%

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Human Herpesviridae in acute necrotizing ulcerative gingivitis in children in Nigeria

Contreras

Falkler

Enwonwu

et al. 1997

Oral Microbiology and Immunology

122

114

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Herpesviruses have been implicated in the pathogenesis of human periodontitis. The present study investigated whether herpesviruses are present in the lesions of acute necrotizing ulcerative gingivitis. Sixty-two Nigerian children, aged 3-14 years, were studied. Twenty-two children had acute necrotizing ulcerative gingivitis and were also malnourished, 20 exhibited no acute necrotizing ulcerative gingivitis but were malnourished and 20 were free of acute necrotizing ulcerative gingivitis and in a good nutritional state. Polymerase chain reaction methods were used to determine the presence of human cytomegalovirus (HCMV), Epstein-Barr virus type 1 and type 2 (EBV-1, EBV-2), herpes simplex virus (HSV), human herpes virus 6 (HHV-6), human papilloma virus and human immunodeficiency virus type 1 in crevicular fluid specimens collected by paper points. Of the 22 acute necrotizing ulcerative gingivitis patients, 15 (68%) revealed viral infection and 8 (36%) viral coinfection. Thirteen (59%) acute necrotizing ulcerative gingivitis patients demonstrated HCMV, 6 (27%) EBV-1, 5 (23%) HSV and 1 (5%) HHV-6. Only 2 (10%) subjects from each group not affected by acute necrotizing ulcerative gingivitis showed viral presence, and no control subject revealed viral coinfection. These findings suggest that HCMV and possibly other herpesviruses contribute to the onset and/or progression of acute necrotizing ulcerative gingivitis in malnourished Nigerian children.

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Section: Discussionmentioning

confidence: 59%

mentioning

confidence: 99%

Human Herpesviridae in acute necrotizing ulcerative gingivitis in children in Nigeria

Contreras

Falkler

Enwonwu

et al. 1997

Oral Microbiology and Immunology

122

114

View full text Add to dashboard Cite

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“…ANUG is characterized by destruction of the free margin, crest and interdental papillae with ultimate formation of a pseudomembrane [40]. The most commonly implicated pathogens are spirochetes and the anaerobic bacteria of the subgingival flora [41].…”

Section: Discussionmentioning

confidence: 99%

Acute Myelogenous Leukemia Complicated by Acute Necrotizing Ulcerative Gingivitis Due to Aspergillus terreus

Khoury¹,

Poh²,

Williams³

et al. 2003

Leukemia & Lymphoma

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Infections caused by Aspergillus terreus are rare but have been associated with a poor outcome in immunocompromised patients due to frequent resistance to conventional antifungal therapy. This report describes a case of a woman who developed acute necrotizing ulcerative gingivitis (ANUG) due to A. terreus during induction chemotherapy for acute myelogenous leukemia. She initially failed to respond to treatment with amphotericin B but the infection resolved following the introduction of oral itraconazole. Opportunistic infections caused by A. terreus are an emerging problem and can be associated with a high mortality rate. Early microbiological diagnosis is critical since resistance to amphotericin B is likely and itraconazole appears to be an effective treatment for this infection.

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“…Forest plots of odds ratio of macrodontia. Refs [ 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 , 90 , 91 , 92 ] are cited in the Supplementary Materials.…”

mentioning

confidence: 99%

Chemotherapy and Radiotherapy Long-Term Adverse Effects on Oral Health of Childhood Cancer Survivors: A Systematic Review and Meta-Analysis

Pombo Lopes,

Rodrigues,

Machado

et al. 2023

Cancers

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The survival rate for pediatric cancer has increased over the past few decades, short- and long-term complications have been detected and studied, and oral complications have emerged as an important topic of research. Here, we aimed to highlight the importance of oral manifestations that may only become apparent years or even decades after cancer treatment. This systematic review was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis. We searched articles using PubMed via the MEDLINE, Web of Science, and LILACS databases until October 2023. Overall, 35 observational studies were included, and the results estimated a pooled prevalence of the following dental anomalies: discoloration, 53%; crown-root malformations and agenesis, 36%; enamel hypoplasia, 32%; root development alterations, 29%; unerupted teeth, 24%; microdontia, 16%; hypodontia, 13%; and macrodontia, 7%. Most childhood cancer survivors have at least one dental sequela. Childhood cancer survivors presented a higher risk of having dental alterations than control counterparts. Additional analyses reveal possible sex-based differences that should be explored in future studies. These results collectively highlight the importance of oral healthcare and the prevention of disease in childhood cancer survivors.

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Acute Necrotizing Ulcerative Gingivitis in Children With Cancer

Cited by 5 publications

References 15 publications

Human Herpesviridae in acute necrotizing ulcerative gingivitis in children in Nigeria

Human Herpesviridae in acute necrotizing ulcerative gingivitis in children in Nigeria

Acute Myelogenous Leukemia Complicated by Acute Necrotizing Ulcerative Gingivitis Due to Aspergillus terreus

Chemotherapy and Radiotherapy Long-Term Adverse Effects on Oral Health of Childhood Cancer Survivors: A Systematic Review and Meta-Analysis

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