Acute myocarditis after a third dose of the BNT162b2 COVID-19 vaccine

Fosch, Xavier; Serra, J. Dalmau; Torres, P. L.; Preda, Luminita; González, Rosa María Galindo; Mojer, Francisca

doi:10.1016/j.rec.2022.01.009

Cited by 8 publications

(7 citation statements)

References 5 publications

(4 reference statements)

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“…Overall, 266 publications were retrieved for review of full‐text articles. Finally, 102 publications, including 56 case reports 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 92 , 93 , 94 , 97 , 98 , 101 , 102 , 105 , 106 an...…”

Section: Resultsmentioning

confidence: 99%

“…Overall, 266 publications were retrieved for review of full‐text articles. Finally, 102 publications, including 56 case reports 12–50,52–58,92–94,97,98,101,102,105,106 and 46 case series 5,7,10,23,35,45,51,59–91,95,96,100,103,104,107 fulfilled the inclusion criteria. Figure 1 shows the selection process in detail.…”

Section: Resultsmentioning

confidence: 99%

“…Timely diagnosis and management are crucial for improving the prognosis of this complication 5 . An increasing number of studies have utilized cardiac MRI, as the most important noninvasive diagnostic tool, to assess suspected myocarditis associated with COVID‐19 vaccination 5–105 . One narrative review article attempted to address the pattern of myocardial injury following COVID‐19 vaccination based on cardiac MRI findings from 11 case series 4 .…”

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confidence: 99%

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Cardiac MRI Findings in COVID‐19 Vaccine‐Related Myocarditis: A Pooled Analysis of 468 Patients

Samimisedeh

Afshar

Hassani

et al. 2022

Magnetic Resonance Imaging

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Understanding the pattern and severity of myocarditis caused by the coronavirus disease 2019 (COVID‐19) vaccine is imperative for improving the care of the patients, and cardiac evaluation by MRI plays a key role in this regard. Our systematic review and meta‐analysis aimed to summarize cardiac MRI findings in COVID‐19 vaccine‐related myocarditis. We performed a comprehensive systematic review of literature in PubMed, Scopus, and Google Scholar databases using key terms covering COVID‐19 vaccine, myocarditis, and cardiac MRI. Individual‐level patient data (IPD) and aggregated‐level data (AD) studies were pooled through a two‐stage analysis method. For this purpose, all IPD were first gathered into a single data set and reduced to AD, and then this AD (from IPD studies) was pooled with existing AD (from the AD studies) using fixed/random effect models. I 2 was used to assess the degree of heterogeneity, and the prespecified level of statistical significance ( P value for heterogeneity) was <0.1. Based on meta‐analysis of 102 studies ( n = 468 patients), 79% (95% confidence interval [CI]: 54%–97%) of patients fulfilled Lake Louise criteria (LLC) for diagnosis of myocarditis. Cardiac MRI abnormalities included elevated T2 in 72% (95% CI: 50%–90%), myocardial late gadolinium enhancement (LGE) in 93% (95% CI: 83%–99%; nearly all with a subepicardial and/or midwall pattern), impaired left ventricular ejection fraction (LVEF) (<50%) in 4% (95% CI: 1.0%–9.0%). Moreover, elevated T1 and extracellular volume fraction (ECV) (>30), reported only by some IPD studies, were detected in 74.5% (76/102) and 32% (16/50) of patients, respectively. In conclusion, our findings may suggest that over two‐thirds of patients with clinically suspected myocarditis following COVID‐19 vaccination meet the LLC. COVID‐19 vaccine‐associated myocarditis may show a similar pattern compared to other acute myocarditis entities. Notably, preserved LVEF is probably a common finding in these patients. Evidence Level 4 Technical Efficacy Stage 3

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

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Cardiac MRI Findings in COVID‐19 Vaccine‐Related Myocarditis: A Pooled Analysis of 468 Patients

Samimisedeh

Afshar

Hassani

et al. 2022

Magnetic Resonance Imaging

View full text Add to dashboard Cite

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“…Although BNT162b2 COVID-19 vaccination is safe and most of the adverse effects are mild [ 54 ], some moderate to serious adverse events such as anaphylaxis [ 24 , 25 , 26 , 27 ], thrombocytopenia [ 28 , 29 , 30 , 31 ], myocarditis [ 32 , 33 , 34 , 35 , 36 ], myositis [ 37 , 38 , 39 , 40 , 41 ] and rhabdomyolysis [ 42 , 43 , 44 ] were recently reported. Therefore, it is crucial to identify the factors associated with adverse effects after BNT162b2 vaccination.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, several mild to moderate rare cases of anaphylaxis [ 24 , 25 , 26 , 27 ], thrombocytopenia [ 28 , 29 , 30 , 31 ], myocarditis [ 32 , 33 , 34 , 35 , 36 ], myositis [ 37 , 38 , 39 , 40 , 41 ], and rhabdomyolysis [ 42 , 43 , 44 ] associated with the BNT162b2 vaccine have been reported. Here, we report a rare case of BNT162b2 vaccine-associated myositis in which the patient was severely affected.…”

Section: Introductionmentioning

confidence: 99%

Clinical and Molecular Characterization of a Rare Case of BNT162b2 mRNA COVID-19 Vaccine-Associated Myositis

et al. 2022

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Initial clinical trials and surveillance data have shown that the most commonly administered BNT162b2 COVID-19 mRNA vaccine is effective and safe. However, several cases of mRNA vaccine-induced mild to moderate adverse events were recently reported. Here, we report a rare case of myositis after injection of the first dose of BNT162b2 COVID-19 mRNA vaccine into the left deltoid muscle of a 34-year-old, previously healthy woman who presented progressive proximal muscle weakness, progressive dysphagia, and dyspnea with respiratory failure. One month after vaccination, BNT162b2 vaccine mRNA expression was detected in a tissue biopsy of the right deltoid and quadriceps muscles. We propose this case as a rare example of COVID-19 mRNA vaccine-induced myositis. This study comprehensively characterizes the clinical and molecular features of BNT162b2 mRNA vaccine-associated myositis in which the patient was severely affected.

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Global reports of myocarditis following COVID-19 vaccination: A systematic review and meta-analysis

Ahmed

Mohamed

Essa³

et al. 2022

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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Acute myocarditis after a third dose of the BNT162b2 COVID-19 vaccine

Cited by 8 publications

References 5 publications

Cardiac MRI Findings in COVID‐19 Vaccine‐Related Myocarditis: A Pooled Analysis of 468 Patients

Cardiac MRI Findings in COVID‐19 Vaccine‐Related Myocarditis: A Pooled Analysis of 468 Patients

Clinical and Molecular Characterization of a Rare Case of BNT162b2 mRNA COVID-19 Vaccine-Associated Myositis

Global reports of myocarditis following COVID-19 vaccination: A systematic review and meta-analysis

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