Acute Myocardial Infarction in Human Immunodeficiency Virus–Infected Patients

Matetzky, Shlomo; Domingo, Michelle; Kar, Saibal; Noč, Marko; Shah, Prediman K.; Kaul, Sanjay; Daar, Eric S.; Cercek, Bojan

doi:10.1001/archinte.163.4.457

Cited by 96 publications

(68 citation statements)

References 22 publications

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“…[11][12][13][14][15] These studies demonstrated that HIVinfected patients had the same treatment at the acute phase, but that the rates of recurrent AMI and urgent percutaneous coronary intervention (PCI) during follow-up were higher than in HIV-uninfected patients. Unfortunately, in-hospital mortality could not be studied because there were too few patients (between 20 and 103).…”

Section: Clinical Perspective On P 1774mentioning

confidence: 99%

“…Unfortunately, in-hospital mortality could not be studied because there were too few patients (between 20 and 103). [11][12][13][14][15][16][17] The main objective of the present study was to determine the influence of HIV infection on in-hospital mortality within a large national cohort of patients with AMI. The second objective was to compare the 1-year prognosis in HIV-infected patients with that in HIVuninfected patients.…”

Section: Clinical Perspective On P 1774mentioning

confidence: 99%

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Outcomes After Acute Myocardial Infarction in HIV-Infected Patients

et al. 2013

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Background— We aimed to assess in-hospital case fatality and 1-year prognosis in HIV-infected patients with acute myocardial infarction. Methods and Results— From the PMSI (Program de Medicalisation des Systèmes d’informatique) database, data from 277 303 consecutive acute myocardial infarction patients hospitalized from January 1, 2005, to December 31, 2009, were analyzed. Surviving patients were followed up for 1 year after discharge. HIV-infected patients were compared with uninfected patients. Among the cohort, HIV-infected patients (n=608) accounted for 0.22%. All-cause hospital and 1-year mortality rates were lower in the HIV-infected group than in uninfected patients (3.1% versus 8.1% [ P <0.001] and 1.4% versus 5.5% [ P <0.001], respectively). From the database, we then analyzed a cohort derived from a matching procedure, with 1 HIV patient matched with 2 patients without HIV, based on age and sex (n=1824). Ischemic cardiomyopathy was more frequent in the HIV group (7.6% versus 4.2%, P =0.003). Hospitalization and 1-year mortality rates were similar in the 2 groups (3.1% versus 2.1% [ P =0.168] and 1.4% versus 1.7% [ P =0.642], respectively). However, at 12 months, hospitalizations for episodes of heart failure were significantly more frequent in HIV-infected than in uninfected patients (3.3% versus 1.4%, respectively; P =0.020). HIV infection, diabetes mellitus, history of ischemic cardiomyopathy, and undergoing percutaneous coronary intervention were associated in univariate analysis with occurrence of heart failure. By multivariable analysis, HIV infection (odds ratio 2.82, 95% confidence interval 1.32–6.01), diabetes mellitus, and undergoing percutaneous coronary intervention remained independent predictors of heart failure. Conclusions— The present study demonstrates that after acute myocardial infarction, HIV status influences long-term risk, although the short-term risk in HIV patients is comparable to that in uninfected patients.

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Section: Clinical Perspective On P 1774mentioning

confidence: 99%

Section: Clinical Perspective On P 1774mentioning

confidence: 99%

Outcomes After Acute Myocardial Infarction in HIV-Infected Patients

et al. 2013

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“…It is usually more difuse and is associated with circumferential-intimal thickening, atherosclerotic plaques and abnormal proliferation of the smooth muscle. The muscles with luminal protrusions share several similarities with cardiac transplant vasculopathy [34][35][36][37][38]. Reports have suggested that the most common initial presentation of the HIV patient with CAD is acute myocardial infarction and its mortality can go as high as 24%.…”

Section: Hiv and Atherosclerotic Coronary Artery Diseasementioning

confidence: 99%

HIV-Associated Vasculopathy

Alqaqa¹

2017

HIV/AIDS - Contemporary Challenges

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HIV vasculopathy is a wide range of clinical spectrum related to HIV infection. Increasing longevity of HIV-infected individuals secondary to antiretroviral therapy advancements has resulted in increasing the number of patients with HIV-related vasculopathy. Clinicians need to be aware of the diferent types of HIV vasculopathy to be able to diagnose and manage the pathology and improve patient care.

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“…Los pacientes con factores de riesgo adicionales -como hipertensión, diabetes, tabaquismo e hiperhomocisteinemia-pueden tener un riesgo mayor para desarrollar síndromes coronarios agudos o infartos cerebrales, por la acelerada aterosclerosis que en ellos se produce (2,14,(17)(18)(19)(20)(21)(22) .…”

Section: Infarto Agudo De Miocardiounclassified

Patología cardiovascular en pacientes con infección por el virus de inmunodeficiencia humana

Valenzuela-Rodríguez

2013

An Fac med

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ResumenLa infección por el virus de inmunodeficiencia humana (VIH) estuvo asociada a un incremento de la morbimortalidad, dado que inducía un estado de inmunosupresión severa, la cual facilitaba la aparición de infecciones oportunistas. Sin embargo, posterior a la aparición y al uso de la terapia antirretroviral de gran actividad (TARGA), los pacientes infectados han experimentado una disminución de mortalidad asociada a infecciones, un incremento de la sobrevida y un incremento de enfermedades cardiovasculares. La etiología de estas enfermedades podría estar relacionada con la infección por sí misma, con condiciones proaterogénicas asociadas al empleo de determinados grupos de fármacos antirretrovirales, o con otros eventos adversos que estos serían capaces de inducir individualmente o al combinarse con otros medicamentos. Considerando que la mayoría de condiciones asociadas al compromiso cardiovascular en pacientes con VIH tiene inicio agudo, presentamos esta minuciosa revisión para reconocerlas en las salas de emergencia, eligiendo el tratamiento oportuno y excluyendo los tratamientos inapropiados. Palabras clave: Corazón, HIV, enfermedades cardiovasculares, síndrome de inmunodeficiencia adquirida. Abstract Human immunodeficiency virus (HIV) infection increases both morbidity and mortality by inducing severe immunosupression that generates opportunistic infections. Following use of high active antiretroviral therapy (HAART) in infected patients, infection-related mortality has decreased and both survival and cardiovascular disease have increased. The etiology of cardiovascular disease could be related to either infection itself, proatherogenic conditions associated with antiretroviral therapy or other adverse events caused by these therapies or by combination with other drugs. As most conditions associated with cardiovascular disease have an acute onset, we present this review for their recognition in the emergency ward, choosing opportune treatment and excluding inappropiate ones.

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Acute Myocardial Infarction in Human Immunodeficiency Virus–Infected Patients

Abstract: Patients infected with HIV sustain AMI at a young age and have a benign in-hospital course. Although HIV-infected patients have a higher incidence of postdischarge ischemic events, restenosis, and stent thrombosis, the intermediate-term mortality is low.

Cited by 96 publications

References 22 publications

Outcomes After Acute Myocardial Infarction in HIV-Infected Patients

Outcomes After Acute Myocardial Infarction in HIV-Infected Patients

HIV-Associated Vasculopathy

Patología cardiovascular en pacientes con infección por el virus de inmunodeficiencia humana

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