Acute Myocardial Infarction Biosensor: A Review From Bottom Up

Reyes-Retana, J.A.; Duque-Ossa, L. C.

doi:10.1016/j.cpcardiol.2020.100739

Cited by 30 publications

(22 citation statements)

References 217 publications

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“…Primary percutaneous coronary intervention (PPCI) is the gold standard for the treatment of ST segment elevation myocardial infarction (STEMI) because it results in the timely opening of the occluded coronary arteries [1]. Fresh blood flow is restored in >90% of STEMI patients after PPCI.…”

Section: Introductionmentioning

confidence: 99%

Coronary Endothelium No‐Reflow Injury Is Associated with ROS‐Modified Mitochondrial Fission through the JNK‐Drp1 Signaling Pathway

Chen

Liu

Zhou

et al. 2021

Oxidative Medicine and Cellular Longevity

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Coronary artery no-reflow is a complex problem in the area of reperfusion therapy, and the molecular mechanisms underlying coronary artery no-reflow injury have not been fully elucidated. In the present study, we explored whether oxidative stress caused damage to coronary endothelial cells by inducing mitochondrial fission and activating the JNK pathway. The hypoxia/reoxygenation (H/R) model was induced in vitro to mimic coronary endothelial no-reflow injury, and mitochondrial fission, mitochondrial function, and endothelial cell viability were analyzed using western blotting, quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA), and immunofluorescence. Our data indicated that reactive oxygen species (ROS) were significantly induced upon H/R injury, and this was followed by decreased endothelial cell viability. Mitochondrial fission was induced and mitochondrial bioenergetics were impaired in cardiac endothelial cells after H/R injury. Neutralization of ROS reduced mitochondrial fission and protected mitochondrial function against H/R injury. Our results also demonstrated that ROS stimulated mitochondrial fission via JNK-mediated Drp1 phosphorylation. These findings indicate that the ROS-JNK-Drp1 signaling pathway may be one of the molecular mechanisms underlying endothelial cell damage during H/R injury. Novel treatments for coronary no-reflow injury may involve targeting mitochondrial fission and the JNK-Drp1 signaling pathway.

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Section: Introductionmentioning

confidence: 99%

Coronary Endothelium No‐Reflow Injury Is Associated with ROS‐Modified Mitochondrial Fission through the JNK‐Drp1 Signaling Pathway

Chen

Liu

Zhou

et al. 2021

Oxidative Medicine and Cellular Longevity

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“…Acute myocardial infarction (AMI) is one of the main causes of death in cardiovascular diseases. [1][2][3][4] Cardiac troponin is an important biomarker of myocardial injury and is the laboratory gold standard of myocardial infarction diagnosis. 5,6 Cardiac troponin is released into the bloodstream from damaged cardiomyocytes when myocardial infarction occurs.…”

Section: Introductionmentioning

confidence: 99%

A novel photoelectrochemical sensor based on SiNWs@PDA for efficient detection of myocardial infarction

Zhi

Zhang

et al. 2022

Biomater. Sci.

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“…Myocardial infarction (MI) is a common cardiovascular disease that causes irreversible damage to the myocardium due to hypoxia 23 , 4,16 .It has been shown that MI is one of the most common causes of morbidity and death in the world, and more than one-third of deaths in developed countries are caused by MI each year 12,32 . At present, the main clinical therapy for coronary heart disease is thrombolysis and surgical therapy 22 .…”

Section: Introductionmentioning

confidence: 99%

Role of Global Longitude Strain related miRNAs as potential prognostic indicators in myocardial infarction

Chen¹,

Huang²,

Liu³

et al. 2022

Preprint

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BACKGROUND Real-time three-dimensional spot tracking echocardiography (RT3D-STE) can be used to assess the prognosis of myocardial infarction (MI). Analyzing the correlation between miRNAs and RT3D-STE, especially miRNAs and Global Longitude Strain (GLS) and Global Circumferential Strain (GCS), can provide new ideas for discovering and evaluating the role of miRNAs in assessing myocardial function and prognosis of MI. METHODS The present study collected forty-nine (49) plasma samples (15 normal samples and 34 MI samples; 22 before and 12 after intervention therapy) and employed high-throughput sequencing technology and real-time quantitative polymerase chain reaction (qRT–PCR) to identify the differentially expressed miRNAs. The Pearson correlation coefficient was used to measure the strength of a linear association between differentially expressed miRNAs and strain parameters of RT3D-STE. RESULTS One hundred forty-one (141) differentially expressed plasma exosome miRNAs were identified in STEMI compared with NSTEMI. The target genes of these ten miRNAs were analyzed for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment, and they were found to be involved mainly in cellular metabolism processes, HIF-1 signaling pathway, and the FoxO signaling pathway. Moreover, three of these differentially expressed miRNAs (hsa-miR-4798-3p, hsa-miR-371a-3p and hsa-miR-4735-5p) had Pearson correlations greater than 0.5 based on GLS. CONCLUSION Differentially expressed miRNAs obtained before and after surgical therapy of MI may play important roles in the occurrence and development of MI. hsa-miR-4798-3p, hsa-miR-371a-3p, and hsa-miR-4735-5p may be used as potential prognostic indicators of MI.

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Acute Myocardial Infarction Biosensor: A Review From Bottom Up

Cited by 30 publications

References 217 publications

Coronary Endothelium No‐Reflow Injury Is Associated with ROS‐Modified Mitochondrial Fission through the JNK‐Drp1 Signaling Pathway

Coronary Endothelium No‐Reflow Injury Is Associated with ROS‐Modified Mitochondrial Fission through the JNK‐Drp1 Signaling Pathway

A novel photoelectrochemical sensor based on SiNWs@PDA for efficient detection of myocardial infarction

Role of Global Longitude Strain related miRNAs as potential prognostic indicators in myocardial infarction

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