Acute myocardial infarction and pulmonary tuberculosis in a young female patient: a case report

Bakalli, Aurora; Osmani, Behxhet; Kamberi, Lulzim; Pllana, Ejup

doi:10.1186/1757-1626-1-246

Cited by 9 publications

(3 citation statements)

References 9 publications

(10 reference statements)

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“…Two main mechanisms have been suggested including increase in inflammation resulting in plaque formation and/or rapture and autoimmune phenomena [10].Our patient had some traditional risk factors for myocardial infarction including male gender, older age and hypertension and was diagnosed with active TB. There are several case reports of active TB and acute myocardial infarction including one case of a young female from Kosova with no known risk factors for ischemic heart disease suggesting TB as a potential pathogenic factor [11]. The presentation of TB with acute myocardial infarction (AMI) and aneurysm of the cardiac wall has as well been reported previously.…”

Section: Discussionmentioning

confidence: 75%

Miliary Tuberculosis and Acute Myocardial Infarction with left ventricular aneurysm in a 73 year old male seen at the National Hospital in Timor-Leste-A case report

Babua¹,

Monteiro²,

Seixas³

et al. 2019

APJHS

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Background:The developing world is currently facing a double epidemic of communicable and non-communicable diseases. There is a growing body of knowledge recognizing an interaction between the two epidemics. Here we report a case of active pulmonary tuberculosis and acute myocardial infarction. Case presentation: A 73 year old male who had recently been diagnosed with hypertension but with an otherwise unremarkable past medical history presented to the emergency department of the Timor-Leste National Referral Hospital with chest pain and shortness of breath of one weeks duration. There was a positive history of intermittent fever, dry cough and weight loss over the preceding 3-4 weeks. His 12-lead electrocardiogram showed ST-segment elevation in the inferior leads and chest X-ray was characteristic of miliary tuberculosis. Echocardiography showed low ejection fraction and left ventricular inferior wall aneurysm. Cardiac enzymes as well as cardiac catheterization were not available in the hospital. He was managed with medical therapy for myocardial infarction without reperfusion therapy. He initially showed improvement in his clinical parameters (Chest pain, Heart rate, Blood pressure, Oxygen saturations, and fever) but succumbed to sudden cardiac arrest after 10 days of hospital admission. Post mortem examination was not done. Conclusion: The presentation of acute myocardial infarction in this patient with active tuberculosis and an otherwise benign past medical history is in support of reports that tuberculosis plays an active role in the pathogenesis of acute myocardial infarction in some patients presenting with these two diseases.

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Section: Discussionmentioning

confidence: 75%

Miliary Tuberculosis and Acute Myocardial Infarction with left ventricular aneurysm in a 73 year old male seen at the National Hospital in Timor-Leste-A case report

Babua¹,

Monteiro²,

Seixas³

et al. 2019

APJHS

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“…Tuberculosis is also known to increase myocardial infarction rates, as demonstrated in a Taiwanese retrospective cohort, in which the TB group was 40% more likely to have had myocardial infarction [14] . Possible mechanisms of cardiovascular disease related to TB include indirect damage caused by systemic inflammation as well as direct injury of the heart [6] , [15] . Although rare, the latter has been shown in case reports of post-mortem histologic analyses of the heart [16] .…”

Section: Discussionmentioning

confidence: 99%

Resolution of coronary arteritis following tuberculosis treatment

Barreto-Neto¹,

Segre²,

Guedes³

et al. 2022

Journal of Clinical Tuberculosis and Other Mycobacterial Diseas

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Background Coronary artery aneurysm (CAA) in an uncommon condition usually associated with atherosclerosis, but systemic vasculitides constitute important differential diagnoses. A less recognized cause of CAA, tuberculosis (TB) has also been noted to occur simultaneously in patients with such vascular abnormalities. Case report A 60-year-old female presented to the Emergency Department with a non-ST segment elevation myocardial infarction. Angiography demonstrated segmental aneurysms of the left anterior descending coronary artery. Shortly after, she was also diagnosed with cutaneous TB, and treatment was promptly initiated. Reevaluation conducted several months later demonstrated that levels of inflammation markers had significantly decreased. New catheterization of coronary arteries evidenced complete resolution of coronary aneurysm images. Conclusion Due to the clinical and radiologic resolution with only TB treatment, as well as lack of evidence supporting atherosclerotic or vasculitic etiologies, TB can be considered a possible contributor to aneurysm formation in this case. Prospective studies are necessary to reliably demonstrate causality between TB infection and CAA.

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“…A recent nationwide population-based cohort study has provided compelling evidence that tuberculosis patients are at higher risk of developing acute coronary syndrome (ACS), and that the risk increases with age (40). In addition, Bakalli et al (41) showed a rare case of AMI in a 30-year-old female patient with PTB. Kinare et al (42) reported a severe case of a 19-year-old male who died due to a large ventricular aneurysm obtained from myocardial infarction caused by tuberculous coronaritis of the LAD branch.…”

Section: Discussionmentioning

confidence: 99%

Acute Myocardial Infarction in a Young Man with Hyperhomocysteinemia and Pulmonary Tuberculosis

Ren

Zhang

et al. 2016

Intern. Med.

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Acute myocardial infarction, hyperhomocysteinemia and pulmonary tuberculosis (PTB) are rare in individuals under the age of 30 years. We herein report the case of a 27-year-old man who presented with intermittent chest pain, elevated homosysteine level, and PTB. The patient was treated successfully with a combination of medications and percutaneous coronary intervention. This uncommon case highlights that homocysteine, folate and B vitamins levels should be regularly evaluated, and that chest X-rays or thoracic computed tomography should be ordered routinely to exclude PTB in patients under the age of 30 years who present acute myocardial infarction and lack the traditional risk factors.

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Acute myocardial infarction and pulmonary tuberculosis in a young female patient: a case report

Cited by 9 publications

References 9 publications

Miliary Tuberculosis and Acute Myocardial Infarction with left ventricular aneurysm in a 73 year old male seen at the National Hospital in Timor-Leste-A case report

Miliary Tuberculosis and Acute Myocardial Infarction with left ventricular aneurysm in a 73 year old male seen at the National Hospital in Timor-Leste-A case report

Resolution of coronary arteritis following tuberculosis treatment

Acute Myocardial Infarction in a Young Man with Hyperhomocysteinemia and Pulmonary Tuberculosis

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