Adverse reactions to ophthalmic patients during 9909 fluorescein angiographies during 9 years were registered. Nausea (4.6%) and vomiting (1.3%) wem the most common untoward reactions. Allergic skin manifestations occurred in 48 patients, and 5 patients coniplained of shortness of breath. 56 patients (0.6%) felt dixy during or immediately after the investigation. Nine patients complained of chest pain, three of whom developed myocardial infarction.Sixteen patients collapsed during the procedure. One healthy male, 42-year-old, collapsed after the injection of fluorescein during angiography, and electrocardiogram showed an asystole of 24 seconds. Otherwise, the electrocardiograms registered on 100 consecutive patients did not reveal any systematic changes in heart rate or rhythm during fluorescein angiography.