Acute myelomonocytic leukemia terminating in histiocytic medullary reticulosis.Cytochemical, cytogenetic and electron microscopic studies

Histiocytic medullary reticulosis occurring with small cell lung carcinoma

“…The simultaneous occurrence of these two aggressive d1sorders is unlikely to be coincidental and raises questi?ns about ~eir relationship. Most of the previously descnbed mahgnant conditions associated with haematophagocytic syndrome were of lymphoid [3][4][5][6][7][8][9][10][11] or haematopoietic [12][13][14] lineage but in few cases mediastinal germ cell tumour [18,19] and carcinoma of va?ous origins have also been reported [17, [19][20][21][22].…”

“…Eur Respir J., 1991, 4, 122-124. Histiocytic medullary reticulosis (HMR) is pathologically characterized by widespread tissue infiltration by atypical histiocytes demonstrating haematophagocytosis [1,2]. Recently an increasing number of HMR has been reported in association with various malignancies mostly of lymphoid [3-ll] or haematopoietic lineage [12][13][14]. Such a haematophagocytic syndrome may include two distinct entities: malignant histiocytosis and a benign (but potentially fatal) reactive histiocytic process mimicking the malignant form.…”

Concurrent T‐cell lymphocytic lymphoma and malignant histiocytosis

“…Over the last 15 years there have been reports linking various lymphoreticular malignancies with a malignant histiocytosis-like syndrome (Clark & Dawson 1969, Skarim, Karb & Reynolds 1972, Warnke, Kim & Dorfman 1975, Shreiner 1975, Chen et al 1976, Castoldi et al 1977, Chesney 1977, Lampert, Catovsky & Bergier 1978, Skoog & Feagler 1978, Griffin et al 1978, Karcher, Head & Mullins 1978, Trubowitz, Sobel & David 1980, Starkie 1981. However, with better definition of the cytological features of malignant histiocytosis and description of the virus associated haemophagocytic syndrome (Risdell et al 1979, Manoharan & Catovsky 1981 it has become clear that perhaps the majority of the reported cases are examples of the latter.…”