Concurrent T‐cell lymphocytic lymphoma and malignant histiocytosis

Abstract

A case in which both malignant histiocytosis and T-cell lymphocytic lymphoma occurred together is presented. Examples of malignant histiocytosis-like syndromes associated with lymphoreticular malignancies have been previously reported. Many of these represent reactive haemophagocytic syndromes, probably virally induced. The considerable degree of cytological atypia and frequent mitotic figures seen in the histiocytes in this case were indicative of a true malignant histiocytosis.

Lymphoma Associated Haemophagocytic Syndrome – A Diagnostic Trap

“…Rarely, the two malignancies may co-exist. 11 This case underlines the importance of suspecting HPS with the described constellation of clinical features. Early biopsy facilitates correct diagnosis and prompt initiation of specific therapy, depending on the underlying cause.…”

Ultrastructural pathology of cutaneous tumours of northern pike, Esox lucius L.

“…The present results obviate the need to establish marker profiles of haemic cells in Esox and other fish. However, T-cell and histiocytic neoplasms often share similar phenotypic profiles in humans (Adams et al 1984;Isaacson 1985;O'Brien, Child, Stark, Lauder & Bird 1985). On the basis of marker studies (Thompson & Kostiala 1986Kostiala & Thompson 1987), the T-lymphocytic origin of the Aland pike neoplasm remains a possibility.…”

Malignant Lymphomas: Pathology of Hepatic Involvement

“…An erroneous diagnosis of malignant histiocytosis is often made on liver biopsy. 80,81 This is particularly true if there is a concomitant lymphoid m a l i g n a n~y .~~ The hemophagocytic syndrome is often associated with Tcell malignancies. Because of the propensity for T-cell lymphomas to involve hepatic sinusoids, the sinusoids may contain both activated phagocytic histiocytes and malignant lynlphoid cells.…”