Acute myeloid leukemia presenting as granulocytic sarcoma of the lung

Wong, K. F.; Chan, John K. C.; Chan, Jane; Lam, Selay

doi:10.1002/ajh.2830430124

Cited by 10 publications

(1 citation statement)

References 7 publications

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“…A literature search revealed 27 other reported cases of intrathoracic myelocytic sarcomas, with 6 cases causing superior vena cava syndrome 4,5,[11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] (Table 1). Of the 28 reported cases, 13 patients (46%) responded to treatment, 11 (39%) died, 1 patient signed out against medical advice before receiving treatment, and in the other 3, the clinical course was not reported.…”

Section: Discussionmentioning

confidence: 98%

Intrathoracic Myeloid Sarcoma

Corla-Souza¹,

Kolitz²,

Shah³

et al. 2005

Journal of Bronchology

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Myeloid sarcoma, previously called granulocytic sarcoma or chloroma, is an extramedullary manifestation of leukemia, most often seen in the monocytic form of acute myeloid leukemia (AML). Myeloid sarcoma may arise before, concurrent with, or after the diagnosis of AML, chronic myelogenous leukemia (CML), or myelodysplastic syndrome (MDS) is made. Common sites of involvement include cutaneous or gingival infiltration of leukemic cells, lymph nodes, small intestine, mediastinum, epidural sites, uterus, and ovary. We report a patient with monoblastic sarcoma, an uncommon variant of noncutaneous, extramedullary acute leukemia that is exclusively of monoblastic derivation. The patient presented with lung involvement, mediastinal lymphadenopathy, pleural effusion, and superior vena cava (SVC) syndrome. He also had tracheobronchial tree compression. His symptoms responded to chemotherapy. We believe ours is the first case of monoblastic sarcoma involving the lung. The relevant literature dealing with intrathoracic myelocytic sarcoma is also reviewed.

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