ACUTE MYELOBLASTIC LEUKAEMIA AND t(8;21) TRANSLOCATION

The eosinophilias, including the idiopathic hypereosinophilic syndrome

“…AML M2 with the t(8;21) has mature eosinophils and their precursors in the marrow (Kaneko et al , 1983; Ishibashi et al , 1986), and less commonly in the blood (Jacobsen et al , 1984). FAB‐type M4 eo associated with chromosome 16 inversion shows a significant increase in bone marrow eosinophils and, although eosinophils may be present in the blood, their numbers are not markedly increased (Nakamura et al , 1987).…”

Transcription factor fusions in acute leukemia: variations on a theme

“…The t(8;21) translocation is found predominantly in the FAB M2 subtype of AML (Mrozek et al, 2001). These myeloblasts usually show`aberrant' expression of CD19, have a predisposition to form granulocytic sarcomas, and are associated with eosinophilia (Andrieu et al, 1996;Jacobsen et al, 1984;Swirsky et al, 1984). t(8;21) positive AML has a good prognosis in adults, although the expression of CD56, a marker of natural killer cells, is sometimes seen and may portend a poorer outcome (Baer et al, 1997;Byrd and Weiss, 1994).…”