The eosinophilias, including the idiopathic hypereosinophilic syndrome

Brito‐Babapulle, Finella

doi:10.1046/j.1365-2141.2003.04195.x

Cited by 191 publications

(181 citation statements)

References 287 publications

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“…In healthy individuals, eosinophilic granulocytes (eosinophils) constitute <5% of all white blood cells [1]. Blood eosinophilia, traditionally defined for use in clinical practice as an eosinophil count of 0.5 3 10 9 /l, is encountered in all areas of medicine and in both primary and secondary care.…”

Section: Introductionmentioning

confidence: 99%

“…Reactive causes account for the vast majority of cases. A plethora of distinct disease entities with concomitant eosinophilia has been known for many years, whereas the primary eosinophilic conditions were not introduced until 1968 [1,5,6]. Advances in cytogenetic, and in particular molecular techniques, have recently identified specific lymphoid and myeloid neoplasms with eosinophilia, hereby categorizing clonal markers in these entities [3,4,7].…”

Section: Introductionmentioning

confidence: 99%

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Association of the blood eosinophil count with hematological malignancies and mortality

et al. 2015

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Blood eosinophilia (≥0.5 × 109/l) may be an early sign of hematological malignancy. We investigated associations between levels of blood eosinophils and risks of hematological malignancies and mortality in order to provide clinically derived cut‐offs for referral to specialist hematology care. From the Copenhagen Primary Care Differential Count (CopDiff) Database, we identified 356,196 individuals with at least one differential cell count encompassing the eosinophil count during 2000–2007 and matched these laboratory data with Danish nationwide health registers. We used multivariable logistic regression to calculate odds ratios (ORs) for the 4‐year incidences of hematological malignancies and mortality between the eosinophil counts and a reference count of 0.16 × 109/l which was the median eosinophil count in our data. Risks of hematological malignancies and mortality increased above the median eosinophil count. At the 99th percentile, corresponding to an eosinophil count of 0.75 × 109/l, risks of hematological malignancies were increased more than twofold with OR (95% C.I.) of 2.39 (1.91–2.99). Interestingly, risks reached a plateau around an eosinophil count of 1.0 × 109/l. Risks also increased when the eosinophil count approached zero. Here, counts associated relatively more with acute myeloid leukemia and myelodysplastic syndromes whereas counts above 0.16 × 109/l associated more with myeloproliferative neoplasms. Eosinophil counts associate with hematological malignancies and mortality even below the definition of eosinophilia. The observed plateau of risks around 1.0 × 109/l is important for physicians encountering patients with eosinophilia since even mild‐to‐moderate eosinophilia according to traditional definitions confers maximally increased risks of subsequent/subclinical hematological malignancy. Am. J. Hematol. 90:225–229, 2015. © 2014 Wiley Periodicals, Inc.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of the blood eosinophil count with hematological malignancies and mortality

et al. 2015

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“…Eosinophilia is a hallmark of the acute phase of schistosomiasis -Eosinophils represent a minor cell type among leukocytes, with basal counts ranging from 400-600 cells/mm 3 (Brito-Babapulle 2003). In this study, acute schistosomiasis patients had a significantly higher number of eosinophils.…”

Section: Discussionmentioning

confidence: 49%

Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni

Silveira-Lemos

Teixeira-Carvalho²,

Martins‐Filho³

et al. 2010

Mem. Inst. Oswaldo Cruz

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The recruitment of circulating eosinophils by chemokines and chemokine receptors plays an important role in the inflammation process in acute human schistosomiasis. Our main focus has been on the plasma chemokines (CXCL8/CCL2/CCL3/CCL24) and chemokine receptors (CCR2/CCR3/CCR5/CXCR1/CXCR2/CXCR3/CXCR4) expressed by circulating eosinophils from acute Schistosoma mansoni infected patients (ACT). Our studies compared ACT patients and healthy individuals as a control group. Our major findings demonstrated a plethora of chemokine secretion with significantly increased secretion of all chemokines analysed in the ACT group. Although no differences were detected for beta-chemokine receptors (CCR2, CCR3 and CCR5) or alpha-chemokine receptors (CXCR3 and CXCR4), a significantly lower frequency of CXCR1+ and CXCR2+ eosinophils in the ACT group was observed. The association between chemokines and their chemokine receptors revealed that acutely infected schistosome patients displaying decreased plasma levels of CCL24 are the same patients who presented enhanced secretion of CCL3, as well as increased expression of both the CCR5 and CXCR3 chemokine receptors. These findings suggest that CCL24 may influence the kinetics of chemokines and their receptors and eosinophils recruitment during human acute schistosomiasis mansoni

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“…The cytotoxic properties of the eosinophil cationic protein and major basic protein suggested that their extracellular deposition may contribute to vascular injury (Hällgren et al, 1991;Young et al, 1986). These eosinophil constituents have been demonstrated to be harmful to endothelial cells in vitro, thus suggesting they are etiological agents of vasculitis (Brito-Babapulle, 2003;Hällgren et al, 1991) or at least, contribute to the pathogenesis of the lesion.…”

Section: Discussionmentioning

confidence: 99%

“…These include major basic protein, eosinophilic cationic protein, and eosinophilic peroxidase. Each of these proteins has been cloned, and their biochemical and functional properties have been well studied (Brito-Babapulle, 2003;Sano et al, 2001;Weller et al, 1988). Eosinophils become activated, and acquire increased cytotoxic capacity.…”

Section: Introductionmentioning

confidence: 99%

The spectrum of eosinophilic infiltration of the cecum and its relationship to other disorders of multiple granulomas and arteritis in Sprague-Dawlay rat

Li¹,

Bae

Kim³

et al. 2014

J. Toxicol. Sci.

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-Spontaneous multiple granulomas were present in the animal under the SPF condition and without chemical treatment, in a 19-week-old male Sprague-Dawley control-group rat. Here we describe multiple granulomas and prominent diffuse infiltration by eosinophils in the cecal submucosa, and arteritis in the mesenteric arteries. The multiple granulomas were characterized by central eosinophilic degeneration or necrosis, prominent eosinophils, many multi-nucleated giant cells and abundant fibroblasts. They were restricted to the cecal submucosa. The mesenteric arteritis consisted of fibrinoid necrosis of the intima and media, intense inflammatory cell infiltration and fibrosis in the arterial wall. An affected artery in the cecum was continuous with the mesenteric artery. The foregoing tissue changes in this rat correlate with the high absolute blood eosinophil count found in this animal.

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The eosinophilias, including the idiopathic hypereosinophilic syndrome

Cited by 191 publications

References 287 publications

Association of the blood eosinophil count with hematological malignancies and mortality

Association of the blood eosinophil count with hematological malignancies and mortality

Seric chemokines and chemokine receptors in eosinophils during acute human schistosomiasis mansoni

The spectrum of eosinophilic infiltration of the cecum and its relationship to other disorders of multiple granulomas and arteritis in Sprague-Dawlay rat

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