Acute Lymphadenosis Compared With Acute Lymphatic Leukemia

Downey, Hal; McKinlay, C. A.

doi:10.1001/archinte.1923.00110190085006

Cited by 220 publications

(44 citation statements)

References 6 publications

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“…They illustrated the features of these mononuclear cells that distinguished them from leukemia. Several years later, Downey and McKinlay published a comprehensive description of the atypical lymphocytes seen in the peripheral blood of patients with infectious mononucleosis (44). As mentioned above, these atypical lymphocytes, also referred to as Downey cells, are activated CD8 T lymphocytes, most of which are thought to be responding to EBV-infected B cells.…”

Section: Nonspecific Laboratory Testsmentioning

confidence: 99%

Progress and Problems in Understanding and Managing Primary Epstein-Barr Virus Infections

2011

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SUMMARY Epstein-Barr virus (EBV) is a gammaherpesvirus that infects a large fraction of the human population. Primary infection is often asymptomatic but results in lifelong infection, which is kept in check by the host immune system. In some cases, primary infection can result in infectious mononucleosis. Furthermore, when host-virus balance is not achieved, the virus can drive potentially lethal lymphoproliferation and lymphomagenesis. In this review, we describe the biology of EBV and the host immune response. We review the diagnosis of EBV infection and discuss the characteristics and pathogenesis of infectious mononucleosis. These topics are approached in the context of developing therapeutic and preventative strategies.

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Section: Nonspecific Laboratory Testsmentioning

confidence: 99%

Progress and Problems in Understanding and Managing Primary Epstein-Barr Virus Infections

2011

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“…Four years later EBV was linked to Infectious Mononucleosis which is its most common clinical manifestation (Henle et al, 1968). The characteristic atypical lymphocytes which are carefully described morphologically by Downey and McKinlay (Downey et al, 1923) are actually activated CD8+T cells (Callan et al, 1996), which are responding to EBV-infected B cells (Callan et al, 1998). Infectious Mononucleosis represent a significant health risk because of the severity and duration of the acute illness and also because of the potential for longterm complications such as certain cancers and autoimmune diseases.…”

Section: Introductionmentioning

confidence: 99%

Emotional Disturbances in Children Hospitalized with Infectious Mononucleosis

2016

IJSR

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Infectious Mononucleosis is an acute infectious disease caused by Epstein-Barr virus (EBV). It is characterized by systemicsomatic complaints consisting primarily of fatigue, malaise, fever, sore throat, cervical lymphadenopathy and accompanied by atypical large peripheral blood lymphocytes. Anxiety disorder includes concern and excessive unhappiness or unrealistic over multiple life circumstances, where the individual predict that something dangerous or distressed will happen, things that he will not be able to control. The aim of this study is to explore emotional disturbance in hospitalized children infected with EBV.

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“…Sprunt and Evans (24) described the clinical features of infectious mononucleosis (IM) in 1920, and shortly thereafter Downey and McKinlay (3) added a detailed description of the hematological findings for the disease. In 1937, the heterophil antibody (HA) test with differential absorption was shown to detect IM-specific HA, providing a third criterion for the diagnosis of IM (2,19).…”

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confidence: 99%

Limitations of available tests for diagnosis of infectious mononucleosis

1984

Journal of Infection

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Among 500 students seen at a university health service for illnesses resembling infectious mononucleosis (IM), the Students with IM who showed a delayed emergence of the spectrum of EBVspecific antibodies characteristic of an acute infection were compared with control patients who had such antibodies at the time of their initial visit to the health service. They were found to have a briefer duration of illness (P > 0.05), lower leukocyte (P < 0.005), lymphocyte (P < 0.005), and atypical lymphocyte (P < 0.05) counts, and a less frequent occurrence of heterophil antibodies (P < 0.05).Sprunt and Evans (24) described the clinical features of infectious mononucleosis (IM) in 1920, and shortly thereafter Downey and

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Acute Lymphadenosis Compared With Acute Lymphatic Leukemia

Cited by 220 publications

References 6 publications

Progress and Problems in Understanding and Managing Primary Epstein-Barr Virus Infections

Progress and Problems in Understanding and Managing Primary Epstein-Barr Virus Infections

Emotional Disturbances in Children Hospitalized with Infectious Mononucleosis

Limitations of available tests for diagnosis of infectious mononucleosis

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