Acute lung injury after ruptured abdominal aortic aneurysm repair: The effect of excluding donations from females from the production of fresh frozen plasma*

Wright, Stephen E.; Snowden, Christopher; Athey, S; Leaver, Alice A.; Clarkson, Jill-Marie; Chapman, C.; Roberts, David R.; Wallis, Jonathan P.

doi:10.1097/ccm.0b013e3181743c6e

Cited by 79 publications

(70 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…27 Two clinical studies have appeared, indicating that excluding female donor plasma may prove effective in reducing pulmonary complications after blood transfusion. 28,49 Although the policy of excluding female donors for FFP products by the Dutch National Blood Bank did not result in a decrease in TRALI incidence in the present study, it should be noted that during the study period plasma of female donors was used for preparation of PLTs and RBC products. In accordance, the association with onset of TRALI was strongest for PLTs, which contain a high amount of plasma in the product.…”

Section: Discussionmentioning

confidence: 99%

The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study

Vlaar

Hofstra²,

Determann³

et al. 2011

Blood

184

176

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study

Vlaar

Hofstra²,

Determann³

et al. 2011

Blood

184

176

View full text Add to dashboard Cite

“…30 Several recent isolated studies have focused on high-risk surgical populations, which, coupled with differences in methodology and outcome adjudication, limits generalizability to the wider surgical population. 31,32 …”

Section: Discussionmentioning

confidence: 99%

Characterizing the Epidemiology of Postoperative Transfusion-related Acute Lung Injury

et al. 2015

View full text Add to dashboard Cite

Background Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-related death in the United States; however, it remains poorly characterized in surgical populations. To better inform perioperative transfusion practice, and to help mitigate perioperative TRALI, the authors aimed to better define its epidemiology before and after TRALI mitigation strategies were introduced. Methods This retrospective cohort study examined outcomes of adult patients undergoing noncardiac surgery with general anesthesia who received intraoperative transfusions during 2004 (n = 1,817) and 2011 (n = 1,562). The demographics and clinical characteristics of transfusion recipients, blood transfusion descriptors, and combined TRALI/possible TRALI incidence rates were evaluated. Univariate analyses were used to compare associations between patient characteristics, transfusion details, and TRALI mitigation strategies with TRALI/possible TRALI incidence rates in a before-and-after study design. Results The incidence of TRALI/possible TRALI was 1.3% (23 of 1,613) in 2004 versus 1.4% (22 of 1,562) in 2011 (P = 0.72), with comparable overall rates in males versus females (1.4% [23 of 1,613] vs. 1.2% [22 of 1,766]) (P = 0.65). Overall, thoracic (3.0% [4 of 133]), vascular (2.7% [10 of 375]), and transplant surgeries (2.2% [4 of 178]) carried the highest rates of TRALI/possible TRALI. Obstetric and gynecologic surgical patients had no TRALI episodes. TRALI/possible TRALI incidence increased with larger volumes of blood product transfused (P < 0.001). Conclusions Perioperative TRALI/possible TRALI is more common than previously reported and its risk increases with greater volumes of blood component therapies. No significant reduction in the combined incidence of TRALI/possible TRALI occurred between 2004 and 2011, despite the introduction of TRALI mitigation strategies. Future efforts to identify specific risk factors for TRALI/possible TRALI in surgical populations may reduce the burden of this life-threatening complication.

show abstract

“…The UK has taken the lead in restricting FFP and platelet products to male donors, which has led to a decrease in the passive reporting of TRALI in their Serious Hazards of Transfusion (SHOT) database [37 ]. In a study on the development of ALI after repair of ruptured abdominal aortic aneurysms, patients transfused FFP after the switch to male-only FFP developed less ALI than patients transfused FFP before plasma mitigation [38].…”

Section: Patient and Donor Risk Factorsmentioning

confidence: 98%

Pathophysiology of transfusion-related acute lung injury

Looney

Gilliss²,

Matthay³

2010

Current Opinion in Hematology

View full text Add to dashboard Cite

show abstract

Acute lung injury after ruptured abdominal aortic aneurysm repair: The effect of excluding donations from females from the production of fresh frozen plasma*

Abstract: The policy to exclude female donors from the production of fresh frozen plasma was associated with a decrease in the frequency of acute lung injury in patients undergoing repair of a ruptured abdominal aortic aneurysm.

Cited by 79 publications

References 33 publications

The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study

The incidence, risk factors, and outcome of transfusion-related acute lung injury in a cohort of cardiac surgery patients: a prospective nested case-control study

Characterizing the Epidemiology of Postoperative Transfusion-related Acute Lung Injury

Pathophysiology of transfusion-related acute lung injury

Contact Info

Product

Resources

About