Acute Localized Exanthematous Pustulosis Due to Bemiparin

Abstract

Palabras clave: Crisantemo. Inhalante. Dermatitis ocupacional de contacto. Dermatitis de contacto por proteínas. nSal k 1.

Acute generalized exanthematous pustulosis induced by enoxaparin: 2 cases

“…Only two cases of severe cutaneous adverse reactions related to heparins have been published: one of drug reaction with eosinophilia and systemic symptoms induced by enoxaparin (no skin tests performed) and one of AGEP induced by dalteparin, with polysensitization that relapsed during the subcutaneous tests (Table 1). 3,4 Two cases of acute localized exanthematous pustulosis, a variant of AGEP, have also been reported: one induced by bemiparin with a positive patch test and rechallenge, but without cross‐reactivity, and one induced by calcium heparin with previous similar episodes with enoxaparin and nadroparin 5,6 . Allergologic exploration is also needed to find safe alternatives in case of eczema localized at the injection site.…”

Acute localized exanthematous pustulosis: Clinical features, pathophysiology, and therapy

“…12,20 Levofloxacin, 26 sulfamethoxazoletrimethoprim, 22 iperacillin/tazobactam, 15 and clindamycine 13 have been reported in one case each. Drugs other than antibiotics have also been implicated in ALEP such as paracetamol, 27 ibuprofen, 11,23 allopurinol, 33 nimesulide, 28 docetaxel, 21 infliximab, 10 lamotrigine, 5 bemiparin, 9 finasteride, 18 sorafenib, 19 heparin calcium, 3 and metronidazole. 4 ALEP has long been considered a form of AGEP limited to one or few areas of the skin.…”

Acute localized exanthematous pustulosis induced by paclitaxel

“… 3 About 90% of cases are drug-induced, with antibiotics, especially beta-lactams and macrolides, being the most common causative drugs. 1 , 3 Associations with docetaxel, a chemotherapeutic drug of the taxane class, have also been reported in two patients with breast cancer. 4 , 5 …”

“…Acute localized exanthematous pustulosis (ALEP) is an atypical variant of acute generalized exanthematous pustulosis (AGEP), a rare drug reaction. 1 It is an acute, localized subcorneal aseptic pustular eruption, usually affecting the face, cervical region, or thorax. 2 , 3 The pathophysiological mechanisms remain unclear, although 90% of ALEP cases are drug-induced.…”

“…2 , 3 The pathophysiological mechanisms remain unclear, although 90% of ALEP cases are drug-induced. 1 This case report describes a paclitaxel-induced ALEP case in a patient undergoing breast cancer treatment.…”