Acute liver injury by vinyl chloride: involvement of endoplasmic reticulum in phenobarbital-pretreated rats.

Reynolds, Edward S.; Jaeger, Rudolph J.; Murphy, Sheldon D.

doi:10.1289/ehp.7511227

Cited by 7 publications

(2 citation statements)

References 15 publications

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“…These studies confirm the results reported by Reynolds et al (13), who described similar findings after rats treated with phenobarbital were given a single exposure to 50,000 ppm vinyl chloride. The lesions we found after phenobarbital-treated rats had received ten exposures to 13,500 ppm vinyl chloride were similar although perhaps not quite as severe as those seen by Reynolds after a single exposure to a higher concentration of vinyl chloride.…”

Section: Discussionsupporting

confidence: 92%

Effects of Vinyl Chloride Exposures to Rats Pretreated with Phenobarbital

Drew¹,

Harper²,

Talley³

1975

Environmental Health Perspectives

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JSTOR is a not-for-profit service that helps scholars, researchers, and students discover, use, and build upon a wide range of content in a trusted digital archive. We use information technology and tools to increase productivity and facilitate new forms of scholarship. For more information about JSTOR, please contact support@jstor.org.. The National Institute of Environmental Health Sciences (NIEHS) and Brogan & Partners are collaborating with JSTOR to digitize, preserve and extend access to Environmental Health Perspectives.Male rats were exposed to 10 consecutive days, 6 hr/day, to vinyl chloride vapors at an average concentration of 13,500 ppm. The exposed rats were divided into three groups of eight rats each: one group was pretreated with 3-methylcholanthrene, one group was pretreated with phenobarbital, and the third group received no treatment. Half the animals in each group were sacrificed 18 hr after the last exposure and half were sacrificed 4 days later. In a second experiment, four rats pretreated with phenobarbital were exposed to vinyl chloride vapors at a concentration of 17,300 ppm for 2 days and sacrificed about 9 A.M. on the third day. In both experiments control animals, also treated with phenobarbital or 3-methylcholanthrene, were exposed to air only. At the time of sacrifice, lungs, kidneys, spleen, heart, and a small piece of liver from each animal were preserved for histological examination. The remainder of the liver was processed for assay of microsomal enzyme activity.The following parameters were investigated: growth rate, organ weights, morphological changes, and both benzphetamine-N-demethylase activity and cytochrome P-450 content of microsomes prepared from the livers. In both experiments the only marked difference noted in any group was a decrease in the growth rate of the animals exposed to vinyl chloride and treated with phenobarbital. This decreased growth rate was particularly apparent on the third day of the vinyl chloride exposures. Occasional morphological changes were also seen in the livers of the animals treated with phenobarbital and exposed to vinyl chloride. AnimalsMale rats (Charles River CD-1) weighing between 200 and 250 g were used in these studies. They were housed in plastic cages with corncob bedding. Food (Wayne Lab Blox) and water were provided ad libitum except during the inhalation exposures. A 12-hr on-12-hr off light cycle was used in the animal quarters. ReagentsVinyl chloride (Linde Specialty Gas) was verified to be greater than 99.5% pure by gas chromatography and was used as supplied. June 1975 235This content downloaded from 91.

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Section: Discussionsupporting

confidence: 92%

Effects of Vinyl Chloride Exposures to Rats Pretreated with Phenobarbital

Drew¹,

Harper²,

Talley³

1975

Environmental Health Perspectives

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“…There is probably more toxicological information now on vinyl chloride (XI) than any other monomer (13,(18)(19)(20)(21)(22). For example, a recent paper on health effects of vinyl chloride monomer contains an annotated bibliography of some 162 references (19).…”

Section: Ch3 (> )~~~3 Cr-tricresyl Phosphatementioning

confidence: 99%

Chemistry and toxicity of flame retardants for plastics.

Liepins¹,

Pearce²

1976

Environ Health Perspect

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An overview of commercially used flame retardants is give. The most used flame retardants are illustrated and the seven major markets, which use 96% of all flame-retarded polymers, are described. Annual flame retardant growth rate for each major market is also projected. Toxicity data are reviewed on only those compositions that are considered commercially significant today. This includes 18 compounds or families of compounds and four inherently flame-retarded polymers. Toxicological studies of flame retardants for most synthetic materials are of recent origin and only a few of the compounds have been evaluated in any great detail. Considerable toxicological problems may exist in the manufacturing of some flame retardants, their by-products, and possible decomposition products.

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Vinylchlorid [MAK Value Documentation in German language, 1987]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 12. Lieferung, Ausgabe 1987 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Erfahrungen beim Menschen Tierexperimentelle Befunde Pharmakokinetik und Metabolismus Zur Frage eines MAK‐Wertes

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Acute liver injury by vinyl chloride: involvement of endoplasmic reticulum in phenobarbital-pretreated rats.

Cited by 7 publications

References 15 publications

Effects of Vinyl Chloride Exposures to Rats Pretreated with Phenobarbital

Effects of Vinyl Chloride Exposures to Rats Pretreated with Phenobarbital

Chemistry and toxicity of flame retardants for plastics.

Vinylchlorid [MAK Value Documentation in German language, 1987]

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