Acute liver failure and self-medication

Oliveira, André Vitorio Câmara de; Rocha, Frederico Theobaldo Ramos; Abreu, Silvio Romero de Oliveira

doi:10.1590/s0102-67202014000400016

Cited by 17 publications

(11 citation statements)

References 23 publications

(65 reference statements)

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“…In spite of the apparent controversial result, the wine worsened lipid metabolism of ApoE knockout mices. The limitation of this study may be exactly the use of these animals, that do not faithfully reproduce what may occur in hypercholesterolemy in humans 20 .…”

Section: Discussionmentioning

confidence: 99%

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Effect of Chronic Ingestion of Wine on the Glycemic, Lipid and Body Weight Homeostasis in Mice

Brito-Filho

Moura

Santos

et al. 2016

ABCD, arq. bras. cir. dig.

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Background: The health benefits associated with moderate wine consumption, as with ethanol and phenolic compounds, include different mechanisms still little understandable. Aim: Evaluate glycemic and weight variations, and the deposit of triglycerides, cholesterol and liver glycogen with red wine consumption. Methods: 60 ApoE knockout mice were divided into three groups of 20: Wine Group (WG), Ethanol Group (EG) and Water Group (WAG). They received daily: WG 50 ml of wine and 50 ml water; EG 6 ml ethanol and WAG 94 ml of water. All groups were followed for four months. The food intake was monitored daily, in the period from eight to ten hours and held every five days. The measurement of water intake was also made every five days. The weighing of the animals took place every ten days. Results: The WG had higher weight increase as compared to the other groups. The concentration of hepatic triglyceride was higher in WG (57%) and the EG group was lower (31.6%, p<0.01) than the control. The concentration of cholesterol was lower in the WG (23.6%), as well as EG (24.5%, p<0.05). The concentration of glycogen was higher in WG (16%) and fasting blood glucose was higher in EG compared to the other groups but not both demonstrated a statistically significant difference. Conclusion: The WG increased triglyceride and WAG decreased cholesterol. The triglyceride may be increased due to the high caloric value of wine or some unknown property that led to significant increase in subcutaneous andretroperitoneal fat in mice.

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Section: Discussionmentioning

confidence: 99%

“…The ApoE knockout mouse is more suitable for presenting a deficiency in the gene encoding ApoE and for being predisposed to hypercholesterolemia inducing atherosclerosis. This and an already validated model are widely used in trials 3 , 16 , 18 , 20 , 21 , 22 , 25 , 26 .…”

Section: Discussionmentioning

confidence: 99%

Effect of Chronic Ingestion of Wine on the Glycemic, Lipid and Body Weight Homeostasis in Mice

Brito-Filho

Moura

Santos

et al. 2016

ABCD, arq. bras. cir. dig.

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“…Hepatitis in pregnant women depends on several factors; it can manifest in the acute or chronic form and lead to liver damage, failure, or liver cancer [2]. Intrahepatic cholestasis of pregnancy is the most common specific liver disease observed and the second leading cause of jaundice during pregnancy, with an estimated incidence rate of approximately 1/10,000 deliveries [3].…”

Section: Introductionmentioning

confidence: 99%

Acute Hepatitis in Pregnancy: A Case Report

Amp¹,

Act²,

Apxp³

et al. 2020

Asp Biomed Clin Case Rep

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Introduction: Several changes occur in women’s body during pregnancy, as well as several pathologies can arise at this period, such as hepatitis. It is very important to have the correct diagnosis and proper treatment for pregnant women because liver diseases can increase maternal and/or fetal morbidity and mortality rates. Case Report: Patient in the age group 32 years, G2P0A1, thrombophilic, using ASA, enoxaparin, folate, and B-complex, reported jaundice, low fever, and pruritus in the 32nd week of pregnancy. Laboratory exams showed high levels of direct hyperbilirubinemia and aminotransferases, with negative serology results for the most common viruses and autoimmunity markers. Hypervitaminosis B12 was an additional finding; it was canceled. The patient had a satisfactory recovery after support treatment. Discussion: Hepatitis has several etiologies; it is caused by infections, medications, or triggered by the immune system. The main infectious agents causing hepatitis A, B, C, and E; Dengue, Zika, HTLV, cytomegalovirus, toxoplasmosis, rubella, and brucellosis were screened in the reported case – the patient was negative for all of them. Other possible diagnoses, such as acute liver steatosis of pregnancy, portal thrombosis, and autoimmune hepatitis were excluded. Hepatitis caused by medicines was not confirmed because clinical and laboratory exams showed improvement in the patient’s clinical condition even with ASA and enoxaparin administration. The patient had high vitamin B12 level, which can be a liver damage marker. Transaminases and bilirubin showed a progressive decrease after the treatment; both patient and newborn had a satisfactory recovery. The reported condition was caused by a combination of factors, such as pregnancy hormone levels, unidentified infection, and possible predisposition to develop the disease. The patient remains under hematological and hepatological follow up, but there is no record of relapse, so far.

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“…Those with liver cirrhosis have a 20% chance of developing the tumor in five years 6 . This high association defines the population of cirrhotic patients as risky, which must be followed through periodic screening, allowing the early diagnosis of the tumor 24 .…”

Section: Introductionmentioning

confidence: 99%

Comparative Study on Liver Transplantation With and Without Hepatocellular Carcinoma With Cirrhosis: Analysis of Meld, Waiting Time and Survival

Freitas¹,

Shiguihara²,

Monteiro³

et al. 2016

ABCD, arq. bras. cir. dig.

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Background : Liver transplantation is the usual treatment for hepatocellular carcinoma.Aim:To analyze the MELD score, waiting time and three month and one year survival for liver transplantation in cirrhotic patients affected by hepatocellular carcinoma or not. Methods : This was a retrospective, observational and analytical study of 93 patients submitted to liver transplantation. Results : There were 28 hepatocellular carcinoma and 65 non-hepatocellular carcinoma patients with no differences related to age and sex distribution. The main causes of cirrhosis on hepatocellular carcinoma were hepatitis C virus (57.1%) and hepatitis B virus (28.5%), more frequent than non-hepatocellular carcinoma patients, which presented 27.7% and 4.6% respectively. The physiological and exception MELD score on hepatocellular carcinoma were 11.9 and 22.3 points. On non-hepatocellular carcinoma, it was 19.4 points, higher than the physiological MELD and lower than the exception MELD on hepatocellular carcinoma. The waiting time for transplantation was 96.2 days for neoplasia, shorter than the waiting time for non-neoplasia patients, which was 165.6 days. Three month and one year survival were 85.7% and 78.6% for neoplasia patients, similar to non-neoplasia, which were 77% and 75.4%.Conclusion:Hepatocellular carcinoma patients presented lower physiological MELD score, higher exception MELD score and shorter waiting time for transplantation when compared to non-hepatocellular carcinoma patients. Three month and one year survival were the same between the groups.

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Acute liver failure and self-medication

Cited by 17 publications

References 23 publications

Effect of Chronic Ingestion of Wine on the Glycemic, Lipid and Body Weight Homeostasis in Mice

Effect of Chronic Ingestion of Wine on the Glycemic, Lipid and Body Weight Homeostasis in Mice

Acute Hepatitis in Pregnancy: A Case Report

Comparative Study on Liver Transplantation With and Without Hepatocellular Carcinoma With Cirrhosis: Analysis of Meld, Waiting Time and Survival

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