Acute left anterior descending artery occlusion in a hemophiliac A patient during recombinant factor VIII infusion: Treatment with coronary angioplasty

Abstract

Acute myocardial infarction in association with the replacement of recombinant factor VIII in hemophiliacs has not been documented. We describe the use of PTCA in a hemophiliac A patient who developed acute myocardial infarction during factor VIII replacement. Because surgery in hemophiliac A patients remains hazardous, PTCA seems to be an attractive alternative.

Coronary angiography with or without percutaneous coronary intervention in patients with hemophilia—Systematic review

“…The process of search and article selection is shown in Figure . Information for the present analysis was extracted from 29 articles (case reports and small case series) .…”

Prevalence and risk factors for heart disease among males with hemophilia

“…On the other hand, IHD and thrombosis in persons with hemophilia are thought to be related to factor VIII levels by some investigators [6,7]. Alsolaiman [7] reported coronary artery occlusion during recombinant FVIII infusion in a patient with hemophilia.…”

“…Alsolaiman [7] reported coronary artery occlusion during recombinant FVIII infusion in a patient with hemophilia. Coronary artery disease and myocardial infarction are well-described complications in patients with inhibitors and are presumed to be secondary to the administration of factor concentrates.…”

Acute Myocardial Infarction Due to Elevated Levels of Factor VIII

“…There are few reports of spontaneous arterial (and more specifically coronary) thrombosis [5,6]. There has been a single report of acute coronary arterial occlusion occurring during infusion of recombinant Factor VIII in a patient with haemophilia [7]. Whether the infusion raised the Factor VIII levels to the super-normal levels observed in this case is uncertain, but the thrombosis may have been related to a sudden change in Factor VIII levels.…”