Prevalence and risk factors for heart disease among males with hemophilia

Kulkarni, Roshni; Soucie, J. Michael; Evatt, Bruce L.

doi:10.1002/ajh.20339

Cited by 116 publications

(140 citation statements)

References 21 publications

(22 reference statements)

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“…The frequency of cardiovascular incidents and mortality related to coronary artery disease is lower in patients with haemophilia in comparison to the general population [2,3]. It was demonstrated that reduction of mortality is not related to lower prevalence of typical cardiovascular risk factors [4].…”

Section: Discussionmentioning

confidence: 92%

“…After the introduction of treatment with factor VIII substitutes the number of deaths caused by bleeding related to haemophilia dropped and the mean survival time of the patients increased [2]. Aging of the population of patients with haemophilia caused an increase in the frequency of age-related diseases including coronary disease [3]. Below, we describe a case of a patient with moderate haemophilia A and anterior wall myocardial infarction.…”

Section: Introductionmentioning

confidence: 99%

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Myocardial infarction in a patient with moderate haemophilia A

Czubak¹,

Serwicka²,

Dziekoński³

et al. 2011

pwki

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A b s t r a c tWe report a case of patient with a moderate haemophilia A and myocardial infarction. The patient underwent a successful coronary angioplasty preceded by factor VIII administration, nevertheless the double antiplatelet therapy was complicated by gastrointestinal bleeding, which occurred after the discharge. Additionally, the article discusses the treatment strategies of acute coronary syndrome in patients with haemophilia.

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Section: Discussionmentioning

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Myocardial infarction in a patient with moderate haemophilia A

Czubak¹,

Serwicka²,

Dziekoński³

et al. 2011

pwki

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“…In the Eastern Province the sickle hemoglobin (HbS) gene is usually on the autochthonous Arab Indian (AI) b-globin gene (HBB) haplotype [1]. The higher fetal hemoglobin (HbF) level in the AI haplotype is often associated with milder disease compared with other HbS-associated haplotypes, especially in children [2,3].…”

Section: Author Contributionsmentioning

confidence: 99%

Clotting factor concentrate use and occurrence of thrombotic events in patients with hemophilia: A nationwide and 15‐year cohort study

et al. 2016

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“…5,6,37,38 Several European studies have documented a 38% to 80% decreased mortality from ischemic heart disease in males with hemophilia compared with the non-hemophilia male population. 5,6,38 One US study, however, reported an increased mortality for acute myocardial infarction in hemophilia patients compared with the general US male population.…”

Section: Cardiovascular Diseasementioning

confidence: 99%

The Aging Patient with Hemophilia: Complications, Comorbidities, and Management Issues

Philipp

2010

Hematology

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Improvements in hemophilia care and antiviral treatments have resulted in increases in median life expectancy for persons with congenital hemophilia A and B. Currently, 2% of hemophilia A and B patients surveyed in US comprehensive hemophilia treatment centers are 65 years of age or older and 15% are 45 years or older. Many of the complications of hemophilia, including intracranial hemorrhage, joint disease, and inhibitor development, increase with increasing age. Hepatocellular carcinoma and end-stage liver disease are increasing in the older hemophilia population due to infection with hepatitis C (HCV) and HCV/HIV coinfection. Older hemophilia patients also now face the same medical conditions associated with aging in the general population, including cardiovascular disease and cancer. Complex hemostatic management, sometimes in conjunction with antithrombotic management, with extensive cross-specialty clinical and laboratory coordination may be required for the care of the older hemophilia patient. Because elderly hemophilia patients currently represent a small portion of the overall hemophilia population, there is little in the way of clinical data to guide recommendations. Registry databases and cooperative group studies are needed for the development of evidence-based guidelines for the older hemophilia population, which is anticipated to expand in the future.

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Prevalence and risk factors for heart disease among males with hemophilia

Cited by 116 publications

References 21 publications

Myocardial infarction in a patient with moderate haemophilia A

Myocardial infarction in a patient with moderate haemophilia A

Clotting factor concentrate use and occurrence of thrombotic events in patients with hemophilia: A nationwide and 15‐year cohort study

The Aging Patient with Hemophilia: Complications, Comorbidities, and Management Issues

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