Acute kidney injury in the intensive care unit: An update and primer for the intensivist

Dennen, Paula; Douglas, Ivor S.; Anderson, Robert J.

doi:10.1097/ccm.0b013e3181bfb0b5

Cited by 180 publications

(121 citation statements)

References 234 publications

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“…10 The main reason behind the high mortality is the development of the ensuing distant organ injury that can lead ultimately to MODS or multiple organ failure (MOF). 11 Consequently, MODS caused by ARF have been a subject of many clinical and experimental studies.…”

Section: Discussionmentioning

confidence: 99%

The mechanism of myocardium and pancreas injury in rabbits with acute renal failure might be related to myeloperoxidase and membrane pump activities

et al. 2010

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LABORATORY STUDYThe mechanism of myocardium and pancreas injury in rabbits with acute renal failure might be related to myeloperoxidase and membrane pump activitiesThe mechanism of myocardium and pancreas injury in acute renal failure Zi-Gang Zhao, Chun-Yu Niu, Yu-Ping Zhang, Rui Han, Ya-Li Hou, Bao-liang Li, and Shu-ting Du Institute of Microcirculation, Hebei North University, Zhangjiakou 075000, Hebei, PR China AbstractThere is increasing evidence indicating that the distant organ injury is a major contributor of high mortality in patients subjected to acute renal failure (ARF). However, sources and mechanisms that ARF causes distant organ injury remain to be determined. The aim of this study is to explore the mechanism from polymorphonuclear neutrophil (PMN) sequestration and membrane pump suppression. To achieve this, we examined myeloperoxidase (MPO), a marker of PMN accumulation in tissues, and membrane pump activities of heart, pancreas, and kidney in two ARF rabbit models. Rabbits are randomly assigned to control, HgCl 2 -treated, and glycerin-treated groups. ARF animal models are established by hypodermic injection of 1% HgCl 2 with 1.3 mL/kg bodyweight (bw) in HgCl 2 -treated group or intramuscular injection of 50% glycerin with 10 mL/kg bw in glycerin-treated group, respectively, and all animals in each group are further divided into 12 h, 24 h, and 48 h subgroups with each consisting of six rabbits. Six healthy rabbits serve as control group. Results have shown that MPO activities of kidney, myocardium, and pancreas in two model groups were significantly increased than control group at diverse time points. Membrane pump activities of kidney in two model groups are significantly lower than the control group at multiple time points. Moreover, Na -ATPase activities of myocardium and pancreas in two model groups are gradually declined with the development of ARF. These findings suggest that PMN sequestration and membrane pump suppression plays an important role in the pathogenesis of ARF and also a major mechanism of myocardium and pancreas injury during the process of ARF.

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Section: Discussionmentioning

confidence: 99%

The mechanism of myocardium and pancreas injury in rabbits with acute renal failure might be related to myeloperoxidase and membrane pump activities

et al. 2010

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“…40, Nº 1, enero-abril introducción La insuficiencia renal aguda (IRA) es una complicación frecuente en las unidades de cuidados intensivos (UCI). Su incidencia ha aumentado en los últimos años y se asocia con un incremento de mortalidad y morbilidad 1 . La IRA se desarrolla entre un 5 y 25% de pacientes críticos según las series; de éstos, aproximadamente un 6% requirieren terapia de depuración extrarrenal (TDE) 2,3 .…”

Section: Departamento De Anestesia Y Cuidados Intensivosunclassified

Circuit life span of continuous renal replacement therapy in critically ill patients with or without conventional anticoa-gulation: an observational prospective study

Sanz

Hidalgo

García-Fernández

2017

An Sist Sanit Navar

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“…7 Hypoxia is also an acknowledged pathway to renal injury and ischemiareperfusion, which is an inevitable event accompanying renal transplantation and is considered a common cause for delayed graft function and acute renal failure. [8][9][10][11] Understanding the mechanisms involved in hypoxic pathophysiology is of great importance for the prevention and treatment of hypoxic renal injury, especially for improving renal allograft outcome in the recipient after kidney transplantation. 12 Hypoxia can activate a large range of signaling networks and regulate the expression of a variety of growth factors, cytokines, and signaling molecules in a cell-and tissue-specific manner.…”

Section: Introductionmentioning

confidence: 99%

ERK and p38 upregulation versus Bcl-6 downregulation in rat kidney epithelial cells exposed to prolonged hypoxia

Luo

Shi

et al. 2017

cell transplant

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Hypoxia is a common cause of kidney injury and a major issue in kidney transplantation. Mitogen-activated protein kinases (MAPKs) are involved in the cellular response to hypoxia, but the precise roles of MAPKs in renal cell reactions to hypoxic stress are not well known yet. This work was conducted to investigate the regulation of extracellular signal-regulated kinase-1 and -2 (ERK1/2) and p38 and their signaling-relevant molecules in kidney epithelial cells exposed to prolonged hypoxia. Rat kidney epithelial cells Normal Rat Kidney (NRK)-52E were exposed to hypoxic conditions (1% O 2 ) for 24 to 72 h. Cell morphology was examined by light microscopy, and cell viability was checked by 3-The expression of ERK1/2 and p38 MAPK, as well as their signaling-related molecules, was measured by Western blot and real-time polymerase chain (RT-PCR) reaction. At the 1% oxygen level, cell morphology had no appreciable changes compared to the control up to 72 h of exposure under light microscopy, whereas the results of MTS showed a slight but significant reduction in cell viability after 72 h of hypoxia. On the other hand, ERK1/2 and p38 phosphorylation remarkably increased in these cells after 24 to 72 h of hypoxia. In sharp contrast, the expression of transcription factor B-cell lymphoma 6 (Bcl-6) was significantly downregulated in response to hypoxic stress. Other intracellular molecules relevant to the ERK1/2 and p38 signaling pathway, such as protein kinase A, protein kinase C, Bcl-2, nuclear factor erythroid 2-related factor 2, tristetraprolin, and interleukin-10(IL-10), had no significant alterations after 24 to 72 h of hypoxic exposure. We conclude that hypoxic stress increases the phosphorylation of both ERK1/2 and p38 but decreases the level of Bcl-6 in rat kidney epithelial cells.

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Acute kidney injury in the intensive care unit: An update and primer for the intensivist

Cited by 180 publications

References 234 publications

The mechanism of myocardium and pancreas injury in rabbits with acute renal failure might be related to myeloperoxidase and membrane pump activities

The mechanism of myocardium and pancreas injury in rabbits with acute renal failure might be related to myeloperoxidase and membrane pump activities

Circuit life span of continuous renal replacement therapy in critically ill patients with or without conventional anticoa-gulation: an observational prospective study

ERK and p38 upregulation versus Bcl-6 downregulation in rat kidney epithelial cells exposed to prolonged hypoxia

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