Acute kidney injury due to excessive and prolonged intramuscular injection of veterinary supplements containing vitamins A, D and E: A series of 16 cases

Daher, Elizabeth De Francesco; Martiniano, Lorena Vasconcelos Mesquita; Lima, Laio Ladislau Lopes; Filho, Newton Carlos Viana Leite; Souza, Louize Emanuele de Oliveira; Fernandes, Paulo Henrique Palácio Duarte; Silva, Sônia Leite da; Silva, Geraldo Bezerra da

doi:10.1016/j.nefro.2016.05.017

Cited by 23 publications

(26 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…While hypercalcaemia has been known to cause AKI for many decades in a variety of presentations such as malignancies, sarcoidosis, milk alkali syndrome, vitamin D overdose, hyperparathyroidism and hyperthyroidism, [26][27][28][29][30] the estimated risk of AKI following hypercalcaemia was unclear. Our study demonstrated that elevated calcium levels on admission were associated with a 1.51-fold increased risk of in-hospital AKI.…”

Section: Discussionmentioning

confidence: 99%

Admission calcium levels and risk of acute kidney injury in hospitalised patients

et al. 2018

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Admission calcium levels and risk of acute kidney injury in hospitalised patients

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Kidney disease has been reported among AAS users, but only in individuals with significant kidney damage (3,8). The discovery of novel biomarkers has a great importance for early detection of kidney disease and allows the adoption of measures to prevent or slow kidney disease progression.…”

Section: Discussionmentioning

confidence: 99%

“…Renal function abnormalities are described among AAS users, usually when supra-physiologic doses are used, including the use of veterinary supplements (3,8). One of the mechanisms that have been proposed for kidney injury in these cases is the excess use of vitamin D, leading to hypercalcemia, hypercalciuria and nephrocalcinosis (8,20).…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

“…The use of anabolic-androgenic steroids (AAS) among physical activity practitioners has increased in the last years, and it is associated with body image disorders and clinical complications, including kidney disease (1)(2)(3). In Brazil, the estimated prevalence of AAS use among recreational physical activity practitioners varies from 2.1% to 31.6% (4).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Novel Kidney Injury Biomarkers Among Anabolic Androgenic Steroids Users - Evidence of Subclinical Kidney Disease

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…compounds is practiced in South America and the Middle East with an apparently high frequency of end-stage renal disease (ESRD) [2,3,4].…”

mentioning

confidence: 99%

Effects of Bodybuilding Supplements on the Kidney: A Population-Based Incidence Study of Biopsy Pathology and Clinical Characteristics among Middle Eastern Men

Ali

Almukhtar

Sharif

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: The incidence of kidney diseases among bodybuilders is unknown. Methods: Between January 2011 and December 2019, the Iraqi Kurdistan 15 to 39 year old male population averaged 1,100,000 with approximately 56,000 total participants and 25,000 regular participants (those training more than one year). Annual age specific incidence rates (ASIR) with (95% confidence intervals) per 100,000 bodybuilders were compared with the general age-matched male population. Results: Fifteen male participants had kidney biopsies. Among regular participants, diagnoses were: focal segmental glomerulosclerosis (FSGS), 2; membranous glomerulonephritis (MGN), 2; post-infectious glomeruonephritis (PIGN), 1; tubulointerstitial nephritis (TIN), 1; and nephrocalcinosis , 2. Acute tubular necrosis (ATN) was diagnosed in 5 regular participants and 2 participants training less than one year. Among regular participants, anabolic steroid use was self-reported in 26% and veterinary grade vitamin D injections in 2.6%. ASIR for FSGS, MGN, PIGN, and TIN among regular participants was not statistically different than the general population. ASIR of FSGS adjusted for anabolic steroid use was 3.4 (-1.3 to 8.1), a rate overlapping with FSGS in the general population at 2.0 (1.2 to 2.8). ATN presented as exertional muscle injury with myoglobinuria among new participants. Nevertheless, ASIR for ATN among total participants at 1.4 (0.4 to 2.4) was not significantly different than for the general population at 0.3 (0.1 to 0.5). Nephrocalcinosis was only diagnosed among bodybuilders at a 9-year cumulative rate of one per 314 vitamin D injectors. Conclusions: Kidney disease rates among bodybuilders were not significantly different than for the general population, except for nephrocalcinosis that was caused by injections of veterinary grade vitamin D compounds.

show abstract

Acute kidney injury due to excessive and prolonged intramuscular injection of veterinary supplements containing vitamins A, D and E: A series of 16 cases

Abstract: Excessive use of veterinary vitamin supplements containing high doses of vitamin A, D and E was associated with AKI. Hypercalcaemia, which was a common finding, appears to be a contributing factor to the development of this type of AKI.

Cited by 23 publications

References 27 publications

Admission calcium levels and risk of acute kidney injury in hospitalised patients

Admission calcium levels and risk of acute kidney injury in hospitalised patients

Novel Kidney Injury Biomarkers Among Anabolic Androgenic Steroids Users - Evidence of Subclinical Kidney Disease

Effects of Bodybuilding Supplements on the Kidney: A Population-Based Incidence Study of Biopsy Pathology and Clinical Characteristics among Middle Eastern Men

Contact Info

Product

Resources

About