Novel Kidney Injury Biomarkers Among Anabolic Androgenic Steroids Users - Evidence of Subclinical Kidney Disease

Daher, Elizabeth De Francesco; Fernandes, Paulo Henrique Palácio Duarte; Meneses, Gdayllon Cavalcante; Bezerra, Gabriela Freire; Ferreira, Leonardo de Souza Lima; Viana, Glautemberg de Almeida; Martins, Alice Maria Costa; Silva, Geraldo Bezerra da

doi:10.5812/asjsm.65540

Cited by 5 publications

(2 citation statements)

References 20 publications

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“…It was reported that animals treated with nandrolone revealed disruption in redox homeostasis in various organs such as the liver, heart and kidneys (Daher et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Biochemical and Histopathological Aspects of Nandrolone Decanoate Nephrotoxicity and Potential Impact of Alpha Lipoic Acid

Mahmoud

Halloull

2023

The Egyptian Journal of Forensic Sciences and Applied Toxicolog

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Background: One of the widely abused anabolic-androgenic steroids worldwide is nandrolone decanoate (ND). Objectives: This work aimed to study whether alpha lipoic acid (ALA) treatment could modulate ND-induced renal dysfunction. Materials & methods: forty adult albino rats were divided into four groups. 1st group served as negative control; 2nd group received ALA (100 mg/kg orally by gastric gavage daily); 3rd group received ND in 28 mg/kg BW intra-peritoneal injection once weekly; 4th group received the dose of ND along with ALA (in the previous doses); all for eight weeks. Results: administration of nandrolone decanoate induced significant increase in serum urea and creatinine. Significant increase in lipid peroxidation malondialdehyde (MDA) and pro-inflammatory cytokines (TNFα) together with significant reduction of the antioxidant Glutathione peroxidase (GPx) activities and the anti-inflammatory interleukin (IL-4) in kidney tissues were also recorded. Histopathological evidence of renal tissue injury was detected. Co-administration of ALA along with ND ameliorated the effects mentioned above. Conclusion: According to this study, the administration of ALA can provide a protective role, through its anti-inflammatory and antioxidant effects, against ND-induced renal toxicity.

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“…It was reported that animals treated with nandrolone revealed disruption in redox homeostasis in various organs such as the liver, heart and kidneys (Daher et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Biochemical and Histopathological Aspects of Nandrolone Decanoate Nephrotoxicity and Potential Impact of Alpha Lipoic Acid

Mahmoud

Halloull

2023

The Egyptian Journal of Forensic Sciences and Applied Toxicolog

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“…It has been documented that AASs have different types of adverse effects, such as acute kidney injury, chronic kidney diseases, glomerular toxicity, etc., in kidneys (5). One of the adverse effects of AAS misuse is renal failure in bodybuilders and athletes (6,7). It has been reported that an increase in athletes' serum creatinine levels may be due to AAS abuse.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Pten and Pi3k/Akt Expressions in Stanozolol-Treated Rat Kidneys

Kotil¹,

Sevim²,

Kara³

2022

jmed

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Objective: Stanozolol is an anabolic androgenic steroid (AAS) that is widely used by teenagers and athletes in bodybuilding, sports, and athletics. The potential effects of stanozolol in kidney functions have not been defined. In this study we investigated the expression of tumor suppressor protein phosphatase and tensin homolog (Pten) and mRNA levels of phosphatidylinositol 4,5-bisphosphate 3 kinase (Pi3k) and the protein kinase B (Akt1) signaling pathway in rat kidneys treated by stanozolol. Material and Method: Rats were randomized to 5 groups as control, solvent control, steroid (stanozolol), solvent-exercise, and steroid-exercise. Subcutaneous injection of stanozolol (5 mg/kg) was applied for 28 days and swimming exercise was performed 20 min/day, 5 days/week in exercise groups. Expression of PTEN was evaluated by immunohistochemistry. Also, Pten, Pi3k, and Akt1 mRNA expressions were analyzed via RT-PCR.

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Impact of anabolic steroid consumption on biochemical and hematological parameters in bodybuilders: A systematic review and evidence gap mapping

Tavares,

Vital,

Cunha

et al. 2024

Performance Enhancement & Health

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Novel Kidney Injury Biomarkers Among Anabolic Androgenic Steroids Users - Evidence of Subclinical Kidney Disease

Abstract: Background: Kidney injury associated with the use of anabolic androgenic steroids (AAS) has been described. The aim of the study was to investigate new kidney injury biomarkers among bodybuilders using anabolic androgenic steroids (AAS).

Cited by 5 publications

References 20 publications

Biochemical and Histopathological Aspects of Nandrolone Decanoate Nephrotoxicity and Potential Impact of Alpha Lipoic Acid

Biochemical and Histopathological Aspects of Nandrolone Decanoate Nephrotoxicity and Potential Impact of Alpha Lipoic Acid

Evaluation of Pten and Pi3k/Akt Expressions in Stanozolol-Treated Rat Kidneys

Impact of anabolic steroid consumption on biochemical and hematological parameters in bodybuilders: A systematic review and evidence gap mapping

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