Acute kidney injury and outcome following aortic valve replacement for aortic stenosis

Abstract

More than 1 in 5 patients (22.5%) who underwent AVR developed AKI postoperatively. AKI was associated with higher morbidity and was an independent predictor of operative mortality. However, AKI was not a determinant of long-term survival.

Implications of obesity in cardiac surgery: pattern of referral, physiopathology, complications, prognosis

“…Exogenous and endogenous toxins, metabolic factors, ischemia and reperfusion, neurohormonal activation, inflammation and oxidative stress: though acting at different times and with different intensity synergistically induce renal perioperative damage (17). Several studies have disclosed a significant association between obesity and CSA-AKI following both CABG and valvular surgery (18). At least three different pathways may explain such an association.…”

Acute kidney injury post–transcatheter aortic valve replacement

“…AKI following TAVR is independently associated with a 5‐ to 8‐fold increase in 30‐day mortality and a > 3‐fold increase in 1‐year mortality . Although few studies have looked at AKI following SAVR specifically, 30‐day mortality for patients with AKI following other cardiac surgery (most commonly coronary artery bypass grafting) has ranged from 6% to 45%, compared with 1% to 3% for patients without AKI . This wide range can be largely attributed to the lack of a standard definition for AKI.…”

“…4,5,[9][10][11] Although few studies have looked at AKI following SAVR specifically, 12,13 30-day mortality for patients with AKI following other cardiac surgery (most commonly coronary artery bypass grafting) has ranged from 6% to 45%, compared with 1% to 3% for patients without AKI. [10][11][12][13][14] This wide range can be largely attributed to the lack of a standard definition for AKI.…”

Renal recovery and long‐term survival following acute kidney injury after coronary artery surgery: a nationwide study

“…23,24 The reasons for this relationship are believed to be complex but the pro-inflammatory effect of transfusions and promotion of oxidative stress have been suggested. However, in line with numerous other studies, we found a significant relationship between the number of units RBC transfused and risk of AKI.…”

“…However, in line with numerous other studies, we found a significant relationship between the number of units RBC transfused and risk of AKI. 23,24 The reasons for this relationship are believed to be complex but the pro-inflammatory effect of transfusions and promotion of oxidative stress have been suggested. 25,26 Although the observational nature of our study precludes the determination of a causal relationship these findings might suggest that CABG patients' kidney function could benefit from a more restrictive blood transfusion strategy.…”