Acute kidney injury among ST elevation myocardial infarction patients treated by primary percutaneous coronary intervention: a multifactorial entity

Shacham, Yacov; Steinvil, Arie; Arbel, Yaron

doi:10.1007/s40620-015-0255-4

Cited by 68 publications

(77 citation statements)

References 64 publications

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“…In addition, the AUROC for both of these scores to predict CIN when applied to patients with STEMI was 0.57 [14] which is much lower than the performance of our score. Most importantly, AKI in the setting of myocardial infarction is multifactorial and should not be assumed to be solely a contrast-induced nephropathy, as demonstrated by Shacham et al [5,6]. Therefore, the use of these scores cannot be extended to predict AKI in AMI patients.…”

Section: Discussionmentioning

confidence: 99%

“…AKI in the setting of AMI is a multifactorial entity [5]. Beyond the widely recognized negative impact of contrast volume, the key mechanisms in AKI pathogenesis include systemic and renal hemodynamic changes secondary to impaired cardiac output, arrhythmias, and increased venous congestion [1,6].…”

Section: Introductionmentioning

confidence: 99%

“…Changes in volume status, medications, atheroembolism during percutaneous coronary intervention (PCI) or intra-aortic balloon pump counter-pulsation, and bleeding are all common conditions in patients with AMI that may contribute to the development of AKI [1]. In addition, various inflammatory and metabolic markers are implicated in the pathogenesis of AKI in patients with AMI [5].…”

Section: Introductionmentioning

confidence: 99%

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Development of a novel score to predict the risk of acute kidney injury in patient with acute myocardial infarction

et al. 2016

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Development of a novel score to predict the risk of acute kidney injury in patient with acute myocardial infarction

et al. 2016

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“…In this group, AKI is associated with contrast volume, hemodynamic impairment, inflammation, bleeding, and nephrotoxic agents [1, 3, 4]. However, the incidence of AKI reported varies considerably with the population evaluated and the definitions used [1, 6].…”

Section: Introductionmentioning

confidence: 99%

Impact of KDIGO-Defined Acute Kidney Injury on Mortality after Percutaneous Coronary Intervention for Acute Myocardial Infarction

et al. 2018

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Background: There are limited data regarding the incidence and long-term impact of acute kidney injury (AKI) according to the KDIGO guidelines on the outcome in patients with myocardial infarction (MI) treated with percutaneous coronary intervention (PCI). The aim of the study was to evaluate the prevalence of AKI, as classified by the KDIGO criteria, and its association with long-term mortality. Methods: Data from 5,859 MI patients undergoing PCI at our institution were analyzed. We compared the group without and with AKI according to the KDIGO criteria in relation to long-term mortality. Results: AKI was documented in 499 (8.5%) patients. AKI stage 1 occurred in 6.2% of patients, AKI stage 2 in 0.9% of patients, and AKI stage 3 in 1.5% of patients. Patients with AKI had a higher long-term mortality (57.3 vs. 20.6%; p < 0.0001). The mortality was 50.3% in AKI stage 1, 56.9% in AKI stage 2, and 87.2% in AKI stage 3. The hazard ratios for all-cause mortality for AKI stages 1–3 were 1.77, 1.85, and 6.30 compared to patients with no AKI. Cardiogenic shock, bleeding, heart failure, age, renal dysfunction, diabetes, hyperlipidemia, ST-elevation MI, contrast volume/glomerular filtration ratio, P2Y12 receptor antagonists, and radial access were associated with the development of AKI. Conclusion: A slight increase in serum creatinine was associated with a progressive increase in long-term mortality in patients with AKI according to the KDIGO definition.

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“…Marenzi et al found that lower LVEF is associated with CIN 36. Cowburn et al found that patients developing CRP were independent risk factors for CIN [38][39][40]. Moreover, in the Mehran score, diabetes mellitus, congestive heart failure, CM volume, age >75 years, and IABP usage are recognized as risk factors for mortality 41.…”

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confidence: 99%

Perkütan Koroner Girişim Yapılan Koroner Yavaş Akım Olgularında, Serum Urotensin II Düzeyi ve Kontrast Kaynaklı Nefropati Gelişimi ile Bir Yıllık Klinik Takip Bulguları Arasındaki İlişki

Huyut¹

2019

Sakarya Medical Journal

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Objective Coronary slow-reflow phenomenon (CSFP) and Contrast-Induced Nephropathy (CIN) are associated with an increased risk of major cardiovascular adverse events. This study aimed to evaluate the relationship between serum Urotensin II molecule (U-II) levels and CIN in patients with CSFP undergoing percutaneous coronary intervention (PCI). ( Sakarya Med J 2019, 9(3):442-454 ). Materials and MethodsWe enrolled 227 patients (161 male and 66 female; mean age: 61,44 ± 12,44 years) with angiographically diagnosed CSFP. The patients were divided into two groups according to CIN development (Non-CIN (n=206) and CIN group (n=21)).Results CIN was observed in 9,25%(n=21) of the CSFP patients. Serum U-II level was significantly higher in CIN group than in non-CIN group (6,79±2,20 vs. 3,00±1,29, p<0,001).One year clinical follow-up findings including all-cause mortality (7(33,30%) vs. 24(11,70%), p=0,013), cardiovascular death(7(33,30%) vs. 18(8,70%), p=0,003) and Major Adverse cardiovascular events (MACE) (10(47,60%) vs. 46(22,40%), p=0,011) were significantly higher in CIN group. We also performed forward conditional logistic regression analysis and found that U-II (Odds ratio (OR)=3,983; 95% confidence interval (CI): 2,25 to 7,052; p <0,001) and Mehran score (OR=1,228, 95% CI: 1,083-1,393, p=0,001) were independently predicted CIN development, in patients with CSFP.Conclusion Baseline serum U-II concentrations and higher Mehran scores are independently associated with CIN in CSFP patients. One-year clinical follow-up findings including all-cause mortality, cardiovascular death and MACE were significantly higher in CIN group, but stroke and myocardial infarction rates were similar in both groups. ÖzAmaç Koroner yavaş akım fenomeni (CSFP) ve kontrast kaynaklı nefropati (CIN), artmış major advers kardiyovasküler olay ile ilişkilidir. Bu çalışmada, CSFP'li perkütan koroner girişim (PCI) yapılan hastalarda, serum ürotensin II (U-II) düzeyi ile CIN arasındaki ilişkiyi değerlendirmeyi amaçladık. ( Sakarya Tıp Dergisi 2019, 9(3):442-454 ) Gereç ve YöntemlerAnjiyografik olarak CSFP tanısı almış 227 hasta (161 erkek, 66 kadın; ortalama yaş 61,44±12,44) çalışmaya alındı. Hastalar CIN gelişmesine (CIN olmayan (n = 206) ve CIN grubu (n = 21)) göre iki gruba ayrıldı.Bulgular CSFP hastalarının %9,25'inde (n=21) CIN gözlendi. Serum U-II düzeyi, CIN grubunda CIN olmayan gruba göre anlamlı derecede yüksek saptandı (6,79±2,20 vs. 3,00±1,29, p<0,001). Tüm nedenlere bağlı mortalite (7(%33,30) vs. 24(%11,70), p=0,013), kardiyovasküler ölüm (7(%33,30) vs. 18(%8,70), p=0,003) ve major advers kardiyovasküler olay (MACE) (10(%47,60) vs. 46(%22,40), p=0,011) CIN grubunda anlamlı derecede yüksek saptandı. Ayrıca çalışmamızda ileri koşullu lojistik regresyon analizi yapıldı ve CSFP'li hastalarda CIN gelişimininin bağımsız öngördürücülerinin, yüksek serum U-II konsantrasyonları (Odss oranı(OR)=3,983; %95 güven aralığı(CI):2,25-7,052; p<0,001) ve yüksek Mehran skoru (OR=1,228, %95 CI: 1,083-1,393, p=0,001) olduğu saptandı. Sonuç Yaptığımız çalışma...

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Acute kidney injury among ST elevation myocardial infarction patients treated by primary percutaneous coronary intervention: a multifactorial entity

Cited by 68 publications

References 64 publications

Development of a novel score to predict the risk of acute kidney injury in patient with acute myocardial infarction

Development of a novel score to predict the risk of acute kidney injury in patient with acute myocardial infarction

Impact of KDIGO-Defined Acute Kidney Injury on Mortality after Percutaneous Coronary Intervention for Acute Myocardial Infarction

Perkütan Koroner Girişim Yapılan Koroner Yavaş Akım Olgularında, Serum Urotensin II Düzeyi ve Kontrast Kaynaklı Nefropati Gelişimi ile Bir Yıllık Klinik Takip Bulguları Arasındaki İlişki

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