Acute intracranial hypertension increases gastric tonus in anesthetized rats

Cristino-Filho, Gerardo; Leal, Paulo Roberto Lacerda; Lira, Gislano Heverton Soares de; Souza, Stelme Girão de; Rola, Francisco H.; Oliveira, Ricardo Brandt de; Souza, Miguel Angelo N.; Santos, Armênio Aguiar dos

doi:10.1016/j.autneu.2008.12.007

Cited by 2 publications

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Steroid hormones, in particular progesterone and estrogen, have effects on the gastric motility and secretions [19], and are also involved in the pathogenesis of some functional disorders in the gut [20]. This might provide a sensible explanation for the clinically observed gender difference in the prevalence of duodenal ulcer (Table 1 [ [48][49][50][51][52][53][54][55][56][57][58][59][60][61][62]). …”

Section: Tbi Gi Tract and Sex Hormonesmentioning

confidence: 99%

Traumatic Brain Injury and the Gastrointestinal Tract: The Role of Female Sexual Hormones

et al. 2017

View full text Add to dashboard Cite

Traumatic brain injury (TBI) is an important public health problem which can lead to several complications like gastrointestinal dysfunction. Patients with TBI often suffer from gastrointestinal dysfunctions such as enteral feeding intolerance. Gastric ulceration is induced by various forms of stress like surgery, ischemia and trauma. TBI causes a delayed but significant decrease in intestinal contractile activity in the ileum leading to delayed transport. The association between severity of brain injury and enteral feeding intolerance suggests a strong link between the central nervous system and the non-functional gut. The results of recent basic and clinical studies revealed the beneficial effects of estrogen and progesterone hormones in the treatment of gastrointestinal dysfunction. Females have more resistance to stress and fewer gastrointestinal lesions occur in females as compared to males. Sex steroid hormones have sparked interest as possible neuroprotective agents after traumatic injury and many studies have been done on this subject. This article reviews the literature related to some possible physiological effects of female sexual hormones on the gastrointestinal tract following TBI.

show abstract

Section: Tbi Gi Tract and Sex Hormonesmentioning

confidence: 99%

Traumatic Brain Injury and the Gastrointestinal Tract: The Role of Female Sexual Hormones

et al. 2017

View full text Add to dashboard Cite

show abstract

Lesões cerebrais agudas e sua influência sobre a motilidade gastrintestinal

Lucena¹,

Tibúrcio²,

Vasconcelos³

et al. 2011

Rev. bras. ter. intensiva

View full text Add to dashboard Cite

REVIEW ARTICLEmeans of food administration to brain injury patients as tool to reduce gastrointestinal symptoms. Of note, food intolerance may be associated with increased morbidity and increased hospital stay costs. (2,3) Considering the paucity of both national and international studies correlating SAH, ICH and gastric emptying (GE), the main objective of this paper is to compare and discuss physiological and pathophysiological related to SAH, ICH and gut motility. METHODSA literature search was conducted to analyze the pattern of gut motility following acute brain injury with ICH. Articles discussing possible therapeutic approaches for ICH-related gut complications were also evaluated. The literature search included national and international health sciences journals, and we searched for articles related to the brain-gastrointestinal tract functional axis and its behavior either in experimental animal models of brain injury or acute brain injury patients. Using the inclusion criteria, a web based search was conducted on the following electronic libraries: Scientific Electronic Library Online (Scielo) © , Periódicos/Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) © , PubMed/Medline© and Google Scholar Beta © .Twenty-five articles published between 1982 and 2010 were selected. Of those, eleven focused on the influence of ICH on gut motility (GM), ten discussed means of nutrition of administration in moderate to severe head trauma (HT) (Glasgow coma scale < 8), and finally, four articles discussed the main metabolic changes in head trauma subjects, with an emphasis on nutritional support. Influence of intracranial hypertension on gut motilityEleven articles about ICH influence about gut motility were analyzed. Five (45.4%) were related to gastric and intestinal emptying, four (36.3%) focused on pressure changes throughout the gastrointestinal tract (GIT) (two studied the amplitude and frequency of food propellant contractions, and the other two analyzed the inferior esophageal sphincter behavior under ICH conditions), and two (18.1%) studies evaluated GIT electrical activity, studying the migratory myoelectric complex by means of body surface electrodes or electrogastrogram. Of all of the articles, two (18.8%) reported that HIC variation is directly proportional to gastric contraction intensity, based on a GE analysis of the amplitude and frequency of contractions in anesthetized rats with intra-cerebral cannulation-induced ICH. The remaining nine (81.8%) articles found that increased ICP is related to slower GIT transit, and this food bolus transit delay is associated with intolerance to enteral nutrition. Pharmacological intervention to accelerate the GIT was evaluated in one of the analyzed articles. Another study was designed to evaluate the association between ICP changes in thirty-seven intracranial tumor patients who performed Valsalva's maneuver during evacuation. All patients performed the maneuver, independent of constipation, and no increased ICP decompensation was observed. Additi...

show abstract

Acute intracranial hypertension increases gastric tonus in anesthetized rats

Cited by 2 publications

References 25 publications

Traumatic Brain Injury and the Gastrointestinal Tract: The Role of Female Sexual Hormones

Traumatic Brain Injury and the Gastrointestinal Tract: The Role of Female Sexual Hormones

Lesões cerebrais agudas e sua influência sobre a motilidade gastrintestinal

Contact Info

Product

Resources

About