Acute intensive interval training and T-lymphocyte function

Fry, Rod W.; Morton, Alan R.; Keast, David

doi:10.1249/00005768-199203000-00010

Cited by 33 publications

(35 citation statements)

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“…Con¯icting results have been reported with regard to exercise and the PHA-stimulated proliferative response (Nielsen and Pedersen 1997). In some studies it has been found that the proliferative response decreased during running and cycling at (Fry et al 1992;Tvede et al 1989Tvede et al , 1994, whereas studies including cycling at intensities of 75% of O 2 max and repeated periods of maximal exercise have not shown any changes Nielsen et al 1996a).…”

Section: Discussionmentioning

confidence: 99%

Competitive sustained exercise in humans, lymphokine activated killer cell activity, and glutamine ? an intervention study

Rohde

Asp

MacLean

et al. 1998

European Journal of Applied Physiology

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This study examined whether oral glutamine supplementation abolishes some of the exercise-induced changes in lymphocyte functions following long-term intense exercise. A group of 16 marathon runners participating in The Copenhagen Marathon 1996 were placed randomly in either a placebo (n = 7) or a glutamine receiving group (n = 9). Each subject received four doses of either placebo or glutamine (100 mg x kg(-1)) administered at 0, 30, 60, and 90-min post-race. In the placebo group the plasma glutamine concentrations were lower than pre-race values during the post-exercise period [mean 647 (SEM 32) compared to 470 (SEM 22) micromol x 1(-1) 90-min post-race, P < 0.05] whereas glutamine supplementation maintained the plasma glutamine concentration (at approximately 750 micromol x 1(-1)). Glutamine supplementation in vivo had no effect on the lymphokine activated killer (LAK) cell activity, the proliferative responses or the exercise-induced changes in concentrations or percentages of any of the leucocyte subpopulations examined. Glutamine addition in in vitro studies enhanced the proliferative response in both groups. These data would suggest that decreased plasma glutamine concentrations post-exercise are not responsible for exercise-induced decrease in LAK activity and that the influence of glutamine in vitro is not dependent on the plasma glutamine concentration at the time of sampling.

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Section: Discussionmentioning

confidence: 99%

Competitive sustained exercise in humans, lymphokine activated killer cell activity, and glutamine ? an intervention study

Rohde

Asp

MacLean

et al. 1998

European Journal of Applied Physiology

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“…There was a reduction in proliferative lymphocyte response which was shown to be brief and transient. Other research investigating how physical activity effects specific immunological parameters demonstrated that prolonged endurance exercise causes an increase in plasma levels of interleukin-1 (Il-1), possibly as a response to muscle injuries, but plasma interleukin-2 levels were generally reduced [2]. IL-1 secretion may enhance the responsiveness of peripheral blood mononuclear cells, but prostaglandin secretion decreases their IL-2 production.…”

Section: Introductionmentioning

confidence: 99%

End-Stage Renal Disease (ESRD): Physical Activity and Elucidation of Its Effects on Biochemical and Haematological Parameters in Haemodialysis Patients

Muhammad¹

2016

Ann Clin Lab Res

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End-stage renal disease (ESRD) is a progressive disorder for which there is no prospect of recovery, and for which patients receive regular haemodialysis. In ESRD the ability of the kidneys to excrete metabolic waste products and to regulate the composition of extracellular fluid is compromised. Symptoms of ESRD also include cardiovascular dysfunction, anaemia, malnutrition, muscle wasting, muscle weakness, glucose intolerance and reduced bone density. Patients with ESRD are likely to be challenged by participation in exercise whilst undergoing a HD regimen. Nevertheless there is a case for prescribing exercise in patients who struggle to become active. Some benefits of exercise In patients receiving haemodialysis, the benefits of physical exercise, which include: 1) Reduction of toxins and fluid overload in the circulatory system, permitting improved tolerance to the HD regimen and 2) Increased heart rate, which improves cardiovascular performance, 3) a reduction in comorbidities and an increase in well-being, and 4) the facilitation of positive coping strategies. An understanding how exercise can be of clinical advantage in ESRD patients is unique and challenging given the variety of nutritional and clinical conditions with which they present. The haematological and biochemical parameters which should be monitored in these patients (including blood potassium, urea, calcium and hemoglobin levels) need to be prioritized, and this prioritization depends in turn upon general patient well-being. More research is also required in the understanding of physiology and importance of good nutrition in this population. The aim of this work is to provide some background of the key parameters in HD patients and to identify literature on biochemical parameters which are affected during physical activity in HD patients. The results help to emphasize that closer attention should be paid to monitoring HD efficacy and Kt/V, a measure of dialysis adequacy.

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“…Além disso, há mudanças funcionais de linfócitos T, com diminuição da resposta proliferativa a mitógenos no período pós-exercício imediato (FRY et al, 1992). Entre as diversas explicações para este fenômeno, foi sugerida a influência direta do cortisol ou inibição da produção de IL-2 (CUPPS e FAUCI, 1982).…”

Section: ; Quadrilatero E Hoffman-goetz 2005)unclassified

“…O mesmo fato foi observado em modelo experimental, no qual a resposta proliferativa de linfócitos T esplênicos de ratos idosos submetidos a condicionamento físico se comparou a de ratos jovens sedentários (NIEMAN e CANNARELLA, 1994). Por outro lado, atletas engajados em treinamento exaustivo, assim como animais submetidos a modelos de exercícios que levam à exaustão, mostraram supressão da função linfocitária (FRY et al, 1992;MACNEIL et al, 1991;MACKINNON, 1997).…”

Section: Exercício Crônico E Sistema Imunológicounclassified

“…O efeito do exercício sobre a proliferação dos leucócitos é conhecido e varia de acordo com duração, intensidade e o tipo de exercício, como descrito por Fry et al (1992) e demonstrado por outros pesquisadores como Nieman et al (1992), Perdensen e Hoffman-Goetz, (2000); Santos, (2004). Em nosso modelo o exercício foi capaz de restaurar a resposta proliferativa e havendo maior responsividade do grupo DT a IL2 reforça uma resposta imunológica tipo Th 1.…”

Acute intensive interval training and T-lymphocyte function

Cited by 33 publications

References 0 publications

Competitive sustained exercise in humans, lymphokine activated killer cell activity, and glutamine ? an intervention study

Competitive sustained exercise in humans, lymphokine activated killer cell activity, and glutamine ? an intervention study

End-Stage Renal Disease (ESRD): Physical Activity and Elucidation of Its Effects on Biochemical and Haematological Parameters in Haemodialysis Patients

Influência do exercício sobre a resposta imunológica de ratos desnutridos.

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