Acute inhibition of iron absorption by zinc

Olivares, Manuel; Pizarro, Fernando; Gaitán, Diego; Ruz, Manuel

doi:10.1016/j.nutres.2007.04.006

Cited by 19 publications

(6 citation statements)

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“…When the Zn:Fe wt/wt ratio is kept constant we observed that at higher doses of both minerals (11.71 mg of Zn and 10 mg of Fe; Zn:Fe wt/wt ratio 1.17:1) Fe bioavailability was inhibited by 56%, while no inhibitory effect was observed at lower doses (0.59 mg of Zn and 0.5 mg of Fe; Zn:Fe wt/wt ratio 1.2:1) (Olivares et al 2007b). In addition, we have shown that the inhibitory effect of Zn on Fe absorption is of short duration (Olivares et al 2007c). Zn (11.71 mg) inhibited the absorption of 0.5 mg of Fe when both minerals were given simultaneously; however, when Zn was given 30 or 60 min before Fe no inhibitory effect was observed.…”

Section: Effect Of Zn Given In Saline or Aqueous Solutions Or As A Sumentioning

confidence: 87%

Acute inhibition of iron bioavailability by zinc: studies in humans

et al. 2012

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Iron (Fe) and zinc (Zn) deficiencies constitute two of the most important nutritional and public health problems affecting developing countries. Combined supplementation or fortification with Zn and Fe are strategies that can be used to improve the Zn and Fe status of a population. However, there is concern about potential negative interactions between these two micronutrients due to a competitive binding to DMT1 and Zip14 transporter. Studies performed in humans have shown an inhibitory effect of Zn on Fe absorption when both minerals are given together as a solution in fasting conditions. We found that at low doses of iron (0.5 mg) the threshold for the inhibition of iron bioavailability was at a Zn:Fe wt/wt ratio ≥5.9:1, whereas at higher doses of Fe (10 mg) this inhibition occurred at 1:1 Zn:Fe wt/wt ratio. This differential response could be explained by the variation in the abundance of both cations as they compete for a limited number of shared transporters at the enterocyte. Conflicting results have been obtained when this interaction was studied in different food matrices. A negative interaction was not observed when Fe and Zn were provided in a composite hamburger meal, premature formula, human milk, or cow milk. A decrease on Fe absorption was observed in only 1 of 3 studies when Fe and Zn were supplied in wheat flour. The possibility of a negative interaction should be considered for supplementation or fortification programs with both microminerals.

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Section: Effect Of Zn Given In Saline or Aqueous Solutions Or As A Sumentioning

confidence: 87%

Acute inhibition of iron bioavailability by zinc: studies in humans

et al. 2012

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“…Since zinc and iron show some chemical similarity and they do share transport pathways such as the divalent metal transporter 1 (DMT-1) in the intestinal cell, they may therefore be competitive. It was found that zinc administration with an iron aqueous solution lead to acute inhibition of iron bioavailability when both elements are given together in fasting condition [15,16]. It has also been reported that, inhibition of iron absorption Modulation of signaling pathways (PKC, ERK, JAK/STAT, BMP/TGF-β, NFk B,cAMP-CREB, PI3K/Akt, B-cell receptor) Zinc wave; zinc release in cytosol from perinuclear region Zinc spark; zinc ejection from oocyte, which is necessary for the egg-to-embryo Transition * A zinc finger is a small protein structural motif that is characterized by the coordination of one or more zinc ions in order to stabilize the fold.…”

Section: Discussionmentioning

confidence: 99%

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2017

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Iron deficiency anaemia is a major health problem worldwide, but may be complicated in underdeveloped nations by deficiencies of other micronutrients with consequences for adequate treatment. The World Health Organization (WHO) estimates that 2 billion people-over 30% of the world's populationare anaemic, approximately 50% of cases of anaemia are considered to be due to iron deficiency. Aim: Since a combined deficiency of trace elements has great consequences in the approach of this problem, zinc status was assessed in blood of iron deficient anaemic patients in Sudan representing sub-Saharan Africa and compared with Dutch anaemic patients representing Western Europe. Method: Zinc as well as iron were measured with instrumental neutron activation analysis (INAA) in 22 Sudanese anaemic patients and four controls as well as in 17 Dutch anaemic patients and four controls. Result: In the Sudanese patients very low concentrations of zinc were measured, 3 ± 1 mg/L compared to a control group of healthy individuals (5 ± 1 mg/L), while all Dutch patients had normal zinc levels (5 ± 1 mg/L). When matched for haemoglobin level, the Sudanese patients still showed lower zinc concentrations. Even in the Sudanese patients without a known history of malnutrition and in patients with the anaemia of chronic disease zinc levels were significantly lower than in the controls. A positive correlation was observed between Fe and Zn in blood of the Sudanese subjects (r=0.654), while there is no or a very week relation between Fe and Zn in blood of the Dutch group (r=0.08). The low level of Fe and Zn for the Sudanese group might be ascribed to the poor intake of these two nutrients with the main dietary food (cereals) in this area. Conclusion: In iron deficiency anaemia in Sudanese patients, a deficiency of zinc should be taken into account in case of supplementation.

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“…Other minerals may reduce iron absorption as iron ions compete with other divalent ions for the cellular transporter (Ca 2+ and Zn 2+ ) [74]. Zinc showed inhibitor capabilities when administered with iron to healthy volunteers [75]. Thus, it becomes important to account for inorganic ions concentrations when preparing fortified foods.…”

Section: Nutritional Sources That Hinder Iron Absorptionmentioning

confidence: 99%

Iron-Enriched Nutritional Supplements for the 2030 Pharmacy Shelves

et al. 2021

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Iron deficiency (ID) affects people of all ages in many countries. Due to intestinal blood loss and reduced iron absorption, ID is a threat to IBD patients, women, and children the most. Current therapies can efficiently recover normal serum transferrin saturation and hemoglobin concentration but may cause several side effects, including intestinal inflammation. ID patients may benefit from innovative nutritional supplements that may satisfy iron needs without side effects. There is a growing interest in new iron-rich superfoods, like algae and mushrooms, which combine antioxidant and anti-inflammatory properties with iron richness.

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Acute inhibition of iron absorption by zinc

Cited by 19 publications

References 20 publications

Acute inhibition of iron bioavailability by zinc: studies in humans

Acute inhibition of iron bioavailability by zinc: studies in humans

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Iron-Enriched Nutritional Supplements for the 2030 Pharmacy Shelves

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