Acute ingestion of a novel whey-derived peptide improves vascular endothelial responses in healthy individuals: a randomized, placebo controlled trial

Ballard, Kevin D.; Bruno, Richard S.; Seip, Richard L.; Quann, Erin E.; Volk, Brittanie M.; Freidenreich, Daniel J.; Kawiecki, Diana; Kupchak, Brian R.; Chung, Min‐Yu; Kraemer, William J.; Volek, Jeff S.

doi:10.1186/1475-2891-8-34

Cited by 76 publications

(80 citation statements)

References 38 publications

(40 reference statements)

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“…16 Interestingly, whey derived peptides have previously been found to exert beneficial effects on other cardiovascular risk markers, for example, suppressing blood pressure 31 and improving endothelial function. 32 The finding in this study that the four whey fractions caused similar effects on PPL indicates that they may all constitute useful protein sources for reducing PPL in persons with T2DM. However, the fact that their effects were not compared with other protein sources such as casein, cod and gluten makes this assumption uncertain.…”

Section: Discussionmentioning

confidence: 52%

Effects of different fractions of whey protein on postprandial lipid and hormone responses in type 2 diabetes

et al. 2012

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BACKGROUND/OBJECTIVES: Exacerbated postprandial lipid responses are associated with an increased cardiovascular risk. Dietary proteins influence postprandial lipemia differently, and whey protein has a preferential lipid-lowering effect. We compared the effects of different whey protein fractions on postprandial lipid and hormone responses added to a high-fat meal in type 2 diabetic subjects. SUBJECTS/METHODS: A total of 12 type 2 diabetic subjects ingested four isocaloric test meals in randomized order. The test meals contained 100 g of butter and 45 g of carbohydrate in combination with 45 g of whey isolate (iso-meal), whey hydrolysate (hydromeal), a-lactalbumin enhanced whey (lac-meal) or caseinoglycomacropeptide enhanced whey (CGMP-meal). Plasma concentrations of triglyceride, retinyl palmitate, free fatty acid, insulin, glucose, glucagon, glucagon-like peptide 1 and glucose-dependent insulinotropic peptide were measured before and at regular intervals until 8-h postprandially. RESULTS: We found no statistical significant differences between meals on our primary variable triglyceride. The retinyl palmitate response was higher after the hydro-meal than after the iso-and lac-meal in the chylomicron-rich fraction (P ¼ 0.008) while no significant differences were found in the chylomicron-poor fraction. The hydro-and iso-meal produced a higher insulin response compared with the lac-and CGMP-meal (Po0.001). Otherwise no significant differences in the hormone responses were found in the incremental area under the curve over the 480-min period. CONCLUSIONS: A supplement of four different whey protein fractions to a fat-rich meal had similar effects on postprandial triglyceride responses in type 2 diabetic subjects. Whey isolate and whey hydrolysate caused a higher insulin response.

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Section: Discussionmentioning

confidence: 52%

Effects of different fractions of whey protein on postprandial lipid and hormone responses in type 2 diabetes

et al. 2012

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“…However, Ballard et al (56,57) , Fluegel et al (45) and Pal & Ellis (35,36) requested that their subjects consumed the protein hydrolysate and isolate mixed with water. Food vehicles may influence the physiological effects of the bioactive components, as other constituents within the food matrices can exert synergistic or antagonistic effects.…”

Section: Discussionmentioning

confidence: 99%

The impact of milk proteins and peptides on blood pressure and vascular function: a review of evidence from human intervention studies

2013

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CVD are the leading cause of death worldwide. Hypertension, a major controllable risk factor of CVD, is intimately associated with vascular dysfunction, a defect which is also now recognised to be a major, modifiable risk factor for the development of CVD. The purpose of the present review was to critically evaluate the evidence for the effects of milk proteins and their associated peptides on blood pressure (BP) and vascular dysfunction. After a detailed literature search, the number of human trials evaluating the antihypertensive effects of caseinderived peptides (excluding isoleucine-proline-proline and valine-proline-proline) was found to be limited; the studies were preliminary with substantial methodological limitations. Likewise, the data from human trials that examined the effects of whey protein and peptides were also scarce and inconsistent. To date, only one study has conducted a comparative investigation on the relative effects of the two main intact milk proteins on BP and vascular function. While both milk proteins were shown to reduce BP, only whey protein improved measures of arterial stiffness. In contrast, a growing number of human trials have produced evidence to support beneficial effects of both milk proteins and peptides on vascular health. However, comparison of the relative outcomes from these trials is difficult owing to variation in the forms of assessment and measures of vascular function. In conclusion, there is an accumulating body of evidence to support positive effects of milk proteins in improving and/or maintaining cardiovascular health. However, the variable quality of the studies that produced this evidence, and the lack of robust, randomised controlled intervention trials, undermines the formulation of firm conclusions on the potential benefits of milk proteins and peptides on vascular health.

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“…It is noteworthy that NO is regarded as an important signaling molecule in vasodilation, neurotransmission, and host immune defense (Ahn et al, 2012) and peptides from whey protein (Ballard et al, 2009), Aa-lactabumin and Ab-lactabumin (Sipola et al, 2002), ovalbumin (Matoba et al, 1999), flaxseed protein (Udenigwe and Aluko, 2012), skeletal muscle protein (Takahashi et al, 2009), and even human casein (Fujita et al, 1996) were found to enhance NO production.…”

Section: Anti-inflammatory Effectmentioning

confidence: 99%

Peptides: Production, bioactivity, functionality, and applications

Hajfathalian

Ghelichi

Moreno

et al. 2017

Critical Reviews in Food Science and Nutrition

117

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Production of peptides with various effects from proteins of different sources continues to receive academic attention. Researchers of different disciplines are putting increasing efforts to produce bioactive and functional peptides from different sources such as plants, animals, and food industry by-products. The aim of this review is to introduce production methods of hydrolysates and peptides and provide a comprehensive overview of their bioactivity in terms of their effects on immune, cardiovascular, nervous, and gastrointestinal systems. Moreover, functional and antioxidant properties of hydrolysates and isolated peptides are reviewed. Finally, industrial and commercial applications of bioactive peptides including their use in nutrition and production of pharmaceuticals and nutraceuticals are discussed.

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Acute ingestion of a novel whey-derived peptide improves vascular endothelial responses in healthy individuals: a randomized, placebo controlled trial

Abstract: Background: Whey protein is a potential source of bioactive peptides. Based on findings from in vitro experiments indicating a novel whey derived peptide (NOP-47) increased endothelial nitric oxide synthesis, we tested its effects on vascular function in humans.

Cited by 76 publications

References 38 publications

Effects of different fractions of whey protein on postprandial lipid and hormone responses in type 2 diabetes

Effects of different fractions of whey protein on postprandial lipid and hormone responses in type 2 diabetes

The impact of milk proteins and peptides on blood pressure and vascular function: a review of evidence from human intervention studies

Peptides: Production, bioactivity, functionality, and applications

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