Acute impairment of regional myocardial glucose uptake in the apical ballooning (takotsubo) syndrome

Bybee, Kevin A.; Murphy, J.M.; Prasad, Anjali; Wright, R. Scott; Lerman, Amir; Rihal, Charanjit S.; Chareonthaitawee, Panithaya

doi:10.1016/j.nuclcard.2006.01.016

Cited by 24 publications

(12 citation statements)

References 31 publications

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“…For patients with symptomatic outflow obstruction, management should include β-adrenergic blockade. 7 The treatment is generally supportive according to few cases. In hospitals which coronary angiography cannot be performed, patients should be treated like patients with myocardial infarction (Figure 4).…”

Section: Discussionmentioning

confidence: 99%

Takotsubo Cardiomyopathy: A Challenging Diagnosis for Emergency Service Clinicians!

Ocak¹

2014

JCCR

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Takotsubo cardiomyopathy (TTC) is a clinical entity characterized with transient left ventricular wall dysfunction without significant culprit obstructive coronary artery disease. For definitive diagnosis ventriculography and invasive coronary angiography are gold standard techniques. We present a case with TTC, who was first diagnosed as anterior STEMI (ST elevated myocardial infarction) in our emergency service.

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Section: Discussionmentioning

confidence: 99%

Takotsubo Cardiomyopathy: A Challenging Diagnosis for Emergency Service Clinicians!

Ocak¹

2014

JCCR

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“…Bybee et al. (82) observed more severely reduced F‐18 uptake compared with perfusion abnormalities in two of four cases, a PET ‘reverse flow‐metabolism mismatch’ pattern, that is postulated to represent myocardial stunning.…”

Section: Takotsubo Cardiomyopathymentioning

confidence: 96%

“…As coronary angiography usually reveals no evidence of epicardial coronary artery stenosis, perfusion and metabolism have been evaluated in different studies [BMIPP (beta‐methyl‐iodophenyl‐pentadecanoic acid), FDG, MIBG ( 123 I‐metaiodobenzylguanidine)]. Scintigraphic findings of reduced myocardial metabolism with F‐18 FDG combined with reduced myocardial perfusion have been previously reported only in three cases (80–82). Obunai et al.…”

Section: Takotsubo Cardiomyopathymentioning

confidence: 99%

Cardiac Imaging in Acute Coronary Syndromes and Acute Myocardial Infarction – An Update

2006

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Summary Myocardial perfusion imaging (MPI) using nuclear techniques is a well‐established diagnostic tool in the management of patients after acute coronary syndromes (ACS) or acute myocardial infarction (AMI) providing non‐invasively information about perfusion and function. Single photon emission computed tomography (SPECT) is routinely applied for MPI allowing the characterization of localization, extent and severity of perfusion abnormalities. Gated SPECT MPI is a technique that can accurately define the individual patient risk among clinically stable survivors of AMI, assessing the total left ventricular (LV) perfusion defect size, the extent of inducible ischaemia and the degree of LV dysfunction. The documented prognostic value of these scintigraphic parameters is of clinical importance to guide decision making in the cardiac patient. Moreover, the cost effectiveness of implemented MPI in the work‐up of patients after AMI has been demonstrated. Metabolic imaging with F‐18 deoxyglucose positron emission tomography (PET) is currently the most advanced scintigraphic imaging technique developed for in vivo assessment of tissue viability, providing clinical valuable information about the presence and extent of viable myocardium in patients with coronary artery disease. Whether this technique will be valuable for patients with ACS or AMI has not been established, yet. However, PET technology offers fascinating opportunities to investigate the distinct pathophysiological pathways in acute and chronic cardiac disease. Imaging of stunning in Takotsubo cardiomyopathy is an example of how nuclear medicine techniques contribute to the understanding of cardiac disease.

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“…10 In addition, spasm could be a secondary symptom resulting from administration of epinephrine in SIC patient who presented with bradycardic arrest. 11 Although abnormal myocardial perfusion defects have been reported in the affected wall of SIC cases, 12,13 the precise role of coronary microvascular dysfunction is not yet established. 9 Recent data suggested the role of stress-induced cathecholamine mediated myocardial injury.…”

Section: Pathophysiologymentioning

confidence: 99%

Reversible Stress-induced Cardiomyopathy (Takotsubo) Mimics Acute Anterior Wall ST Segment Elevation Myocardial Infarction: A Case Report with Review of Literature

Veerakul¹,

Kiattipoom²,

Tawatchai³

et al. 2016

bkkmedj

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We reported a transient stress-induced cardiomyopathy (SIC) in a 73-year-old woman who manifested with the setting of ST segment elevation myocardial infarction condition. She was initially complicated by heart failure from both systolic and diastolic dysfunction but had a fast recovery within 3 days. The trigger in this case was pneumonia of the right lower lung which responded well to medical therapy. The proposed pathophysiologic mechanisms and outcome had been reviewed. Currently, SIC was no longer considered a benign condition since the in-hospital complication rates were not different from those of ACS patients.

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Acute impairment of regional myocardial glucose uptake in the apical ballooning (takotsubo) syndrome

Abstract: In all 4 patients, affected regions subsequently recovered regional LV systolic function within 6 weeks.

Cited by 24 publications

References 31 publications

Takotsubo Cardiomyopathy: A Challenging Diagnosis for Emergency Service Clinicians!

Takotsubo Cardiomyopathy: A Challenging Diagnosis for Emergency Service Clinicians!

Cardiac Imaging in Acute Coronary Syndromes and Acute Myocardial Infarction – An Update

Reversible Stress-induced Cardiomyopathy (Takotsubo) Mimics Acute Anterior Wall ST Segment Elevation Myocardial Infarction: A Case Report with Review of Literature

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