Acute illnesses associated with exposure to fipronil—surveillance data from 11 states in the United States, 2001–2007

Abstract

Our findings indicate that exposure to fipronil can pose a risk for mild, temporary health effects in various body systems. Precautionary actions should be reinforced to prevent fipronil exposure to product users.

Role of Environmental Contaminants in the Etiology of Alzheimer’s Disease: A Review

“…Experiments in zebrafish embryos suggest that fipronil impairs spinal locomotor pathways and causes neurodegeneration [ 96 ]. In humans, exposure to fipronil causes an increased risk of mild, temporary health effects, including neurological symptoms [ 97 ]. Examination of the human AD brain showed functional remodeling of GABAergic neurotransmission similar to fipronil toxicity [ 98 ] suggesting that long term exposure to fipronil may be a predisposing factor for AD.…”

Comparative effects of fipronil and its metabolites sulfone and desulfinyl on the isolated rat liver mitochondria

“…In the first instance, fipronil does not represent a severe toxic agent to mammals; however, any species may be affected if the dose is greater than that recommended by the manufacturers. According to reports in the literature, there are cases of poisoning due to accidental exposure or incorrect use of the compound (Chodorowski and Anand, 2004;Lee et al, 2010). A case of acute poisoning after ingestion of a high fipronil dose caused human death (Mohamed et al, 2004).…”

Firpronil induced spermotoxicity is associated with oxidative stress, DNA damage and apoptosis in male rats

“…In addition, FPN induced a statistically significant increase in the micronuclei and sister chromatid exchange frequency and DNA damage in a dose-dependent manner in human peripheral blood lymphocytes [23]. FPN exposure through application on animals as insecticide [24,25] and consumption of different food products containing FPN residues [26,27] indicating risks to human health [28]. In this regard, of course, rising incidence of infertility in male with DNA fragmentation and chromatin damage in sperms and impairing testicular function represents a group of major concern worldwide.…”