Comparative effects of fipronil and its metabolites sulfone and desulfinyl on the isolated rat liver mitochondria

Tavares, Marco Aurélio; Palma, Ivo Dias Ferreira da; Medeiros, Hyllana C. D.; Guelfi, Marieli; Santana, Andréia Tieme de; Mingatto, Fábio Ermínio

doi:10.1016/j.etap.2015.06.013

Cited by 32 publications

(13 citation statements)

References 46 publications

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“…Fipronil also affected the mitochondrial membrane potential of hepatocytes in a dose-dependent manner. These results agreed with those obtained by Tavares et al (2015), who evaluated the effects of fipronil on the isolated mitochondria of rat liver. By inhibiting the electron transport chain and the formation of the mitochondrial membrane potential, it would be expected that fipronil reduced the intracellular concentration of ATP.…”

Section: Discussionsupporting

confidence: 91%

“…These results indicated that fipronil inhibited the respiratory chain complex I of mitochondria as assessed in isolated hepatocytes. These results agreed with those previously described that showed fipronil as an inhibitor of the complex I in isolated mitochondria (Tavares et al 2015). …”

Section: Effects Of Fipronil On the Respiration Of Mitochondria In Issupporting

confidence: 94%

“…When hepatocytes were exposed to fipronil, an increase in cytosolic Ca 2+ occurred. This effect could be a result of the release of mitochondrial calcium as observed in the studies that were conducted using isolated rat liver mitochondria (Tavares et al 2015). Another hypothesis was that the fipronil-induced mitochondrial dysfunction reducing cellular ATP levels could (in organelles such as the endoplasmic reticulum) promote the inactivation of the pump that was responsible for the maintenance of the ion gradient in the cytoplasm (Thastrup et al 1990;Lytton et al 1991).…”

Section: Discussionmentioning

confidence: 98%

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Citotoxicity of Fipronil on Hepatocytes Isolated from Rat and Effects of Its Biotransformation

Guelfi

Maioli

Tavares

et al. 2015

Braz. arch. biol. technol.

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Section: Discussionsupporting

confidence: 91%

Section: Effects Of Fipronil On the Respiration Of Mitochondria In Issupporting

confidence: 94%

Section: Discussionmentioning

confidence: 98%

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Citotoxicity of Fipronil on Hepatocytes Isolated from Rat and Effects of Its Biotransformation

Guelfi

Maioli

Tavares

et al. 2015

Braz. arch. biol. technol.

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“…Bee larvae that were fed sublethal doses of thiamethoxam by Tavares et al (2015a) showed condensed cells and early cell death in the optical lobe part of the brain, as well as dosedependent effects on development speed and body size.…”

Section: Sublethal Effects Due To Ontogenic Exposurementioning

confidence: 99%

An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides. Part 2: impacts on organisms and ecosystems

Pisa

Goulson

Yang

et al. 2017

Environ Sci Pollut Res

174

133

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New information on the lethal and sublethal effects of neonicotinoids and fipronil on organisms is presented in this review, complementing the previous Worldwide Integrated Assessment (WIA) in 2015. The high toxicity of these systemic insecticides to invertebrates has been confirmed and expanded to include more species and compounds. Most of the recent research has focused on bees and the sublethal and ecological impacts these insecticides have on pollinators. Toxic effects on other invertebrate taxa also covered predatory and parasitoid natural enemies and aquatic arthropods. Little new information has been gathered on soil organisms. The impact on marine and coastal ecosystems is still largely uncharted. The chronic lethality of neonicotinoids to insects and crustaceans, and the strengthened evidence that these chemicals also impair the immune system and reproduction, highlights the dangers of this particular insecticidal class (neonicotinoids and fipronil), with the potential to greatly decrease populations of arthropods in both terrestrial and aquatic environments. Sublethal effects on fish, reptiles, frogs, birds, and mammals are also reported, showing a better understanding of the mechanisms of toxicity of these insecticides in vertebrates and their deleterious impacts on growth, reproduction, and neurobehaviour of most of the species tested. This review concludes with a summary of impacts on the ecosystem services and functioning, particularly on pollination, soil biota, and aquatic invertebrate communities, thus reinforcing the previous WIA conclusions .

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“…47 Tavares ve ark., rat karaciğer mitokondrisinde fipronil, fipronil sülfon ve fipronil desülfinil maruziyetinin doza bağımlı olarak mitokondriyal Ca 2+ 'un dışarı salınımının artmasına ve apoptozu uyarmasına neden olduğunu göstermişlerdir. 33…”

Section: Fi̇proni̇l Toksi̇si̇tesi̇nde Hücre Si̇nyal Yolaklariunclassified

General Properties of Fipronil and the Mechanisms of its Toxicity

Gökmen¹,

Güvenç²

2018

Turkiye Klinikleri J Vet Sci

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Comparative effects of fipronil and its metabolites sulfone and desulfinyl on the isolated rat liver mitochondria

Cited by 32 publications

References 46 publications

Citotoxicity of Fipronil on Hepatocytes Isolated from Rat and Effects of Its Biotransformation

Citotoxicity of Fipronil on Hepatocytes Isolated from Rat and Effects of Its Biotransformation

An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides. Part 2: impacts on organisms and ecosystems

General Properties of Fipronil and the Mechanisms of its Toxicity

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