Acute Hepatitis Induced by Pure Garcinia cambogia

Melendez-Rosado, Jose; Snipelisky, David; Matcha, Guatam; Stancampiano, Fernando

doi:10.1097/mcg.0000000000000303

Cited by 24 publications

(19 citation statements)

References 6 publications

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“…The majority of G. cambogia formulation associated with hepatotoxicity have been mixed supplements were a definitive causal relation could not be drawn. However, in the past several months, several cases of G. cambogia associated acute liver failure have been reported[18,19], reinforcing the toxic potential of this particular supplement. Agreement upon the actual liver toxicity of G. cambogia has been mixed, and the majority of evidence is drawn from rodent models[20].…”

Section: Discussionmentioning

confidence: 99%

Dangerous dietary supplements:Garcinia cambogia-associated hepatic failure requiring transplantation

Lunsford¹,

Bodzin²,

Reino³

et al. 2016

WJG

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Commercial dietary supplements are marketed as a panacea for the morbidly obese seeking sustainable weight-loss. Unfortunately, many claims cited by supplements are unsupported and inadequately regulated. Most concerning, however, are the associated harmful side effects, often unrecognized by consumers. Garcinia cambogia extract and Garcinia cambogia containing products are some of the most popular dietary supplements currently marketed for weight loss. Here, we report the first known case of fulminant hepatic failure associated with this dietary supplement. One active ingredient in this supplement is hydroxycitric acid, an active ingredient also found in weight-loss supplements banned by the Food and Drug Administration in 2009 for hepatotoxicity. Heightened awareness of the dangers of dietary supplements such as Garcinia cambogia is imperative to prevent hepatoxicity and potential fulminant hepatic failure in additional patients.

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Section: Discussionmentioning

confidence: 99%

Dangerous dietary supplements:Garcinia cambogia-associated hepatic failure requiring transplantation

Lunsford¹,

Bodzin²,

Reino³

et al. 2016

WJG

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“…According to the FDA, this action was based on 23 reports of serious health problems ranging from jaundice and elevated liver enzymes, to liver damage requiring liver transplant, and one death linked to liver damage (Food and Drug Administration, 2009). There are also case reports of pancreatitis in response to the ingestion of supplements containing hydroxycitric acid, sometimes labelled as Garcinia Cambogia (Melendez-Rosado et al, 2015;Grigos et al,2016). In these cases, the adverse outcomes can be related to the known presence of harmful agents in the supplements.…”

Section: Adverse Health Outcomes From Supplement Usementioning

confidence: 99%

Making Decisions About Supplement Use

Maughan

Shirreffs

Vernec

2018

International Journal of Sport Nutrition and Exercise Metabolism

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The use of dietary supplements is widespread among athletes in all sports and at all levels of competition, as it is in the general population. For the athlete training at the limits of what is sustainable, or for those seeking a shortcut to achieving their aims, supplements offer the prospect of bridging the gap between success and failure. Surveys show, however, that this is often not an informed choice and that the knowledge level among consumers is often low and that they are often influenced in their decisions by individuals with an equally inadequate understanding of the issues at stake. Supplement use may do more harm than good, unless it is based on a sound analysis of the evidence. Where a deficiency of an essential nutrient has been established by appropriate investigations, supplementation can provide a rapid and effective correction of the problem. Supplements can also provide a convenient and time-efficient solution to achieving the necessary intake of key nutrients such as protein and carbohydrate. Athletes contemplating the use of supplements should consider the potential for both positive and negative outcomes. Some ergogenic supplements may be of benefit to some athletes in some specific contexts, but many are less effective than is claimed. Some may be harmful to health of performance and some may contain agents prohibited by anti-doping regulations. Athletes should make informed choices that maximize the benefits while minimizing the risks.

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“…132 A week after the consumption of G. cambogia, the levels of alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and ferritin of a 42-year-old female were 1277 U/L (normal range: 7-40 U/L), 2792 U/L (normal range: 5-50 U/L), 283 U/L (normal range: 40-150 U/L) and 12,198 mcg/L (normal range: 11-307 mcg/L) respectively. 133 The same case was described by Mancano (2015) as awareness to the public regarding drug interactions. 134 Following the consumption of G. cambogia, the levels of alanine aminotransferase, aspartate aminotransferase and bilirubin of a 52-year-old female were found to be 568 U/L (normal range: 7-40 U/L), 723 U/L (normal range: 5-50 U/L) and 10.1 mg/dL (normal range: 0.0-1.5 mg/dL) respectively.…”

Section: Resultsmentioning

confidence: 82%

Awareness on the possible adverse effects of Garcinia cambogia: A scientific approach

Zothantluanga

Lalnunpuii

Bhat

et al. 2020

Sci Vis

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The modern popular ideology is that plant-based products do not have adverse effects. Hence, people are fond of using herbal products of their choice to treat their own ailments or anyone else. As majority of the population are not aware of herbal toxicity concept, the use of formulated single or combined medicinal and/or nutritional plant extracts or isolated compounds to treat chronic diseases are increasingly popular due to the widespread concerns regarding the adverse effects of pharmaceutical drugs. Awareness from the scientific community to bring society to its senses regarding the safety issue of a herbal product is rare. Garcinia gummi-gutta (more popularly known by the synonym Garcinia cambogia in commercial preparations), belonging to the family of Clusiaceae (alt. Guttiferae) is a popularly consumed weight-loss nutraceutical. This review aims to highlight the possible adverse effects of G. cambogia. For the said purpose, 147 articles were collected from PubMed, Web of Science and Google scholar. Literature review revealed a plethora of beneficial actions. Investigational outcomes and clinical evidences hint the possible adverse effects likely to be linked with the use of G. cambogia. However, the use of G. cambogia as an anti-obesity agent is advisable as long as the therapeutic value outweighs the adverse effect.

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Acute Hepatitis Induced by Pure Garcinia cambogia

Cited by 24 publications

References 6 publications

Dangerous dietary supplements:Garcinia cambogia-associated hepatic failure requiring transplantation

Dangerous dietary supplements:Garcinia cambogia-associated hepatic failure requiring transplantation

Making Decisions About Supplement Use

Awareness on the possible adverse effects of Garcinia cambogia: A scientific approach

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