Acute, hepatitis-A super-infection in HBV carriers, or chronic liver disease related to HBV or HCV

Pramoolsinsap, Chutima; Poovorawan, Yong; Hirsch, Petra; Busagorn, N; Attamasirikul, K.

doi:10.1080/00034983.1999.11813480

Cited by 33 publications

(29 citation statements)

References 21 publications

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“…Under the current circumstances, the benefits of hepatitis-A vaccination administered to the general population in Thailand would not justify the expenses incurred (Teppakdee et al, 2002). Currently, it would only make sense to vaccinate high-risk groups such as children and staff in day-care centres, those in close contact with infected individuals, travellers to endemic areas, those living in over-crowded conditions, such as many military personnel (WHO, 2000), and individuals with chronic liver disease (Pramoolsinsap et al, 1999;WHO, 2000;Poovorawan et al, 2005).…”

Section: Resultsmentioning

confidence: 99%

“…HAV infection in early childhood is usually subclinical but infection later in life usually produces symptoms, the likelihood of an infection becoming symptomatic increasing with the age of the subject (Hadler et al, 1980). HAV causes severe or fulminant viral hepatitis in approximately 0.1%-0.35% of symptomatic cases (Pappas, 1995), patients with underlying diseases, such as chronic hepatitis or liver cirrhosis, being much more prone to severe hepatitis A than otherwise healthy individuals (Yao, 1991;Pramoolsinsap et al, 1999).…”

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confidence: 99%

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Declining trend in the seroprevalence of infection with hepatitis A virus in Thailand

Chatproedprai

Chongsrisawat

Chatchatee

et al. 2007

Annals of Tropical Medicine & Parasitology

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Since the mid 1970s, infection with hepatitis A virus (HAV) in Thailand has shifted from hyper-endemic to mesoendemic. In 2004, to explore this trend in prevalence further, 3997 subjects from four geographically distinct provinces of Thailand were tested, in a commercial ELISA, for antibodies to HAV. The results indicate that the seroprevalence of HAV continues to fall, almost certainly because the profound socio-economic development that has occurred over the last few decades in Thailand has brought with it significant improvements in sanitation and personal hygiene. As exposure to HAV declines, however, the risks of symptomatic and potentially severe infection in adulthood (rather than asymptomatic infection during childhood) and of epidemics of such infection, which would lead to profound economic loss, increases. Improvements in hygiene and sanitation to reduce exposure to the virus and measures to reduce the incidence of symptomatic disease in those infected, such as vaccination (which may only be cost-effective when targeted at high-risk groups), need to be carefully considered.

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Section: Resultsmentioning

confidence: 99%

mentioning

confidence: 99%

Declining trend in the seroprevalence of infection with hepatitis A virus in Thailand

Chatproedprai

Chongsrisawat

Chatchatee

et al. 2007

Annals of Tropical Medicine & Parasitology

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“…Numerous other studies have also identified chronic liver disease as a risk factor for fulminant hepatitis and death from acute HAV infection. 4,[16][17][18][19][20][21][22] Based on the potential risk for fulminant hepatic failure and death from acute HAV superinfection, the 1996 Advisory Committee on Immunization Practices recommended HAV vaccination for all patients with chronic liver disease, including those with chronic HCV infec-tion. 23 These recommendations have also been endorsed by the World Health Organization, 24 the National Institutes of Health, 25 the United States Veterans Health Administration, 26 the American Association for the Study of Liver Diseases, 27 the American Liver Foundation, 28 the American College of Gastroenterology, 29 and others.…”

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confidence: 99%

Susceptibility to hepatitis A in patients with chronic liver disease due to hepatitis C virus infection: Missed opportunities for vaccination

et al. 2005

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“…The possibility of a severe clinical course has, however, been suggested by some reports from Asia. For example, in a study from Thailand, 29% of patients with HAV superinfection died, and all of them were older than 50 (2 of the 3 superinfected patients in the present study were in this age group) [22,23]. Authors from South Korea found a 22-fold increase in the risk of fulminant hepatitis in hepatitis A superimposed on HBsAg carriage; in their analysis, this clinical scenario was observed in 12% of the cases [24].…”

Section: Discussionmentioning

confidence: 98%

Viral Hepatitis A in 108 Adult Patients During an Eight-Year Observation in a Single Center in Poland

Bura¹,

Michalak²,

Chojnicki³

et al. 2015

Adv Clin Exp Med

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Background. Hepatitis A is related to significant morbidity and occasional mortality. Based on data from the Polish National Institute of Hygiene, from 2000 to 2013 a mean of 213 hepatitis A cases were reported yearly. Objectives. The aim of the study was to assess selected data in adults hospitalized for symptomatic hepatitis A during an eight-year period in a single center in the Wielkopolska Region of Poland. Material and Methods. All the hepatitis A patients hospitalized in the center from 2005 to 2013 were analyzed retrospectively. Data were extracted from the medical records of these individuals. The disease was confirmed by anti-HAV IgM testing. Results. In total, 108 patients (71 men and 37 women), aged 18-65 years, were identified. All but 1 patient recovered (99.1%) and in 6 cases (5.6%) a relapse occurred. Risk factors for hepatitis A were identified in 56 patients (52%), with travel abroad being the most common one (32 patients); 19 cases were secondary and 5 patients were men who have sex with men. One hepatitis A outbreak was noted in the region during the study period. Acalculous cholecystitis was found in 33.3% of the patients who underwent abdominal ultrasound. This tended to be more common among older individuals (47.8% in patients over 40 vs. 22.6% in patients aged 18-40, p = 0.0521). Patients with this finding had significantly higher mean peak ALT in comparison to those with no gallbladder abnormalities. Conclusions. Although hepatitis A in adults is typically a benign, self-limited disease, it can occasionally have a fatal course. In a significant proportion of patients with an evident risk factor for hepatitis A, the possibility of active prophylaxis was not used. Hepatitis A should be regarded as a sexually transmitted infection. Acalculous cholecystitis is a frequent finding among adults with symptomatic hepatitis A (Adv Clin Exp Med 2015, 24, 5, 829-836).

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Acute, hepatitis-A super-infection in HBV carriers, or chronic liver disease related to HBV or HCV

Cited by 33 publications

References 21 publications

Declining trend in the seroprevalence of infection with hepatitis A virus in Thailand

Declining trend in the seroprevalence of infection with hepatitis A virus in Thailand

Susceptibility to hepatitis A in patients with chronic liver disease due to hepatitis C virus infection: Missed opportunities for vaccination

Viral Hepatitis A in 108 Adult Patients During an Eight-Year Observation in a Single Center in Poland

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