Acute Hepatic Failure in Seven Patients After Prophylaxis and Therapy With Antituberculous Agents

Meyers, Burt R.; Halpern, M. J.; Sheiner, Patricia A.; Mendelson, Meryl H.; Miller, Charles M.; Schwartz, Myron; Mor, Eytan

doi:10.1097/00007890-199408150-00022

Cited by 8 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Meyers et al have shown that continued therapy with ethambutol and fluoroquinolones is effective in liver transplant patients who show hepatotoxicity to the conventional drug regimen (36). Similarly, in those patients who are transplanted secondary to fulminant hepatic failure from either conventional therapy or treatment of latent tuberculosis, successful continuation of treatment with second-line TB drugs has been reported (16,17,39,40). It must be noted that the efficacy of second-line regiments is yet to be proven in large scale clinical trials, and as mentioned previously, even first-line agent therapy for active TB on the posttransplant scenario is associated with high morbidity.…”

Section: Discussionmentioning

confidence: 99%

Safety of Treatment of Latent Tuberculosis Infection in Compensated Cirrhotic Patients During Transplant Candidacy Period

Jahng¹,

Tran²,

Bui³

et al. 2007

Transplantation

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Safety of Treatment of Latent Tuberculosis Infection in Compensated Cirrhotic Patients During Transplant Candidacy Period

Jahng¹,

Tran²,

Bui³

et al. 2007

Transplantation

View full text Add to dashboard Cite

show abstract

“…Such a distinc,tion has obvious implications in the treatment strategy choice (OLT, APOLT, bio-artificial bridging procedures, medical therapy) when this type of FHF occurs. Several cases of successful OLT for TNH-related FHF have been described in the past decade [9], but, to the best of our knowledge, we report here on the first case of APOLT for INH-related FHF.…”

Section: Discussionmentioning

confidence: 83%

Isoniazid-related fulminant hepatic failure in a child: assessment of the native liver's early regeneration after auxiliary partial orthotopic liver transplantation

et al. 2004

View full text Add to dashboard Cite

We report the first case of auxiliary partial orthotopic liver transplantation (APOLT) in a patient with isoniazid (1NH)-related fulminant hepatic failure (FHF) with the aim to determine the ability of the native liver (NL) to recover after this particular toxic event. A 10-year-old boy with INH-related FHF underwent APOLT after left hepatectomy on the NL. Neurological status and liver function rapidly improved, but, on postoperative day 22, urgent re-transplantation was needed for graft-hepatic artery thrombosis (HAT) and the NL's incapacity to sustain adequate liver function. Histological examination of the NL showed signs evident of its regeneration; however. In conclusion, though we faced the clinical failure of the NL functionally to sustain the patient in the presence of the graft HAT 3, weeks after APOLT, such a failure may be interpreted as time related. In fact, the histological picture in this particular case may suggest the potential for NL recovery after INH-related FHF.

show abstract

“…However, INH prophylaxis is still infrequently initiated or even discontinued due to the elevation of transaminase levels. In fact, some experts believe that in liver transplant recipients, the risks of using INH outweigh its potential benefits …”

Section: Discussionmentioning

confidence: 99%

Treatment of latent TB Infection and the risk of tuberculosis after solid organ transplantation: Comprehensive review

Abad

Deziel

Razonable

2019

Transplant Infectious Dis

View full text Add to dashboard Cite

Background: Mycobacterium tuberculosis disease may occur after treatment of latent TB infection (LTBI). Prompted by a case of reactivation TB disease in a solid organ transplant (SOT) recipient who received LTBI treatment, we reviewed the literature to examine outcomes, adverse effects, resistance, and treatment choices of tuberculosis after LTBI therapy.Methods: MEDLINE and Web of Science from inception to 5/2019 were reviewed using key words "latent tuberculosis infection" and "SOT" or "transplantation." The search yielded nine cases, 41 cohort studies and six randomized controlled trials (RCT). Results: Cohort and RCT demonstrated significant reduction in TB disease among transplanted patients who received LTBI therapy; only 56/2651 (2.1%) SOT patients developed TB after LTBI therapy. Adverse drug reactions occurred in 149/1148 (12.9%) and 73/641 (11.4%) of cohort and RCT patients, respectively. Among liver recipients, 56/266 (21%) developed side effects, of which half (29/56, 51.8%) was INH-related. There was no reported INH resistance. Conclusions: Latent TB infection treatment is efficacious in SOT recipients at risk of TB disease. However, tuberculosis may still occur despite LTBI treatment. Hepatotoxicity associated with LTBI therapy is infrequent, although more commonly observed among liver recipients. K E Y W O R D S latent TB, Mycobacterium tuberculosis, solid organ transplant

show abstract

Acute Hepatic Failure in Seven Patients After Prophylaxis and Therapy With Antituberculous Agents

Cited by 8 publications

References 0 publications

Safety of Treatment of Latent Tuberculosis Infection in Compensated Cirrhotic Patients During Transplant Candidacy Period

Safety of Treatment of Latent Tuberculosis Infection in Compensated Cirrhotic Patients During Transplant Candidacy Period

Isoniazid-related fulminant hepatic failure in a child: assessment of the native liver's early regeneration after auxiliary partial orthotopic liver transplantation

Treatment of latent TB Infection and the risk of tuberculosis after solid organ transplantation: Comprehensive review

Contact Info

Product

Resources

About