Acute Hematogenous Osteomyelitis in a Five-Month-Old Male with Rickets

Abstract

Osteomyelitis is defined as an infection of the bone, bone marrow, and the surrounding soft tissues. Most cases of acute hematogenous osteomyelitis in children are caused by Gram-positive bacteria, principally Staphylococcus aureus. We present a case where a 5-month-old male had an acute onset of decreased movement of his left leg and increased irritability and was subsequently diagnosed with rickets and hematogenous osteomyelitis with bacteremia. The case explores a possible association between hematogenous osteomyelitis and rickets.

Vitamin D-Dependent Rickets Type 1A in Two Siblings with a Hypomorphic CYP27B1 Variant Frequent in the African Population

“…Previously, John et al described an infant with osteomyelitis, who had nutritional rickets caused by vitamin D deficiency. 18 Maier et al found that vitamin D deficiency was severe in patients with periprosthetic joint infection, recognizing vitamin D as an important mediator of immune function and it may have a preventive role in the pathogenesis of periprosthetic joint infection. 19 Moreover, osteomyelitis is less common in developed countries than in developing countries, 18 where although there may be less sun exposure, there are also fewer nutritional deficits.…”

“…18 Maier et al found that vitamin D deficiency was severe in patients with periprosthetic joint infection, recognizing vitamin D as an important mediator of immune function and it may have a preventive role in the pathogenesis of periprosthetic joint infection. 19 Moreover, osteomyelitis is less common in developed countries than in developing countries, 18 where although there may be less sun exposure, there are also fewer nutritional deficits. So, in patients with rickets, we should be aware of a possible increased risk of bone or joint infection.…”

Characteristics of rickets in a referral hospital in Khartoum-Sudan

“…Rickets also reduces the body immune and the child become more susceptible to infectious disease especially osteomyelitis as stated by John and colleagues. 13…”

“…11 There is an association between rickets and some infectious diseases like hematogenous osteomyelitis in children. 13 In the differential diagnosis of different forms of rickets; the detailed family history, physical examination, biochemical assessment and X-ray imaging are required. 11,2 This study aimed to find the characteristics of rickets at JafarIbn Auf pediatric hospital in Sudan.…”