Acute Heart Rate-Dependent Hemodynamic Function of the Heart in the Post-Myocardial Infarction Rat Model: Change Over Time

Paterek, Aleksandra; Kępska, Marta; Kołodziejczyk, Joanna; Leszek, Przemysław; Mackiewicz, Urszula; Mączewski, Michał

doi:10.1016/j.cjca.2018.08.009

Cited by 11 publications

(10 citation statements)

References 32 publications

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“…As reported previously 18 , rats were put on a heating pad, anesthetized with 2% isoflurane (oxygen was used as a carrier gas, flow rate 0.5 l/min, providing fraction of inspired oxygen [FiO 2 ] of 40%), intubated and put on an animal ventilator. The upper abdominal cavity was opened and the heart was exposed through cutting of the diaphragm.…”

Section: Methodsmentioning

confidence: 99%

Right ventricular myocardial oxygen tension is reduced in monocrotaline-induced pulmonary hypertension in the rat and restored by myo-inositol trispyrophosphate

Oknińska

Zambrowska

Zajda

et al. 2021

Sci Rep

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Pulmonary hypertension (PH) initially results in compensatory right ventricular (RV) hypertrophy, but eventually in RV failure. This transition is poorly understood, but may be triggered by hypoxia. Measurements of RV oxygen tension (pO2) in PH are lacking. We hypothesized that RV hypoxia occurs in monocrotaline-induced PH in rats and that myo-inositol trispyrophosphate (ITPP), facilitating oxygen dissociation from hemoglobin, can relieve it. Rats received monocrotaline (PH) or saline (control) and 24 days later echocardiograms, pressure–volume loops were obtained and myocardial pO2 was measured using a fluorescent probe. In PH mean pulmonary artery pressure more than doubled (35 ± 5 vs. 15 ± 2 in control), RV was hypertrophied, though its contractility was augmented. RV and LV pO2 was 32 ± 5 and 15 ± 8 mmHg, respectively, in control rats. In PH RV pO2 was reduced to 18 ± 9 mmHg, while LV pO2 was unchanged. RV pO2 correlated with RV diastolic wall stress (negatively) and LV systolic pressure (positively). Acute ITPP administration did not affect RV or LV pO2 in control animals, but increased RV pO2 to 26 ± 5 mmHg without affecting LV pO2 in PH. RV oxygen balance is impaired in PH and as such can be an important target for PH therapy. ITPP may be one of such potential therapies.

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Section: Methodsmentioning

confidence: 99%

Right ventricular myocardial oxygen tension is reduced in monocrotaline-induced pulmonary hypertension in the rat and restored by myo-inositol trispyrophosphate

Oknińska

Zambrowska

Zajda

et al. 2021

Sci Rep

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“…The untreated loops (Figure 4A,B) seem to be smaller, shifted to the right, and tend not to cross the x-axis, which is characteristic of weaker cardiac muscle. 35 On the other hand, the PV loops taken from electrospun ECM patched (thin or thick, Figure 4C-F) animals, look wider and close to the origin of the coordinate system, which represents cardiac structural and pathophysiological changes corresponding to post-MI remodeling. 36 Moderated remodeling was seen both by echocardiography and using a direct cardiac function assessment.…”

Section: Resultsmentioning

confidence: 87%

“…Figure 4 depicts representative pairs of PV loops obtained from each of the experimental groups at the final time point. The untreated loops (Figure 4A,B) seem to be smaller, shifted to the right, and tend not to cross the x‐axis, which is characteristic of weaker cardiac muscle 35 . On the other hand, the PV loops taken from electrospun ECM patched (thin or thick, Figure 4C–F) animals, look wider and close to the origin of the coordinate system, which represents cardiac structural and pathophysiological changes corresponding to post‐MI remodeling 36 .…”

Section: Resultsmentioning

confidence: 97%

Electrospun extracellular matrix scaffold improves cardiac structure and function post‐myocardial infarction

Hayam

Ertracht

Zahran

et al. 2022

Polymers for Advanced Techs

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The current unmet clinical need for post-myocardial infarction (MI) treatments has driven the development of diverse scaffolds for regenerating the infarcted area, based on natural and synthetic polymers. Decellularized porcine cardiac extracellular matrix (pcECM) has emerged as a promising biomaterial for cardiac regeneration, due to its unique bioactivity and microstructure that mimic the natural tissue. We have previously reported the development of an electrospun pcECM cardiac scaffold that was shown to preserve the mechanical, structural, and biological properties of cardiac ECM while allowing a controllable reproducible production. In the present work, however, we reveal the potential of this unique scaffold as a possible treatment post-MI. Two types of electrospun pcECM scaffolds, varying in thickness, were applied to rat hearts, 4 weeks following MI induction, thus allowing cardiac deterioration and a scar tissue formation before treatment (chronic model). Our results show moderated remodeling, decreased scar, and reduced wall thinning accompanied by a partial functional recovery in the hearts of both treatment groups when compared to the control.

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“…Most recently, Joo’s study found no association between beta-blocker treatment and outcomes on post-MI with regard to preserved LVEF among enrolled 13,624 patients [ 23 ]. In essence, the cardiac output stimulated by an increased RHR was elevated within 7 days and, followed by decling within 1 to 2 months after AMI in a rat model [ 24 ]. Moreover, further beneficial effects of RHR reduction on the left ventricular diastolic pressure and increased ejection fraction were observed within 1 to 2 months.…”

Section: Discussionmentioning

confidence: 99%

Prediction of SYNTAX score II improvement by adding temporal heart rate changes between discharge and first outpatient visit in patients with acute myocardial infarction

Yang

Zhang

et al. 2022

BMC Cardiovasc Disord

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Background The prognostic ability of the temporal changes in resting heart rate (ΔHR) in patients with acute myocardial infarction (AMI) for cardiovascular (CV) mortality and clinical outcomes is rarely examined. This study investigated the predictive value of ΔHR using models with SYNTAX score II (SxS-II) for the long-term prognosis of patients with AMI. Methods Six hundred five AMI patients with vital signs recorded at the first outpatient visit (2–4 weeks after discharge) were retrospectively recruited into this study. The changes between discharge and outpatient resting heart rate (D-O ΔHR) were calculated by subtracting the HR at the first post-discharge visit from the value recorded at discharge. The major adverse cardiovascular and cerebrovascular events (MACCE) include cardiovascular death, recurrent myocardial infarction, revascularization, and nonfatal stroke. The predictive values and reclassification ability of the different models were assessed using a likelihood ratio test, Akaike’s information criteria (AIC), receiver operating characteristic (ROC) curves, net reclassification improvement (NRI), and integrated discrimination improvement (IDI). Results During the follow-up period, a drop-in resting heart rate (RHR) from discharge to first outpatient visit was independently associated with less risk of CV mortality [D-O ΔHR: hazards ratio (HR) = 0.97, 95% CI = 0.96–0.99, P < 0.001] and MACCE (HR = 0.98, 95% CI = 0.97–0.99, p = 0.001). The likelihood test indicated that the combined model of SxS-II and D-O ΔHR yielded the lowest AIC for CV mortality and MACCE (P < 0.001). Moreover, D-O ΔHR alone significantly improved the net reclassification and integrated discrimination of the models containing SxS-II for CV mortality and MACCE (CV mortality: NRI = 0.5600, P = 0.001 and IDI = 0.0759, P = 0.03; MACCE: NRI = 0.2231, P < 0.05 and IDI = 0.0107, P < 0.05). Conclusions The change in D-O ΔHR was an independent predictor of long-term CV mortality and MACCE. The D-O ΔHR combined with SxS-II could significantly improve its predictive probability.

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Acute Heart Rate-Dependent Hemodynamic Function of the Heart in the Post-Myocardial Infarction Rat Model: Change Over Time

Cited by 11 publications

References 32 publications

Right ventricular myocardial oxygen tension is reduced in monocrotaline-induced pulmonary hypertension in the rat and restored by myo-inositol trispyrophosphate

Right ventricular myocardial oxygen tension is reduced in monocrotaline-induced pulmonary hypertension in the rat and restored by myo-inositol trispyrophosphate

Electrospun extracellular matrix scaffold improves cardiac structure and function post‐myocardial infarction

Prediction of SYNTAX score II improvement by adding temporal heart rate changes between discharge and first outpatient visit in patients with acute myocardial infarction

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