Acute Graft-Versus-Host-Disease in Kidney Transplantation: Case Report and Review of Literature

Kato, Taigo; Yazawa, Koji; Madono, Keigo; Saito, Jun; Hosomi, Masahiro; Itoh, Kiichiro

doi:10.1016/j.transproceed.2009.05.030

Cited by 31 publications

(27 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…2,4 Mortality rates are documented at 75% or greater in liver transplant recipients. 3,5 There are 2 forms of SOT-GVHD. 6 In the fi rst and more common form, group O donor antibodies form against cells in patients with disparate blood group types.…”

Section: Discussionmentioning

confidence: 99%

“…It is hypothesized that the risk factor for SOT-GVHD is related to the amount of lymphoid tissue in the donor organ. Other risk factors include greater HLA match between donor and recipient 3 and age greater than 65 years. 2,4 SOT-GVHD typically is manifested by fever, diarrhea, rash, and multilineage cytopenia or pancytopenia.…”

Section: Discussionmentioning

confidence: 99%

“…Liver transplant patients have a mortality rate of 75%. [2][3][4] Lung transplant recipients have a mortality rate of 100%. Other solid-organ transplant patients are reported to have a 30% mortality.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Solid-Organ Graft-Versus-Host Disease After Liver Transplant: A Case Report

Auerbach

Schott

2016

Critical Care Nurse

View full text Add to dashboard Cite

Solid-organ transplant graft-versus-host disease (SOT-GVHD) is a rare complication of organ transplant that is associated with high mortality. The initial signs and symptoms are vague, so this disease is easily confused with other posttransplant complications. A case of SOT-GVHD occurred after orthotopic liver transplant for liver failure due to hepatitis C in a patient in a Veterans Affairs intensive care unit. The patient had dehydration, acute kidney injuries, rashes, diarrhea, and pancytopenia. Results of skin biopsy, bone marrow biopsy, and cytogenetic studies were consistent with SOT-GVHD. Despite supportive care including antibiotics, antiviral and antifungal therapy, high-dose steroids, antithymoglobulin and neupogen, the patient died of overwhelming sepsis. Owing to the rarity of SOT-GVHD, no evidence-based guidelines or recommendations for treatment exist. Treatment includes high-dose corticosteroids and antibiotic, antifungal, and antiviral prophylaxis. Treatment of liver transplant–related GVHD with anti–tumor necrosis factor a agents has been successful.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Solid-Organ Graft-Versus-Host Disease After Liver Transplant: A Case Report

Auerbach

Schott

2016

Critical Care Nurse

View full text Add to dashboard Cite

show abstract

“…28 Other reported risk factors for SOT-GVHD are greater degrees of HLA match between donor and recipient and recipient age over 65 years. 29 Approximately 80 cases of GVHD after liver transplant were reported in 2008, with published incidence rates of 0.1% to 2%. 30 A 2008 report by Worel et al of GVHD after lung transplantation stated that fewer than 10 cases of GVHD had been reported in the denominator of over 21,000 lung transplants worldwide.…”

Section: Gvhd After Sotmentioning

confidence: 99%

Hematologic Disorders after Solid Organ Transplantation

Smith

2010

Hematology

View full text Add to dashboard Cite

The evaluation of hematologic disorders after solid organ transplantation (SOT) must take into account issues unique to the post-transplant setting that influence the development of anemia and single or multi-lineage cytopenias. Attention to the time of onset of cytopenia(s) is important, because the disorders of passenger lymphocyte syndrome, transplant-related thrombotic microangiopathy, hemophagocytic syndrome, and graft-versus-host disease typically occur during the first few months after SOT, and post-transplant lymphoproliferative disorder usually occurs within the first year. Drug-related anemia and cytopenia(s) occur due to a variety of mechanisms, including drug-induced hemolysis and marrow suppression and perturbation of T-cell subsets by the immunosuppressive agents, leading to immune dysregulation and autoimmunity. Viral infections can cause direct suppression of hematopoiesis, and a variety of opportunistic infections can precipitate acquired hemophagocytic syndrome, a frequently lethal systemic inflammatory disorder. Early investigation of pancytopenia by bone marrow biopsy is warranted, because it is often the presenting symptom of one or multiple life-threatening pathologies after SOT, such as graft-versus host disease, post-transplant lymphoproliferative disorder, hemophagocytic syndrome, or severe opportunistic infections, and these entities may have a better prognosis if early interventions are undertaken.

show abstract

“…There have only been four case reports on GVHD after kidney-only transplantation [5] . All of the cases exhibited multiple clinical symptoms.…”

Section: Introductionmentioning

confidence: 99%

Isolated intestinal manifestation of graft-versus-host disease following renal transplantation

Praktiknjo

Boes

Majores

et al. 2014

CRIM

View full text Add to dashboard Cite

Graft-versus-host disease (GVHD) is a potentially lethal complication commonly occurring after hematopoietic stem cell transplantation and non-irradiated blood cell transfusion in patients with underlying immunodeficiency. In solid organ transplantation GVHD however is a rarity. There have been four cases of GVHD after renal transplantation, most of them with fulminant systemic clinical manifestation and mostly associated with blood transfusions. We report the first case of a four HLA-antigen mismatched kidney transplant patient who presented with diarrhea due to intestine-only manifestation of GVHD and was treated successfully with quadruple immunosuppression.

show abstract

Acute Graft-Versus-Host-Disease in Kidney Transplantation: Case Report and Review of Literature

Cited by 31 publications

References 13 publications

Solid-Organ Graft-Versus-Host Disease After Liver Transplant: A Case Report

Solid-Organ Graft-Versus-Host Disease After Liver Transplant: A Case Report

Hematologic Disorders after Solid Organ Transplantation

Isolated intestinal manifestation of graft-versus-host disease following renal transplantation

Contact Info

Product

Resources

About