Acute Glomerulonephritis Associated With Normal Serum B1C-Globulin

Tina, Leticia U.

doi:10.1001/archpedi.1968.02100010031006

Cited by 8 publications

(6 citation statements)

References 13 publications

(3 reference statements)

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“…The incidence of normal C3 levels found in patients with acute glomerulonephritis has differed considerably in the various studies so far reported and a different aetiology was suggested as a possible explanation (Tina et al, 1968;West et al, 1964). Gotoff et al (1969) were the first to prove that two patients with normal C3 levels were typical cases of poststreptococcal glomerulonephritis.…”

Section: Resultsmentioning

confidence: 99%

“…been measured in a number of patients with various kidney diseases (Borgeaud, Paunier, and Humair, 1970;Gotoff et al, 1965Gotoff et al, , 1969Humair, 1968;Morse, Muiler-Eberhard, and Kunkel, 1962;Northway et al, 1969;Ogg, Cameron, and White, 1968;Tina et al, 1968;West, Northway, and Davis, 1964;West et al, 1965). Data so far reported indicate that in patients with acute glomerulonephritis C3 levels are reduced in the first few weeks of the disease (Borgeaud et al, 1970;Gotoff et al, 1965Gotoff et al, , 1969Humair, 1968;West et al, 1964).…”

mentioning

confidence: 99%

“…However, sequential determination has not been done extensively except by Humair (1968), and no studies have reported on C3 levels in the postnephritic period. The significance of normal C3 levels found in some patients with acute glomerulonephritis has not been elucidated (Gotoff et al, 1969;Tina et al, 1968;West et al, 1964) and, moreover, the problem of correlation of the clinical course of the disease with C3 concentration is still a matter of controversy (Borgeaud et al, 1970;West et al, 1964). Received 18 January 1973. The purpose of this study was to measure the initial C3 levels in a large group of patients and make sequential determinations during various phases of the disease and in the postnephritic period.…”

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confidence: 99%

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Serum C3 levels in acute glomerulonephritis and postnephritic children.

Popović-Rolović¹

1973

Archives of Disease in Childhood

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Section: Resultsmentioning

confidence: 99%

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Serum C3 levels in acute glomerulonephritis and postnephritic children.

Popović-Rolović¹

1973

Archives of Disease in Childhood

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“…PSAGN with typical renal pathologic findings on light microscopy, immunofluorescence, and electron microscopy may occur in patients with no evidence of complement activation, as manifested by depression of serum C3 concentration [122,123]. A study from Cincinnati Children's Hospital showed that 10% of children with PSAGN had normal serum C3 concentration at clinical onset [122].…”

Section: Complement Activationmentioning

confidence: 99%

Post-streptococcal acute glomerulonephritis in children: clinical features and pathogenesis

et al. 2010

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Post-streptococcal acute glomerulonephritis (PSAGN) is one of the most important and intriguing conditions in the discipline of pediatric nephrology. Although the eventual outcome is excellent in most cases, PSAGN remains an important cause of acute renal failure and hospitalization for children in both developed and underdeveloped areas. The purpose of this review is to describe both the typical and less common clinical features of PSAGN, to outline the changes in the epidemiology of PSAGN over the past 50 years, and to explore studies on the pathogenesis of the condition with an emphasis on the search for the elusive nephritogenic antigen.

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“…If the first blood sample is taken too late, the early decrease in B,, level may be missed. In addition, proven cases of A P G N have been described in whom the B,, level was normal even a t a very early stage of the disease (7,17).…”

Section: Discussionmentioning

confidence: 99%

CLINICAL VALUE OF SERUM B_1A‐ AND B_1E‐GLOBULIN LEVELS IN ADULT PATIENTS WITH RENAL DISEASE

Arisz

Brentjens

Hem

et al. 1972

Journal of Internal Medicine

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Serum levels of B1A‐globulin, a metabolic product of the third component of complement, have been investigated by a simple immunochemical method in a group of adult patients with renal disease. A renal biopsy was performed in 100 of 105 adult patients with primary renal disease and in 27 of 51 patients with secondary or other renal disease, enabling classification on histological grounds. Decreased B1A levels were found in acute poststreptococcal glomerulonephritis (APGN) and in some patients with membrano‐proliferative glomerulonephritis (MPGN) and glomerulonephritis associated with systemic lupus erythematosus (SLE). In these three categories of patients B1E‐globulin, the fourth component of complement, was also determined by the same simple immunochemical method. In APGN B1A‐globulin rises to normal levels in 1–4 months after the onset of the disease. The B1E‐globulin is occasionally decreased at a very early stage in APGN, and then returns rapidly to normal levels. In MPGN the B1A level may be constantly low for many years. Some patients, however, demonstrate a change in the level with time. The B1E level is usually normal in this group. A number of patients with MPGN had, at least on a single determination, normal B1A levels. In SLE glomerulonephritis decreased levels of both complement components are found, the B1E‐globulin usually being diminished to a greater extent than the B1A‐globulin. Occasionally only the B1E level is low, which could mean that the determination of B1E‐globulin is of greater significance for the diagnosis of SLE than the determination of B1A‐globulin. Two patients with SLE showed a parallel increase in both complement factors during longterm treatment with large doses of corticosteroids. SLE differs in this respect from APGN, and this suggests a different manner of complement activation. From this group of adult patients it may be concluded that the findings relating to serum B1A levels in children with renal disease are also applicable to adults. In addition, the determination of B1A‐ and B1A‐levels by a simple technique is of value in the differential diagnosis of patients with glomerulonephritis.

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Acute Glomerulonephritis Associated With Normal Serum B1C-Globulin

Cited by 8 publications

References 13 publications

Serum C3 levels in acute glomerulonephritis and postnephritic children.

Serum C3 levels in acute glomerulonephritis and postnephritic children.

Post-streptococcal acute glomerulonephritis in children: clinical features and pathogenesis

CLINICAL VALUE OF SERUM B_1A‐ AND B_1E‐GLOBULIN LEVELS IN ADULT PATIENTS WITH RENAL DISEASE

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Acute Glomerulonephritis Associated With Normal Serum B1C-Globulin

Cited by 8 publications

References 13 publications

Serum C3 levels in acute glomerulonephritis and postnephritic children.

Serum C3 levels in acute glomerulonephritis and postnephritic children.

Post-streptococcal acute glomerulonephritis in children: clinical features and pathogenesis

CLINICAL VALUE OF SERUM B1A‐ AND B1E‐GLOBULIN LEVELS IN ADULT PATIENTS WITH RENAL DISEASE

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CLINICAL VALUE OF SERUM B_1A‐ AND B_1E‐GLOBULIN LEVELS IN ADULT PATIENTS WITH RENAL DISEASE