Acute exercise enhances the response to paired associative stimulation-induced plasticity in the primary motor cortex

Singh, Amaya M.; Neva, Jason L.; Staines, Richard

doi:10.1007/s00221-014-4049-z

Cited by 93 publications

(96 citation statements)

References 80 publications

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“…; Singh et al. ; Lulic et al. ), there are no reports of the effects of long‐term exercise interventions on corticospinal output and intracortical circuitry.…”

Section: Discussionmentioning

confidence: 99%

“…However, Singh et al. () reported both an increase and no change in ICF following a single bout of moderate‐intensity lower‐limb exercise. Presently, it cannot be ruled out whether long‐term and acute exercise protocols have a similar influence on cortical excitation.…”

Section: Discussionmentioning

confidence: 99%

“…Further, Singh et al. () have observed increased intracortical facilitation (ICF), while Lulic et al. () found decreased ICF in the M1 representations of upper limb muscles not involved in the exercise following a single biking session.…”

Section: Introductionmentioning

confidence: 99%

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No changes in corticospinal excitability, biochemical markers, and working memory after six weeks of high‐intensity interval training in sedentary males

et al. 2019

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A single bout of aerobic exercise modulates corticospinal excitability, intracortical circuits, and serum biochemical markers such as brain‐derived neurotrophic factor ( BDNF ) and insulin‐like growth factor 1 ( IGF ‐1). These effects have important implications for the use of exercise in neurorehabilitation. Here, we aimed to determine whether increases in cardiorespiratory fitness ( CRF ) induced by 18 sessions of high‐intensity interval training ( HIIT ) over 6 weeks were accompanied by changes in corticospinal excitability, intracortical excitatory and inhibitory circuits, serum biochemical markers and working memory ( WM ) capacity in sedentary, healthy, young males. We assessed motor evoked potential ( MEP ) recruitment curves for the first dorsal interosseous ( FDI ) both at rest and during tonic contraction, intracortical facilitation ( ICF ), and short‐interval intracortical inhibition ( SICI ) using transcranial magnetic stimulation ( TMS ). We also examined serum levels of BDNF , IGF ‐1, total and precursor (pro) cathepsin B ( CTSB ), as well as WM capacity. Compared to pretraining, CRF was increased and ICF reduced after the HIIT intervention, but there were no changes in corticospinal excitability, SICI , BDNF , IGF ‐1, total and pro‐ CTSB , and WM capacity. Further, greater CRF gains were associated with larger decreases in total and pro‐ CTSB and, only in Val/Val carriers, with larger increases in SICI . Our findings confirm that HIIT is efficacious in promoting CRF and show that corticospinal excitability, biochemical markers, and WM are unchanged after 18 HIIT bouts in sedentary males. Understanding how aerobic exercise modulates M1 excitability is important in order to be able to use exercise protocols as an intervention, especially in rehabilitation following brain injuries.

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“…; Singh et al. ; Lulic et al. ), there are no reports of the effects of long‐term exercise interventions on corticospinal output and intracortical circuitry.…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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No changes in corticospinal excitability, biochemical markers, and working memory after six weeks of high‐intensity interval training in sedentary males

et al. 2019

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“…Further, our data suggests that exercise can be used to prime the motor cortex for plasticity via a reduction in inhibition, regardless of physical activity level. Recent studies have shown improvements in motor learning [88] and increased response to brain stimulation in healthy adults [24, 25, 40, 89] when exercise is used as a prime.…”

Section: Discussionmentioning

confidence: 99%

“…Aerobic exercise, therefore, provides an opportunity to create short-term changes in specific TMS circuits that may serve as targets for promoting neuroplasticity. Finally, a single session of aerobic exercise can be used to supplement other plasticity inducing approaches to yield greater effects [24–26]. …”

Section: Introductionmentioning

confidence: 99%

Physical activity levels determine exercise-induced changes in brain excitability

et al. 2017

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Emerging evidence suggests that regular physical activity can impact cortical function and facilitate plasticity. In the present study, we examined how physical activity levels influence corticospinal excitability and intracortical circuitry in motor cortex following a single session of moderate intensity aerobic exercise. We aimed to determine whether exercise-induced short-term plasticity differed between high versus low physically active individuals. Participants included twenty-eight young, healthy adults divided into two equal groups based on physical activity level determined by the International Physical Activity Questionnaire: low-to-moderate (LOW) and high (HIGH) physical activity. Transcranial magnetic stimulation was used to assess motor cortex excitability via motor evoked potential (MEP) recruitment curves for the first dorsal interosseous (FDI) muscle at rest (MEPREST) and during tonic contraction (MEPACTIVE), short-interval intracortical inhibition (SICI) and facilitation (SICF), and intracortical facilitation (ICF). All dependent measures were obtained in the resting FDI muscle, with the exception of AMT and MEPACTIVE recruitment curves that were obtained during tonic FDI contraction. Dependent measures were acquired before and following moderate intensity aerobic exercise (20 mins, ~60% of the age-predicted maximal heart rate) performed on a recumbent cycle ergometer. Results indicate that MEPREST recruitment curve amplitudes and area under the recruitment curve (AURC) were increased following exercise in the HIGH group only (p = 0.002 and p = 0.044, respectively). SICI and ICF were reduced following exercise irrespective of physical activity level (p = 0.007 and p = 0.04, respectively). MEPACTIVE recruitment curves and SICF were unaltered by exercise. These findings indicate that the propensity for exercise-induced plasticity is different in high versus low physically active individuals. Additionally, these data highlight that a single session of aerobic exercise can transiently reduce inhibition in the motor cortex regardless of physical activity level, potentially priming the system for plasticity induction.

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Effects of Exercise on Long-Term Potentiation in Neuropsychiatric Disorders

Loprinzi

2020

Physical Exercise for Human Health

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Acute exercise enhances the response to paired associative stimulation-induced plasticity in the primary motor cortex

Cited by 93 publications

References 80 publications

No changes in corticospinal excitability, biochemical markers, and working memory after six weeks of high‐intensity interval training in sedentary males

No changes in corticospinal excitability, biochemical markers, and working memory after six weeks of high‐intensity interval training in sedentary males

Physical activity levels determine exercise-induced changes in brain excitability

Effects of Exercise on Long-Term Potentiation in Neuropsychiatric Disorders

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