Effects of Exercise on Long-Term Potentiation in Neuropsychiatric Disorders

Loprinzi, Paul D.

doi:10.1007/978-981-15-1792-1_30

Cited by 4 publications

(3 citation statements)

References 227 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Aerobic exercise benefits brain growth and development and increases hippocampal volume, delays decline, reverses pathology, and prevents the development of AD by reducing oxidative stress, apoptosis, neuroinflammation, and mitochondrial dysfunction; it also promotes growth factors and improves memory [ 18 , 19 ]. Exercise improves learning and memory capacity in AD through long-term potentiation (LTP) and stimulation of the body's production of neurotrophic factors (e.g., BDNF) and nerve growth factors [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Aerobic Exercise Regulates Apoptosis through the PI3K/Akt/GSK-3β Signaling Pathway to Improve Cognitive Impairment in Alzheimer’s Disease Mice

et al. 2022

View full text Add to dashboard Cite

Neuronal apoptosis is an important factor in the etiology of Alzheimer’s disease (AD). Aerobic exercise (AE) enhances learning and memory, improves cognitive impairment, increases telomere binding protein expression, and decreases apoptosis regulators, but it remains unclear whether it can improve cognitive impairment caused by neuronal apoptosis in AD. Therefore, this study investigated whether an 8-week running table exercise intervention could reduce apoptosis and improve cognitive function in the hippocampal neurons of AD model mice. After the exercise intervention, we evaluated the learning memory ability (positioning, navigation, and spatial search) of mice using a Morris water labyrinth, Nissl staining, immunohistochemistry, and protein application to detect hippocampal PI3K/Akt/GSK-3β signaling pathway protein and hippocampal neuronal cell apoptosis protein B cell lymphoma 2 (Bcl-2) and apoptosis-promoting protein bcl-2-related X (Bax) protein expression. The results showed that aerobic exercise improved the location and spatial exploration ability of mice, increased the number of PI3K- and p-Akt-positive cells, increased the expression of PI3K, p-Akt, and bcl-2 proteins, decreased the expression of GSK-3β and Bax proteins, and increased the bcl-2/Bax ratio of mice. The results suggest that aerobic exercise can reduce apoptosis and improve cognitive function in AD mice. The molecular mechanism may involve activation of the PI3K/Akt/GSK-3β signaling pathway.

show abstract

Section: Introductionmentioning

confidence: 99%

Aerobic Exercise Regulates Apoptosis through the PI3K/Akt/GSK-3β Signaling Pathway to Improve Cognitive Impairment in Alzheimer’s Disease Mice

et al. 2022

View full text Add to dashboard Cite

show abstract

“…The data in our TMS study suggests that repetitive and regular sub-concussive impacts experienced by athletes in contact sports over multiple seasons are cumulative, and consequently contribute to maladaptive long-term potentiation (LTP) changes altering pre/post synaptic processing (10, 40). While we appreciate that the majority of LTP work stems from experimental stimulation studies (40), LTP has also been shown not only in neurological and psychiatric conditions but also with interventional methods such as exercise (41). It is plausible that our findings reflect, in this cohort, the experiences of individuals who have experienced tens of thousands of sub-concussive impacts (4) over their playing lifetime.…”

Section: Discussionmentioning

confidence: 99%

The effect of playing career on chronic neurophysiological changes in retired male football players. An exploratory study using transcranial magnetic stimulation

Pearce,

Tallent,

Frazer

et al. 2024

Preprint

View full text Add to dashboard Cite

Aim Repetitive head impact exposure, from contact and collision sports, are increasingly being attributed to increased risk of neurodegenerative disease in aging athletes. This exploratory study investigated the association of playing career in retired professional contact sport athletes with cortical neurophysiology via transcranial magnetic stimulation (TMS). Methods Male athletes between the ages of 28-68 years (n=113; mean age [SD] 48.8 [9.7]) who had been retired from professional sport for a minimum of five years were recruited. Cortical excitability was measured using single pulse TMS for motor evoked potentials and paired pulse transcranial magnetic stimulation short-interval intracortical inhibition and long-interval intracortical inhibition. Associations were assessed between transcranial magnetic stimulation measures and concussion history, clinical symptom scores, total career length (including junior to complete retirement), and professional career length (elite competition only). Results Correlations showed significant associations between motor evoked potentials and clinical symptom reporting (rho: -0.21 to -0.38; P<0.01); and motor evoked potentials and short-interval intracortical inhibition with total career length (rho: 0.26 to -0.33; P<0.01). No significant correlations were observed between single and paired-pulse transcranial magnetic stimulation and professional career length (rho: 0.16 to -0.15), nor the number of concussions (rho: 0.17 to -0.17). Conclusions This study is the first to report pathophysiological outcomes in a cohort of retired professional athletes associated with total career exposure, rather than professional career exposure or concussion history. TMS assessment could be considered a viable biomarker in future studies of retired athletes suspected with traumatic encephalopathy syndrome.

show abstract

“…Impairment in LTP and LTD have been extensively described in many types of dementia, such as AD (Skaper et al 2017 ), PD (Marinelli et al 2017 ), and HD (Filippo et al 2007 ), to name a few, with a strong correlation with the cognitive symptoms in each disease. LTP and LTD are crucial for memory formation, and impairment in these are associated with amnesic and psychiatric symptoms (Loprinzi 2020 ).…”

Section: Methodsmentioning

confidence: 99%

Central nervous system effects of 5-HT7 receptors: a potential target for neurodegenerative diseases

Quintero-Villegas

Valdés‐Ferrer

2022

Mol Med

View full text Add to dashboard Cite

Abstract5-HT7 receptors (5-HT7R) are the most recently identified among the family of serotonin receptors. Their role in health and disease, particularly as mediators of, and druggable targets for, neurodegenerative diseases, is incompletely understood. Unlike other serotonin receptors, for which abundant preclinical and clinical data evaluating their effect on neurodegenerative conditions exist, the available information on the role of the 5-HT7R receptor is limited. In this review, we describe the signaling pathways and cellular mechanisms implicated in the activation of the 5-HT7R; also, we analyze different mechanisms of neurodegeneration and the potential therapeutic implications of pharmacological interventions for 5-HT7R signaling.

show abstract

Effects of Exercise on Long-Term Potentiation in Neuropsychiatric Disorders

Cited by 4 publications

References 227 publications

Aerobic Exercise Regulates Apoptosis through the PI3K/Akt/GSK-3β Signaling Pathway to Improve Cognitive Impairment in Alzheimer’s Disease Mice

Aerobic Exercise Regulates Apoptosis through the PI3K/Akt/GSK-3β Signaling Pathway to Improve Cognitive Impairment in Alzheimer’s Disease Mice

The effect of playing career on chronic neurophysiological changes in retired male football players. An exploratory study using transcranial magnetic stimulation

Central nervous system effects of 5-HT7 receptors: a potential target for neurodegenerative diseases

Contact Info

Product

Resources

About