Acute eosinophilic pneumonia: radiologic and clinical features.

King, Mark A.; Pope-Harman, Amy; Allen, James N.; Christoforidis, Greg; Christoforidis, Anthimos J.

doi:10.1148/radiology.203.3.9169693

Cited by 110 publications

(49 citation statements)

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“…In a case series of 12 patients, none had peripherally distributed airspace consolidation. (32) These data are in contrast to those regarding AEP, in which pleural effusion is rare. Interstitial edema can be recognized by the presence of interlobular septal thickening on CT scans.…”

Section: Allergic Bronchopulmonary Aspergillosismentioning

confidence: 80%

“…In the case series of 12 patients, the airspace opacities decreased within 3 days in all patients. (32) The dose can be reduced to 40-60 mg/day and tapered over the subsequent 2-4 weeks.…”

Section: Acute Eosinophilic Pneumoniamentioning

confidence: 99%

“…Among the 22 patients included in the study conducted in France (28) and in the case series of 12 patients, (32) 14 and 7 patients, respectively, needed mechanical ventilation. All patients in the two studies recovered, and 6 of the 22 did not use corticosteroids.…”

Section: Acute Eosinophilic Pneumoniamentioning

confidence: 99%

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Eosinofilia pulmonar

Campos

Pereira

2009

J. bras. pneumol.

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Pulmonary eosinophilia comprises a heterogeneous group of diseases defined by eosinophilia in pulmonary infiltrates (bronchoalveolar lavage fluid) or in tissue (lung biopsy specimens). Although the inflammatory infiltrate is composed of macrophages, lymphocytes, neutrophils and eosinophils, eosinophilia is an important marker for the diagnosis and treatment. Clinical and radiological presentations can include simple pulmonary eosinophilia, chronic eosinophilic pneumonia, acute eosinophilic pneumonia, allergic bronchopulmonary aspergillosis and pulmonary eosinophilia associated with a systemic disease, such as in Churg-Strauss syndrome and hypereosinophilic syndrome. Asthma is frequently concomitant and can be a prerequisite, as in allergic bronchopulmonary aspergillosis and Churg-Strauss syndrome. In diseases with systemic involvement, the skin, the heart and the nervous system are the most affected organs. The radiological presentation can be typical, or at least suggestive, of one of three types of pulmonary eosinophilia: chronic eosinophilic pneumonia, acute eosinophilic pneumonia and allergic bronchopulmonary aspergillosis. The etiology of pulmonary eosinophilia can be either primary (idiopathic) or secondary, due to known causes, such as drugs, parasites, fungal infection, mycobacterial infection, irradiation and toxins. Pulmonary eosinophilia can be also associated with diffuse lung diseases, connective tissue diseases and neoplasia.Keywords: Pulmonary eosinophilia; Hypereosinophilic syndrome; Aspergillosis, allergic bronchopulmonary; Churg-Strauss syndrome. ResumoAs formas de eosinofilia pulmonar constituem um grupo heterogêneo definido pela presença de um ou dois critérios: infiltrado pulmonar com eosinofilia sanguínea e/ou eosinofilia tissular caracterizada por eosinófilos demonstrados na biópsia pulmonar ou no lavado broncoalveolar. Embora o infiltrado inflamatório seja composto de macrófagos, linfócitos, neutrófilos e eosinófilos, a presença de eosinofilia é um marcador importante para o diagnóstico e tratamento. A apresentação clínica e radiológica pode revelar eosinofilia pulmonar simples, pneumonia eosinofílica crônica, pneumonia eosinofílica aguda, aspergilose broncopulmonar alérgica e eosinofilia pulmonar associada à doença sistêmica, como na síndrome de Churg-Strauss e na síndrome hipereosinofílica. A asma está frequentemente associada, podendo ser um pré-requisito, como na aspergilose broncopulmonar alérgica e na síndrome de Churg-Strauss. Nas doenças com acometimento sistêmico, a pele, o coração e o sistema nervoso são os órgãos mais comprometidos. A apresentação radiológica pode ser considerada como típica, ou pelo menos sugestiva, para três formas de eosinofilia pulmonar: pneumonia eosinofílica crônica, aspergilose broncopulmonar alérgica e pneumonia eosinofílica aguda. A etiologia da eosinofilia pulmonar pode ser de causa primária (idiopática) ou secundária, compreendendo causas conhecidas, como drogas, parasitas, infecções por fungos e micobactérias, irradiação e toxinas. A eosinof...

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Section: Allergic Bronchopulmonary Aspergillosismentioning

confidence: 80%

“…In the case series of 12 patients, the airspace opacities decreased within 3 days in all patients. (32) The dose can be reduced to 40-60 mg/day and tapered over the subsequent 2-4 weeks.…”

Section: Acute Eosinophilic Pneumoniamentioning

confidence: 99%

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Eosinofilia pulmonar

Campos

Pereira

2009

J. bras. pneumol.

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“…Whenfour of these patients resumed smoking after the resolution of the disease, only one experienced another episode of AEP. King has reported three patients with AEPwho had begun smoking cigarettes within 2 months of onset (18). In reporting a case of AEPassociated with cigarette smoking, Nakajimaet al stressed the importance of smokingas a cause based on a positive rechallenge test (19).…”

Section: Discussionmentioning

confidence: 99%

Acute Eosinophilic Pneumonia Following Cigarette Smoking.

et al. 2000

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Twocases of acute eosinophilic pneumoniafollowing cigarette smoking are analyzed for characteristic features. The first patient noted dyspnea 14 days after initiation of smoking. The second patient noted dyspnea 12 days after beginning to smoke. Both cases had characteristic features including occurrence at an age younger than 30 years; less than 1 month duration of cigarette smoking before onset of disease ; and no identifiable cause of acute eosinophilic pneumoniaapart from smoking. Webelieve that acute eosinophilic pneumonia following cigarette smoking, which has characteristic features as described above, should be considered as a distinct subtype of AEP. (Internal Medicine 39: 830-833, 2000)

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“…Chest imaging in AEP demonstrates diffuse infiltrates/opacities, bilateral pleural effusion and interstitial edema [4]. CT Chest done for our patient showed similar findings (Figure 2) but were presumed to be due to severe/atypical CAP and thus, treated with IV antibiotics.…”

Section: Discussionmentioning

confidence: 62%