Acute eosinophilic pneumonia following heat‐not‐burn cigarette smoking

Abstract

A 20‐year‐old man was admitted with acute respiratory failure. He had started smoking 20 heat‐not‐burn cigarettes (HC) per day 6 months previously, then purchased a second device for smoking HC to increase smoking to 40 cigarettes per day 2 weeks before hospitalization. Acute eosinophilic pneumonia (AEP) was diagnosed based on medical history, chest high‐resolution computed tomographic findings, and bronchoalveolar lavage fluid eosinophilia. On starting treatment with prednisolone, the patient exhibited complete recovery. A relationship between cigarette smoking and AEP has been suggested. HC were released in September 2015 in Japan, Italy, and Switzerland. HC attract attention as a cigarette generating less harmful substances than a conventional cigarette. We herein report the first case of AEP caused by smoking HC. HC are expected to spread around the world. In the same way as a conventional cigarette, HC should be recognized as a potential cause of AEP.

New ideas, old problems? Heated tobacco products – a systematic review

“…Researchers from Japan reported 2 cases of acute eosinophilic pneumonia following HTP use [81,82]. The first case of acute eosinophilic pneumonia was diagnosed in a 20-yearold man who had smoked 20 IQOS sticks daily for 6 months and doubled stick consumption 2 weeks before the hospitalization [81].…”

“…Researchers from Japan reported 2 cases of acute eosinophilic pneumonia following HTP use [81,82]. The first case of acute eosinophilic pneumonia was diagnosed in a 20-yearold man who had smoked 20 IQOS sticks daily for 6 months and doubled stick consumption 2 weeks before the hospitalization [81]. The second case of fulminant acute eosinophilic pneumonia was diagnosed in 16-year-old man with bronchial asthma in childhood, who had used HTPs for 2 weeks [82].…”

Heat Not Burn Tobacco Product—A New Global Trend: Impact of Heat-Not-Burn Tobacco Products on Public Health, a Systematic Review

“…However, the health risks correlated to HnB tobacco products have not yet been clarified. It is important to note that according to the available literature, tobacco smoking is one of the main causes of AEP, however, it occurs secondary to drug exposure or hypersensitivity reactions to an inhaled antigen [2]. In this systematic review, we aimed to assess the impact of heat-not-burn tobacco products on public health.…”

Productos de tabaco calentado (Heat-not-burn tobacco products): concepciones e implicaciones para la Salud Pública

“…Es evidente un fuerte debate en la literatura encontrada sobre las nociones de "calentamiento" vs "combustión" 19,20 , así como sobre las concentraciones de esas mismas sustancias cuya presencia se busca reducir o eliminar en los HTP. Como sucede con cualquier sustancia química, compuesto farmacológico o producto tecnológico para el consumo, pueden aparecer y ser reportadas reacciones adversas a raíz de su uso 21 , las cuales son evidentes únicamente en el mercado y en el mundo real, más allá de la investigación de laboratorio y de la cada vez mayor posibilidad de realizar modelos de simulación con elementos de computación e inteligencia artificial. También hay un reclamo válido respecto que la mayor parte de la investigación de laboratorio relacionada con estos productos procede de las diferentes compañías de la industria tabacalera, en las que la mayor parte de la investigación independiente procede la academia en países desarrollados y está enfocada hacia la conciencia de producto o hacia las preferencias de consumo/precio de estos productos.…”