Acute encephalopathy with biphasic seizures and late reduced diffusion

Yadav, Saroj S; Lawande, Malini; Kulkarni, Shilpa; Patkar, Deepak

doi:10.4103/1817-1745.111429

Cited by 12 publications

(6 citation statements)

References 7 publications

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“…There are two stages in the acute phase of AESD. [ 1 , 2 ] The first stage is characterized by a prolonged febrile seizure, which usually lasts for >30 min. Consciousness is generally improved on the second day after the episode.…”

Section: Discussionmentioning

confidence: 99%

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Acute encephalopathy with biphasic seizures and late reduced diffusion

Ma¹,

Xu²,

Chen³

et al. 2020

Medicine

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Rationale: Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) has been reported almost exclusively in the Japanese population. Patient concerns: A 17-month-old male patient presented with fever and seizures, and subsequently fell into a coma. On the second day, he recovered consciousness. On the fourth day, he developed complex partial seizures and fell into a coma again. On day 10, the fever and seizures subsided. Head computed tomography on the first day showed no abnormalities. Brain diffusion-weighted images on the fourth day revealed reduced diffusion in the bilateral subcortical white matter. Diagnosis: A diagnosis of AESD was made. Interventions: The patient was treated with corticosteroids and intravenous immunoglobulin. Outcomes: At the 4-month follow-up, the patient was able to walk independently, and the epileptic seizures were well controlled. Lessons: AESD is a rare entity, and treatment with corticosteroids and intravenous immunoglobulin can lead to a favorable prognosis. Clinicians should be aware of this condition, and clinicoradiological features can suggest the diagnosis.

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Section: Discussionmentioning

confidence: 99%

“…Acute encephalopathy with biphasic seizures and late reduced diffusion (AESD) is the most common subtype of acute encephalopathy, and accounts for ∼30% of all cases. [ 1 ]…”

Section: Introductionmentioning

confidence: 99%

Acute encephalopathy with biphasic seizures and late reduced diffusion

Ma¹,

Xu²,

Chen³

et al. 2020

Medicine

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“…Acute encephalopathy with biphasic seizures and late reduced diffusion is rarely reported outside of Japan; only 3 children, one each in Turkey, India, and United States, have been reported thus far. 7,9,10 Furthermore, the American patient was a Japanese infant residing there, indicating a possible underlying genetic background related to the development of acute encephalopathy with biphasic seizures and late reduced diffusion. 3,7 However, many cases with acute encephalopathy with biphasic seizures and late reduced diffusion might be missed because MRI abnormality is not seen for a few days.…”

Section: Discussionmentioning

confidence: 99%

Acute Encephalopathy With Biphasic Seizures and Late Reduced Diffusion Associated With Adenoviral Pneumonia

Lee

Heo

2019

Child Neurology Open

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Acute encephalopathy with biphasic seizures and late reduced diffusion is a subtype of acute encephalopathy described in a cohort of Japanese children. Few cases have been reported in countries other than Japan. It is characterized clinically by biphasic seizures and late reduced subcortical diffusion on magnetic resonance imaging (MRI). We report the case of a 3-year-old Korean girl with acute encephalopathy with biphasic seizures and late reduced diffusion who presented with status epilepticus associated with fever and pneumonia. Human adenovirus was detected from a respiratory specimen using multiplex real-time reverse transcriptase polymerase chain reaction. After 5 days, she developed a second cluster of seizures followed by altered consciousness, aphasia, stereotypic movement, and developmental regression. Her brain MRI showed symmetrical and extensive restricted diffusion in the subcortical white matter, which finally resulted in global brain atrophy, consistent with acute encephalopathy with biphasic seizures and late reduced diffusion. Here, we report a case of acute encephalopathy with biphasic seizures and late reduced diffusion associated with preceding adenoviral pneumonia.

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“…Most of the reported cases in the literature are from Japan. Reports of patients other than of East Asian descent are uncommon . This may be due to genetic and immune‐mediated factors influencing increased expression in Asian countries.…”

Section: Discussionmentioning

confidence: 99%