Acute effects of waterpipe smoking on blood pressure and heart rate: a real-life trial

Azar, Rabih R.; Frangieh, Antonio H.; Mroue, Jad; Bassila, L.; Kasty, Mohamad T.; Hage, Georges; Kadri, Zena

doi:10.3109/08958378.2016.1171934

Cited by 26 publications

(18 citation statements)

References 18 publications

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“…Several studies revealed that waterpipe smoking increased the blood pressure, heart rate and eventually the risk of overall cardiovascular events [36,37]. The current study showed increased systolic blood pressure in animals that were exposed to chronic WTS, consistent with Nemmar and colleagues finding [38].…”

Section: Plos Onesupporting

confidence: 90%

Effect of waterpipe tobacco smoke exposure on the development of metabolic syndrome in adult male rats

et al. 2020

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The prevalence of metabolic syndrome is increased worldwide. Tobacco smoking increases the risk of developing metabolic syndrome. Waterpipe tobacco smoking has become a global trend of tobacco consumption and is as common as cigarette smoking. In this study, the effect of waterpipe tobacco smoke (WTS) on the development of metabolic syndrome in rats was evaluated. Adult Wistar rats were exposed for 19 weeks to either fresh air (control) or WTS for 1 hour daily/ 5 days per week (WTS). Central obesity, systolic blood pressure, lipid profile, glucose hemostasis and levels of leptin and adiponectin were evaluated. The WTS exposure increased body weight, abdominal circumference, systolic blood pressure and fasting glucose compared to control animals (P<0.05), consistent with inducing metabolic syndrome. The retroperitoneal fat, lipid profile and levels of insulin, leptin and adiponectin were not affected by WTS exposure (P>0.05). In conclusion, exposure to WTS has detrimental health effects leading to the development of metabolic syndrome in experimental animals.

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Section: Plos Onesupporting

confidence: 90%

Effect of waterpipe tobacco smoke exposure on the development of metabolic syndrome in adult male rats

et al. 2020

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“…Acute exposure to water pipe smoking is associated with a significant increase in SBP and heart rate compared with nonsmoking control subjects, 30 but long-term effects remain unclear. Current use of smokeless tobacco is associated with an increased risk of CVD events in cigarette nonsmokers.…”

Section: Smoking/tobacco Usementioning

confidence: 99%

Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association

Benjamin¹,

Blaha²,

Chiuve³

et al. 2017

Circulation

7,578

5,040

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“…Several clinical studies have reported that WPS induces an increase in systolic blood pressure. This effect has been related to the sympathomimetic effect of nicotine [22,23].…”

Section: Discussionmentioning

confidence: 99%

Waterpipe Tobacco Smoke Inhalation Triggers Thrombogenicity, Cardiac Inflammation and Oxidative Stress in Mice: Effects of Flavouring

Al-Salam

Beegam

Yuvaraju

et al. 2020

IJMS

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The consumption of water-pipe smoking (WPS) has been promoted by the use of flavoured tobacco. However, little is known about the impact of flavouring on the cardiovascular toxicity induced by WPS inhalation. Here, we compared the cardiovascular effects and underlying mechanism of actions of plain (P) (unflavoured) versus apple-flavoured (AF) WPS (30 minutes/day, 5 days/week for 1 month) in mice. Control mice were exposed to air. Both P- and AF-WPS inhalation induced an increase in systolic blood pressure, thrombogenicity and plasma concentration of fibrinogen and von Willebrand factor. In heart homogenates, AF-WPS inhalation caused an increase of 8-isoprostane and a decrease in the levels of reduced glutathione (GSH) and superoxide dismutase (SOD). Nevertheless, P-WPS decreased only the activity of SOD. The concentrations of tumour necrosis factor α and interleukin 1β were increased only in heart homogenates of mice exposed to AF-WPS. Although both P- and AF-WPS increased the concentration of troponin I in heart homogenates and induced DNA damage, the concentration of cleaved caspase 3 was only increased in mice exposed to AF-WPS. Immunohistochemical analysis of the hearts showed that both P- and AF- WPS inhalation decreased the expression of SOD. Moreover, the expression of nuclear factor erythroid-derived 2-like 2 at nuclear level in the heart was higher in both AF-WPS and P-WPS compared with control group, and the effect observed in AF-WPS group was more significant than that seen in P-WPS group. Likewise, the concentration of heme oxygenase-1 was significantly increased in both P-WPS and AF-WPS groups compared with control group, and the effect seen in AF-group was higher than that observed in P-WPS group. In conclusion, our findings showed that both P- and AF-WPS induce thrombogenicity and cardiac injury, and that this toxicity is potentiated by the presence of flavouring.

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Acute effects of waterpipe smoking on blood pressure and heart rate: a real-life trial

Abstract: Waterpipe smoking for duration as short as 15 min has acute hemodynamic effects and significantly increases systolic BP and HR.

Cited by 26 publications

References 18 publications

Effect of waterpipe tobacco smoke exposure on the development of metabolic syndrome in adult male rats

Effect of waterpipe tobacco smoke exposure on the development of metabolic syndrome in adult male rats

Heart Disease and Stroke Statistics—2017 Update: A Report From the American Heart Association

Waterpipe Tobacco Smoke Inhalation Triggers Thrombogenicity, Cardiac Inflammation and Oxidative Stress in Mice: Effects of Flavouring

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