Acute effects of vinegar intake on some biochemical risk factors of atherosclerosis in hypercholesterolemic rabbits

Abstract

BackgroundExaggerated postprandial spikes in blood glucose and lipids induce proportional increases in oxidative stress, which acutely trigger impairment endothelial, inflammation and increased risk of future cardiovascular events. In this research, we have investigated acute effects of vinegar intake on some of the biochemical atherosclerosis risk factors in high cholesterol fed rabbits to see if we can find a probable protective value for it.MethodsThe rabbits were randomly divided into four groups: normal diet, high cholesterol diet (%1cholesterol), %1 cholesterol with 5 ml vinegar (low dose), %1 cholesterol with 10 ml vinegar (high dose). After fasting for 12-15 hours, blood samples were taken to determine baseline values. Three hours after feeding, blood samples were collected again to investigate acute effects of vinegar intake on the measured factors.ResultsUsing high-dose vinegar with cholesterolemic diet caused significant reduce in LDL-cholesterol (LDL-C), oxidized-LDL (ox-LDL), malondialdehyde (MDA), total cholesterol (TC) and apolipoprotein B (ApoB) in comparison with hypercholesterolemic diet. Consumption low-dose vinegar with cholesterolemic diet induced a significant decrease in fibrinogen and glucose compared to hypercholesterolemic diet. Level of serum nitrite, nitrate, triacylglycerol (TAG), HDL-cholesterol (HDL-C), apolipoprotein A (ApoA), serum glutamic pyruvic transaminase (SGPT), serum glutamic oxaloacetate transaminase (SGOT) and C-reactive protein (CRP) were not significantly difference in low and high doses vinegar with cholesterolemic diet compared to hypercholesterolemic diet. A significant difference was observed for LDL-C, ApoB100 and TC between low and high doses vinegar.ConclusionThis study suggest that vinegar, might have some acute effects on biochemical risk factors of atherosclerosis and a probable protective value can be considered for its postprandial use.

Prospective randomized clinical trial evaluating the impact of vinegar on lipids in non-diabetics

“…Dr. James Lind in 1746 compared vinegar, dilute sulfuric acid, cider, sea water, a physician's remedy of nutmeg, garlic and horseradish mixture versus a diet of oranges and lemons to prevent scurvy [28]. Recent data in animals suggest vinegar improves lipids, and our small non randomized trial implied improvement in HDL-C [21][22][23]. Unfortunately, our larger randomized trial results did not indicate that apple cider vinegar impacted HDL-C compared to control.…”

“…The dietary intake of vinegar has been reported to lower triglyceride levels [21], reduce LDL-C, and raise HDL-C in several animal studies [22,23]. We performed a small nonrandomized pilot study with one, two, three or six teaspoons of apple cider vinegar and found an increase in HDL-C trended with increase in dose.…”

The study of morphological traits of dill and quality of it essential fruit oil

“…Kao novi svetski trend nameće se prevencija ovih obolenja uvođenjem u ishranu prirodnih antioksidanasa. Mirođija je zbog svoje aromatičnosti jedan od omiljenih suplemenata, a dokazano je i da deluje preventivno na navedene bolesti (Yazdanparast andBahramikia 2008, Sahib et al 2012, Thukham-Mee and Wattanathorn 2012, Setorki et al 2013, Mishra 2013). Etarsko ulje plodova mirođije može da se koristi za kontrolu skladišnih insekata, bubašvaba i muva (Babri et al 2012, Khani and.…”

Pre-Clinical Evaluation of Lowering Atherosclerosis Risk Factors in Hypercholesterolemic Rats and the Immunomodulating Action of Ganoderma Lucidum and Chrysanthemum Indicum Linn

“…The method used is a modification of Setorki et al (2010). Baseline blood samples were drawn from the tail of the rats before they were given treatments.…”