Acute Effects of Ovarian Steroids upon Follicular Growth in the Cycling Rat

Hori, Takashi; Kato, Go; Miyake, Tamotsu

doi:10.1507/endocrj1954.20.475

Cited by 7 publications

(1 citation statement)

References 6 publications

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“…This may be attributed to the progestational activity of the com pound, as it has been reported that administration of high doses of progesterone on day 2 of diestrus delayed ovulation (5,7,17,22) and inhibited follicular growth (11,17). Beattie and Corbin (3) found large atretic, sometimes cystic, and few small follicles after administration of high antiovulatory doses of proges terone or J-norgestrel to rats on day 2 of diestrus.…”

Section: Discussionmentioning

confidence: 95%

Evidence for a Role of Androgens in the Growth and Maturation of Ovarian Follicles in Rats

Kumari¹,

Datta²,

Das³

et al. 1978

Horm Res

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Changes in the morphology and steroid content of ovaries were studied after 48 h of intravenous injection of 100 µg of cyproterone acetate or flutamide to diestrus or estrous rats. Treatment with cyproterone acetate at diestrus caused a decrease in the number of small follicles ( < 200 µm), freshly formed corpora lutea and the levels of estradiol-17β in the ovary, suggesting inhibition of ovulation. Following flutamide administration at diestrus, the number of follicles at all stages of development were reduced with a concomitant decrease in the ovarian levels of the hormones. Thus, flutamide suppressed the growth and maturation of follicles. On administration of these drugs at estrous, the steroid content of ovaries was more pari passu with the increase in the number of mature and medium follicles. The differential effects of the two drugs are discussed in the light of these observations.

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Section: Discussionmentioning

confidence: 95%

Evidence for a Role of Androgens in the Growth and Maturation of Ovarian Follicles in Rats

Kumari¹,

Datta²,

Das³

et al. 1978

Horm Res

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Intra-Ovarian Actions of Steroids in Regulation of Follicular Steroid Biosynthesis

Armstrong

Daniel

Gore-Langton

1987

Endocrinology and Physiology of Reproduction

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Inhibitory effect of progesterone on follicular growth and induced superovulation in the rat

1980

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We investigated the effect of exogenous progesterone on follicular growth and pregnant mares' serum gonadotropin and human chorionic gonadotropin (PMS-HCG) induced superovulation in intact and hypophysectomized immature rats. Although the administration of progesterone during PMS-HCG injections had no effect on superovulation, the administration of progesterone beginning 3 days before PMS injection inhibited superovulation in both intact and hypophysectomized rats. In order to study the mechanism of inhibition of superovulation by pretreatment with progesterone, an autoradiographic study using tritiated thymidine was done in hypophysectomized rats just before PMS injection. The labelling indices of granulosa cells were significantly decreased by the administration of progesterone (p < 0.001). Treatment with progesterone resulted in an increase of the follicles in early stages of atresia with pycnotic nuclei in granulosa cells surrounding apparently normal oocytes. Ovarian histology and serum and ovarian tissue concentrations of estradiol were then examined in hypophysectomized rats 20 h after HCG injection. Large Graafian follicles and corpora lutea were rarely seen in rats previously given progesterone, whereas many large Graafian follicles and corpora lutea were observed in the control rats. The concentrations of estradiol in the progesterone-pretreated rats were significantly reduced in serum (p < 0.02) and slightly reduced in ovarian tissues when compared with controls.

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Acute Effects of Ovarian Steroids upon Follicular Growth in the Cycling Rat

Cited by 7 publications

References 6 publications

Evidence for a Role of Androgens in the Growth and Maturation of Ovarian Follicles in Rats

Evidence for a Role of Androgens in the Growth and Maturation of Ovarian Follicles in Rats

Intra-Ovarian Actions of Steroids in Regulation of Follicular Steroid Biosynthesis

Inhibitory effect of progesterone on follicular growth and induced superovulation in the rat

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