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Crosstalk between inflammatory signalling pathways and receptor tyrosine kinases has been revealed as an indicator of cancer malignant progression. In the present study, we focus on EphA2 receptor tyrosine kinase, which is overexpressed in many human cancers. It has been reported that ligand-independent phosphorylation of EphA2 at Ser-897 is induced by Akt. We show that inflammatory cytokines promote RSK-, not Akt-, dependent phosphorylation of EphA2 at Ser-897. In addition, the RSK–EphA2 signalling pathway controls cell migration and invasion of metastatic breast cancer cells. Moreover, Ser-897-phosphorylated EphA2 co-localizes with phosphorylated active form of RSK in various human tumour specimens, and this double positivity is related to poor survival in lung cancer patients, especially those with a smoking history. Taken together, these results indicate that the phosphorylation of EphA2 at Ser-897 is controlled by RSK and the RSK–EphA2 axis might contribute to cell motility and promote tumour malignant progression.

Library of Congress Cataloging-in-Publication Data. Hori, Takashi, 1956-Gate dielectrics and MOS ULSls: principles, techoologies, and applications / Takashi Hori. p. em. -(Springer series in electronics and photonics; v. 34) Includes bibliographical references and index. ISBN 3-540-63182-8 (alk. paper) I. Integratd circuits-Ultra large scale integration. 2. Dielectric devices. 3. Metal oxide semiconductors. 4. Silicon-on-insulator technology. I.

5Gas separation properties of CH 4 /CO 2 and CH 4 /C 2 H 6 for flexible 2D porous coordination polymers under equilibrium gas condition and mixture gas flowing condition were investigated and the gas separation efficiencies were optimized by precise tuning of flexibility in ligand-base solid solution compounds. Notes and references70

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