Acute effects of methyl parathion and diazinon as inducers for oxidative stress on certain biomarkers in various tissues of rainbowtrout (Oncorhynchus mykiss)

Isık, Ismail; Çelik, İsmail

doi:10.1016/j.pestbp.2008.06.001

Cited by 80 publications

(28 citation statements)

References 26 publications

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“…Elevated GST activity may reflect the possibility of better protection against pesticide toxicity [1,11]. The increased GST activity following exposure to DZN in various tissues of fish has been reported previously [11,13,22]. In addition, GST activity was not significantly affected after exposure to some OPs [21,26].…”

Section: Discussionmentioning

confidence: 55%

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Strain-Related Differences on Response of Liver and Kidney Antioxidant Defense System in Two Rat Strains Following Diazinon Exposure

Salehi

Jafari

Asgari

et al. 2016

Zahedan J Res Med Sci

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Background: Diazinon (DZN) is one of the most organophosphates that widely used in agriculture and ectoparasiticide formulations. Its extensive use as an effective pesticide was associated with the environmental deleterious effects on biological systems. Objectives: The aim of this study was to investigate the potency of DZN to affect serum biochemical parameters and the antioxidant defense system in the liver and kidney of two rat strains. Materials and Methods:In this experimental study, 30 female Wistar and 30 female Norway rats were randomly divided into control and DZN groups. DZN group was divided into four subgroups: 25, 50, 100 and 200 mg/kg of DZN administered groups by i.p. injection. The parameters were evaluated after 24 hours. Results: At higher doses of DZN, superoxide dismutase, catalase, glutathione S-transferase and lactate dehydrogenase activities and glutathione (GSH) and malondialdehyde levels in liver and kidney of Wistar rats were higher than Norway rats. At these concentrations, DZN increased some serum biochemical indices such as liver enzymes activities and levels of urea, uric acid and creatinine in Wistar rat. Conclusions: DZN at higher doses alters the oxidant-antioxidant balance in liver and kidney of both rat strains and induces oxidative stress, which is associated with a depletion of GSH and increased lipid peroxidation. However, Wistar rats are found to be more sensitive to the toxicity of DZN compared to Norway rats. In addition, the effect of DZN on liver antioxidant system was more than kidney.

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Section: Discussionmentioning

confidence: 55%

“…Six rats in each group were anesthetized with diethyl ether 24 hours [12,13] after DZN administration. Blood samples were taken by cardiac puncture and allowed to stand for 30 minutes at room temperature to clot before being centrifuged at 3,000 × g for 15 minutes.…”

Section: Serum and Tissue Preparationmentioning

confidence: 99%

Strain-Related Differences on Response of Liver and Kidney Antioxidant Defense System in Two Rat Strains Following Diazinon Exposure

Salehi

Jafari

Asgari

et al. 2016

Zahedan J Res Med Sci

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“…Increased volume of superoxide anion radicals (O 2.-) after the metabolism of diazinon might have been responsible for this finding. A previous study justified decreased SOD levels in rainbow trout 24, 48 and 72 hours after exposure to 0.5-1.0 ppm diazinon by the depletion of the enzyme following the removal of superoxide anion radicals [52] (Figure 1). …”

Section: Evaluation Of Sod Activitymentioning

confidence: 60%

Effects of Vitamin E, Selenium and Vitamin C on Various Biomarkers Following Oxidative Stress Caused by Diazinon Exposure in Rainbow Trout

Mirvaghefi¹,

Ali²,

Asadi³

2015

JAMB

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“…Many environmental pollutants have been reported to disrupt the prooxidant/antioxidant balance in cells, and, consequently, lead to oxidative stress [18]. Reactive oxygen metabolites such as superoxide anion, hydroxyl radical, peroxyl radical, and hydrogen peroxide are cytotoxic agents that cause oxidative damage by attacking membrane lipids, proteins, and nucleic acids in cells.…”

Section: Introductionmentioning

confidence: 99%

Antioxidant defense system parameters in isolated fish hepatocytes exposed to bisphenol A — Effect of vitamin C

Kaya¹,

Kaptaner²

2016

Acta Biologica Hungarica

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In this study, isolated hepatocytes of pearl mullet (Alburnus tarichi) were exposed to bisphenol A (BPA) at concentrations of 25, 50, 100, and 200 µM for 24 h. Moreover, an in vitro antioxidant concentration of vitamin C (50 µM) was administrated to the culture medium along with the BPA exposures. Next, the antioxidant defense system parameters were analyzed. According to the results, the highest concentration of BPA (200 µM) proved to be severely toxic for the cells. The increased activities of superoxide dismutase (SOD) and glutathione-S-transferase (GST), the fluctuated activities of glutathione peroxidase (GPx), and the decreased content of reduced glutathione (GSH) were compared to the control group after the BPA exposures. Vitamin C co-administration was found to cause further increases in the SOD, GPx, and GST activities in some of the experimental groups and vitamin C could not restore the GSH content. Malondialdehyde (MDA) levels were observed to be unaffected in all exposure groups. These results show that BPA causes alterations in the antioxidant defenses of the isolated fish hepatocytes. In addition, vitamin C co-administration along with BPA was found to be non-protective against BPA-induced oxidative stress, consequently, aggravated a negative BPA impact.

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Acute effects of methyl parathion and diazinon as inducers for oxidative stress on certain biomarkers in various tissues of rainbowtrout (Oncorhynchus mykiss)

Cited by 80 publications

References 26 publications

Strain-Related Differences on Response of Liver and Kidney Antioxidant Defense System in Two Rat Strains Following Diazinon Exposure

Strain-Related Differences on Response of Liver and Kidney Antioxidant Defense System in Two Rat Strains Following Diazinon Exposure

Effects of Vitamin E, Selenium and Vitamin C on Various Biomarkers Following Oxidative Stress Caused by Diazinon Exposure in Rainbow Trout

Antioxidant defense system parameters in isolated fish hepatocytes exposed to bisphenol A — Effect of vitamin C

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