Acute effects of Fraxinus excelsior L. seed extract on postprandial glycemia and insulin secretion on healthy volunteers

Visen, P. K. S.; Saraswat, Binduja; Visen, Aastha; Roller, Marc; Bily, Antoine; Mermet, C.; He, Kan; Bai, Naisheng; Lemaire, Benoı̂t; Lafay, Sophie; Ibarra, Alvin

doi:10.1016/j.jep.2009.08.039

Cited by 33 publications

(26 citation statements)

References 35 publications

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“…In positive ESI mode, the spectra of nuzhenide showed a signal at m=z 709.2 [MþNa] þ , while a signal at m=z 1095.4 [MþNa] þ was observed for GI-3. The data were in agreement with previously published papers regarding the identification and purity of the peaks involved (Visen et al 2009). The quantitative analysis results show that the seeds generally contain the two major constituents (nuzhenide and GI-3), and the content ranges [mg (g of dw) À1 ] are 3.0-6.0 (nuzhenide) and 10.0-14.0 (GI-3).…”

Section: Quantification Of Nuzhenide and Gi-3 In O Fragrans' Seedssupporting

confidence: 92%

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Isolation and Determination of Iridoid Glycosides from the Seeds ofOsmanthus fragransby HPLC

et al. 2013

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Osmanthus fragrans is a traditional economic and ornamental plant in China. Iridoid glycosides are one of the main active ingredients of this plant. The ethanol extract of O. fragrans' seeds was analyzed by an HPLC method. The HPLC profile allowed the isolation of nuzhenide and GI-3 from O. fragrans' seeds for the first time. A C18 column was used with a mixture of methanol and water as the mobile phase using a gradient elution technique. Nuzhenide and GI-3 as the major components were used successfully as chemical markers to determine the optimal time of O. fragrans' seeds for collection. Experimental results show nuzhenide and GI-3 reached the highest level in the last ten days of April, with contents of 6.04 mg (g of dw) À1 and 13.24 mg (g of dw) À1 , higher than that of olive seeds. The study showed that O. fragrans' seeds can serve as a source of iridoid glycosides.

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Section: Quantification Of Nuzhenide and Gi-3 In O Fragrans' Seedssupporting

confidence: 92%

“…In additional, nuzhenide may be the highest antioxidant activity compound in the olive seed extracts (Silva et al 2006). So, nuzhenide and GI-3 can also be used as reference compounds to control the quality of Fraxinus excelsior (family: Oleaceae) (Visen et al 2009). …”

Section: Chemical Structuresmentioning

confidence: 99%

Isolation and Determination of Iridoid Glycosides from the Seeds ofOsmanthus fragransby HPLC

et al. 2013

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“…The parts of the plants have been reported to be effective in the treatment of various diseases. The barks of Fraxinus excelsior have long been used as antibacterial (Middleton et al 2005), seed extract has been used as a potent hypoglycemic agent (Visen et al 2009). The alcoholic extract of bark has been reported to possess an anti-inflammatory property (Ghazaly et al 1992).…”

Section: Introductionmentioning

confidence: 99%

Microwave-assisted green synthesis of silver nanoparticles from Fraxinus excelsior leaf extract and its antioxidant assay

et al. 2015

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The biosynthesis of nanoparticles has been proposed as a cost effective and environmentally benevolent alternative to chemical and physical methods. In the present study, microwave assisted synthesis of silver nanoparticles (AgNPs) has been demonstrated using leaf extract of Fraxinus excelsior reducing aqueous AgNO 3 solution. The synthesized nanoparticles have been characterized on the basis of fourier transform infrared spectroscopy (FT-IR), UV-Vis spectroscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM) and energy dispersive X-ray (EDX) analysis. The presence of a characteristic surface plasmon resonance (SPR) absorption band at 425 nm in UV-Vis reveals the reduction of silver metal ions into silver nanoparticles. FT-IR analysis was carried out to probe the possible functional group involved in the synthesis of AgNPs. Further leaf extracts and AgNPs were evaluated for antiradical scavenging activity by 1,1-diphenyl-2-picryl-hydrazyl (DPPH) assay.

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“…Few human studies have explored vegetables as a potential source of phytochemicals which could effect PPG. A Flaxinius species extract was found to have an acute effect postprandial glucose levels in healthy male volunteers (Visen et al, 2009). Another particularly phytochemical rich plant source found to effect PPG in healthy volunteers was seaweed (Goni et al, 2000).…”

Section: Impact Of Phytochemicals On Blood Glucose Regulationmentioning

confidence: 99%

Impact of Diet Composition on Blood Glucose Regulation

Russell

Baka

Björck

et al. 2013

Critical Reviews in Food Science and Nutrition

179

121

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Nutritional management of blood glucose levels is a strategic target in the prevention and management of type 2 diabetes mellitus (T2DM). To implement such an approach, it is essential to understand the effect of food on glycemic regulation and on the underlying metabolic derangements. This comprehensive review summarizes the results from human dietary interventions exploring the impact of dietary components on blood glucose levels. Included are the major macronutrients; carbohydrate, protein and fat, micronutrient vitamins and minerals, nonnutrient phytochemicals and additional foods including low-calorie sweeteners, vinegar, and alcohol. Based on the evidence presented in this review, it is clear that dietary components have significant and clinically relevant effects on blood glucose modulation. An integrated approach that includes reducing excess body weight, increased physical activity along with a dietary regime to regulate blood glucose levels will not only be advantages in T2DM management, but will benefit the health of the population and limit the increasing worldwide incidence of T2DM.

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Acute effects of Fraxinus excelsior L. seed extract on postprandial glycemia and insulin secretion on healthy volunteers

Cited by 33 publications

References 35 publications

Isolation and Determination of Iridoid Glycosides from the Seeds ofOsmanthus fragransby HPLC

Isolation and Determination of Iridoid Glycosides from the Seeds ofOsmanthus fragransby HPLC

Microwave-assisted green synthesis of silver nanoparticles from Fraxinus excelsior leaf extract and its antioxidant assay

Impact of Diet Composition on Blood Glucose Regulation

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